Autoimmune diabetes: How many steps for one disease?

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

1994 • 640 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

1997 • 414 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

Mouse NK1+ T cells

1995 • 292 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

Prevention of diabetes in NOD mice treated with antibody to murine IFNγ

1991 • 263 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 • 219 citations

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

1996 • 207 citations

Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice

1988 • 199 citations

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

1995 • 160 citations

Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus

1989 • 122 citations

Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning

1989 • 122 citations

Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes.

1989 • 106 citations

Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses.

1996 • 103 citations

High Incidence of Thyroiditis and Anti-Thyroid Autoantibodies in NOD Mice

1992 • 101 citations

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse.

1988 • 94 citations

Anti‐α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1991 • 89 citations

Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.

1990 • 76 citations

Characterization of Antinuclear Autoantibodies Present in the Serum from Nonobese Diabetic (NOD) Mice

1993 • 61 citations

Diabetes Results from a Late Change in the Autoimmune Response of NOD Mice

1997 • 61 citations

Hemolytic anemia in non‐obese diabetic mice

1991 • 60 citations

Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice

1996 • 58 citations

Evidence of CD4 + regulatory T cells in the non-obese diabetic male mouse

1994 • 55 citations

Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes mellitus

1989 • 52 citations

Islet‐infiltrating T cell clones from non‐obese diabetic mice that promote or prevent accelerated onset diabetes

1991 • 49 citations

Prevention of autoimmune type I diabetes by CD4+ suppressor T cells in superantigen-treated non-obese diabetic mice.

1993 • 39 citations

High incidence of thyroiditis and anti-thyroid autoantibodies in NOD mice

1992 • 29 citations

Protection of nonobese diabetic mice from autoimmune diabetes by reduction of islet mass before insulitis.

1996 • 26 citations

Neonatal induction of allogeneic tolerance prevents T cell‐mediated autoimmunity in NOD mice

1989 • 26 citations

Course of pancreatic beta cell destruction in prediabetic NOD mice: a histomorphometric evaluation.

1994 • 19 citations

Dissociated effects of thymectomy at weaning on T-cell-mediated responses in vitro: Correction by the serum thymic factor, FTS, and its analogs

1981 • 9 citations

Deleted Work

1955 • 0 citations