Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor–reactive cytotoxic T lymphocytes

Dendritic cells and the control of immunity

1998 • 14,345 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Adoptive-cell-transfer therapy for the treatment of patients with cancer

2003 • 656 citations

Characteristics of a Human Diploid Cell Designated MRC-5

1970 • 593 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia

2000 • 345 citations

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

2004 • 320 citations

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

1998 • 247 citations

Costimulation of CD8 T Cell Responses by OX40

2004 • 176 citations

New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population

2003 • 168 citations

CD40-Activated B-Cell Chronic Lymphocytic Leukemia Cells for Tumor Immunotherapy: Stimulation of Allogeneic Versus Autologous T Cells Generates Different Types of Effector Cells

1999 • 156 citations

Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand‐dependent pathway

1996 • 149 citations

Human CD40‐ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

1993 • 143 citations

CD40 Ligand Induces an Antileukemia Immune Response In Vivo

1997 • 142 citations

Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

1997 • 131 citations

Efficient infection of primitive hematopoietic stem cells by modified adenovirus

2001 • 126 citations

OX40 Ligation Enhances Primary and Memory Cytotoxic T Lymphocyte Responses in an Immunotherapy for Hepatic Colon Metastases

2002 • 115 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules

1997 • 106 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.

2002 • 71 citations

OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response

2003 • 67 citations

Antitumor Responses Induced by Transgenic Expression of CD40 Ligand

1997 • 66 citations

Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway.

2004 • 65 citations

Functional CD4 T Cells after Intercellular Molecular Transfer of OX40 Ligand

2001 • 62 citations

Autologous Antileukemic Immune Response Induced by Chronic Lymphocytic Leukemia B Cells Expressing the CD40 Ligand and Interleukin 2 Transgenes

2001 • 61 citations

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells

2001 • 40 citations

Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphoma

2001 • 35 citations

CD40 Ligand Promotes Priming of Fully Potent Antitumor CD4+ T Cells in Draining Lymph Nodes in the Presence of Apoptotic Tumor Cells

2001 • 34 citations

Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40+ and CD40− plasmacytoma cells

2002 • 27 citations

Generation and ex vivo expansion of cytotoxic T lymphocytes directed toward different types of leukemia or myelodysplastic cells using both HLA-matched and partially matched donors

2003 • 27 citations

Bystander Transfer of Functional Human CD40 Ligand from Gene-Modified Fibroblasts to B-Chronic Lymphocytic Leukemia Cells

2003 • 26 citations