Asthma: an epidemic of dysregulated immunity

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Hay fever, hygiene, and household size.

1989 • 4,910 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

2001 • 2,461 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years

1999 • 1,635 citations

Allergy, Parasites, and the Hygiene Hypothesis

2002 • 1,543 citations

Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey

2001 • 1,488 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Consequences of Cell Death

2000 • 1,382 citations

Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy

1999 • 1,341 citations

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

2001 • 1,331 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

2002 • 1,108 citations

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.

1997 • 1,088 citations

Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)

2002 • 1,062 citations

Role of interleukin 10 in specific immunotherapy.

1998 • 980 citations

Siblings, Day-Care Attendance, and the Risk of Asthma and Wheezing during Childhood

2000 • 947 citations

The intestinal microflora in allergic Estonian and Swedish 2‐year‐old children

1999 • 937 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

2000 • 837 citations

Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study

2001 • 791 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study

2000 • 697 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis a virus

1997 • 529 citations

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

2002 • 528 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Skin test reactivity and number of siblings

1994 • 502 citations

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

2001 • 487 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity

2000 • 394 citations

The environmental predictors of allergic disease

2000 • 381 citations

The alliance of genes and environment in asthma and allergy

1999 • 370 citations

Grain Feeding and the Dissemination of Acid-Resistant Escherichia coli from Cattle

1998 • 367 citations

Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli

1996 • 331 citations

CD4 T-Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic Status

1990 • 327 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1996 • 311 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

Early exposure to infections and antibiotics and the incidence of allergic disease: A birth cohort study with the West Midlands General Practice Research Database

2002 • 274 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation

2000 • 272 citations

T1 and T2 CD4+ cells in human allergic diseases

1997 • 269 citations

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

2001 • 264 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Exposure to endotoxin decreases the risk of atopic eczema in infancy: A cohort study

2001 • 249 citations

Characterization of Human Inducible Costimulator Ligand Expression and Function

2000 • 237 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation

2002 • 219 citations

The mucosal milieu creates tolerogenic dendritic cells and TR1 and TH3 regulatory cells

2001 • 209 citations

IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

2000 • 203 citations

Airway inflammation and remodeling in asthma

2000 • 197 citations

Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment☆☆☆★★★

1998 • 194 citations

T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties

2000 • 178 citations

Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria

1998 • 178 citations

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

2000 • 176 citations

Intranasal Exposure to Protein Antigen Induces Immunological Tolerance Mediated by Functionally Disabled CD4+ T Cells

1999 • 174 citations

High Levels of Spontaneous and Parasite Antigen-Driven Interieukin-10 Production Are Associated with Antigen-Specific Hyporesponsiveness in Human Lymphatic Filariasis

1996 • 168 citations

Relationship of viral infections to wheezing illnesses and asthma

2002 • 159 citations

Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction.

1982 • 157 citations

Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial☆☆☆★

1999 • 157 citations

Aerosol-induced Immunoglobulin (Ig)-E Unresponsiveness to Ovalbumin Does Not Require CD8+ or T Cell Receptor (TCR)-γ/δ+ T Cells or Interferon (IFN)-γ in a Murine Model of Allergen Sensitization

1998 • 155 citations

Suppression of Asthma-like Responses in Different Mouse Strains by Oral Tolerance

2001 • 150 citations

CD4 T Lymphocyte Activation in Acute Severe Asthma

1991 • 141 citations

Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions☆☆☆★

1999 • 99 citations

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

1997 • 92 citations

TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia.

1997 • 90 citations

Mechanisms preventing allergen-induced airways hyperreactivity: Role of tolerance and immune deviation

2000 • 89 citations

Genes other than TLR4 are involved in the response to inhaled LPS

2001 • 81 citations

Critical role of CD81 in cognate T–B cell interactions leading to Th2 responses

2002 • 75 citations

Respiratory Infection with Influenza A Virus Interferes with the Induction of Tolerance to Aeroallergens

2000 • 73 citations

Critical role of B cells in the development of T cell tolerance to aeroallergens

2002 • 69 citations

Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells

1997 • 55 citations

Modulation of Inhaled Antigen-Induced IgE Tolerance by Ongoing Th2 Responses in the Lung

2001 • 42 citations

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