Characterization and functional study of five novel monoclonal antibodies against human OX40L highlight reverse signalling: enhancement of IgG production of B cells and promotion of maturation of DCs

Production of monoclonal antibodies: Strategy and tactics

1980 • 1,594 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.

1996 • 284 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in `reverse signalling'

1999 • 198 citations

Reverse signaling via CD30 ligand.

1996 • 184 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

OX-40: life beyond the effector T cell stage

1998 • 152 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax.

1991 • 141 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

Expression of the T-Cell Activation Antigen, OX-40, Identifies Alloreactive T Cells in Acute Graft-Versus-Host Disease

1997 • 83 citations

CD134L Engagement Enhances Human B Cell Ig Production: CD154/CD40, CD70/CD27, and CD134/CD134L Interactions Coordinately Regulate T Cell-Dependent B Cell Responses

2000 • 78 citations

Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease

1998 • 59 citations

Intracellular Signaling of gp34, the OX40 Ligand: Induction of c-junand c-fosmRNA Expression Through gp34 upon Binding of Its Receptor, OX40

1999 • 48 citations

Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation

2001 • 47 citations

Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

2001 • 41 citations

An agonist anti-human CD40 monoclonal antibody that induces dendritic cell formation and maturation and inhibits proliferation of a myeloma cell line.

1999 • 36 citations

Expression of CD134 (0X-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease

1999 • 29 citations