Interleukin-2 as a neuroregulatory cytokine

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Cytokine receptor signalling

1995 • 1,242 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

The cytokine handbook

1994 • 1,121 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

1993 • 561 citations

The immune system as a sensory organ.

1984 • 555 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro.

1996 • 493 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1987 • 456 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

1991 • 449 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

Immunoregulators in the nervous system

1991 • 380 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Clinical effects and toxicity of interleukin-2 in patients with cancer

1986 • 359 citations

The interleukin-2 receptor.

1991 • 354 citations

Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines.

1989 • 349 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Interleukins-1 and -6 Stimulate the Release of Corticotropin-Releasing Hormone-41 from Rat Hypothalamusin Vitrovia the Eicosanoid Cyclooxygenase Pathway*

1991 • 331 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

1989 • 323 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Molecular cloning of human interleukin 2 cDNA and its expression inE. coli

1983 • 307 citations

Cytokines and the nervous system I: expression and recognition

1995 • 307 citations

Chemoattraction of human blood T lymphocytes by interleukin-15.

1995 • 303 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Cytokine structural taxonomy and mechanisms of receptor engagement

1993 • 252 citations

Intratumoral LAK cell and interleukin-2 therapy of human gliomas

1989 • 252 citations

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

1986 • 251 citations

Three-Dimensional Structure of Interleukin-2

1987 • 242 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Interleukin 2 and its receptors: recent advances and new immunological functions

1996 • 241 citations

Cytokine mRNA expression in inflammatory multiple sclerosis lesions: Detection by non-radioactive in situ hybridization

1993 • 239 citations

Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2

1994 • 222 citations

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 • 220 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

Cytokine-regulated proteases in autoimmune diseases

1994 • 214 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma.

1993 • 211 citations

Pharmacokinetics of recombinant interleukin 2 in humans.

1990 • 210 citations

Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines.

1980 • 210 citations

Immune-neuroendocrine circuits: integrative role of cytokines.

1992 • 207 citations

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

1993 • 207 citations

Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status

1995 • 203 citations

Immunoendocrine Communication via the Hypothalamo-Pituitary-Adrenal Axis in Autoimmune Diseases*

1993 • 196 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Immune Disturbances during Major Depression: Upregulated Expression of Interleukin-2 Receptors

1990 • 192 citations

Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells.

1990 • 191 citations

Peptide Growth Factors and Their Receptors I

1990 • 187 citations

Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

1986 • 184 citations

Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami.

1993 • 184 citations

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

1989 • 179 citations

Prolactin Induction of Interleukin-2 Receptors on Rat Splenic Lymphocytes*

1990 • 178 citations

Interleukin-2

1993 • 175 citations

The Immune Logical Brain

1987 • 175 citations

Blood to brain transport of interleukin links the immune and central nervous systems

1991 • 174 citations

Immunosuppression by Glucocorticoids: Inhibition of Production of Multiple Lymphokines by in Vivo Administration of Dexamethasone

1993 • 173 citations

Cytokines and neuropathology

1992 • 172 citations

Involvement of cytokines in acute neurodegeneration in the CNS

1993 • 169 citations

Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier

1994 • 167 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6.

1993 • 163 citations

Somatostatin and the immune and haematopoetic system; a review

1994 • 162 citations

Expression of cytokine receptors in cultured neuronal and glial cells

1993 • 161 citations

Associations between the neuroendocrine and immune systems

1995 • 159 citations

Requirement of Nuclear Prolactin for Interleukin-2—Stimulated Proliferation of T Lymphocytes

1991 • 156 citations

Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor.

1989 • 154 citations

Stimulatory effect of corticotropin-releasing neurohormone on human lymphocyte proliferation and interleukin-2 receptor expression

1989 • 151 citations

Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells.

1987 • 150 citations

Cross talk between the immune system and the nervous system in response to injury: implications for regeneration

1994 • 149 citations

Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20

1989 • 145 citations

Peptide Growth Factors and Their Receptors I

1991 • 145 citations

Prostaglandin-Dependent in Vitro Stimulation of Adrenocortical Steroidogenesis by Interleukins*

1991 • 145 citations

Phase I evaluation of recombinant interleukin-2 in patients with advanced malignant disease.

1986 • 144 citations

Formation of Ion-Permeable Channels by Tumor Necrosis Factor-α

1992 • 143 citations

Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.

1995 • 142 citations

Lowest dose interleukin-2 immunotherapy [see comments]

1993 • 141 citations

The Neuroendocrine Effects of Interleukin-2 Treatment

1989 • 140 citations

Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter.

1994 • 139 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

1994 • 137 citations

Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

1988 • 137 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15

1995 • 135 citations

Anterior pituitary hormone control by interleukin 2.

1991 • 134 citations

Immune system associated antigens expressed by cells of the human central nervous system

1988 • 132 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

Systemic cytokine administration can affect blood-brain barrier permeability in the rat

1995 • 131 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells

2011 • 130 citations

Glycosylphosphatidylinositol: A Candidate System for Interleukin-2 Signal Transduction

1991 • 129 citations

Regulation of Human B Lymphocyte Activation, Proliferation, and Differentiation

1987 • 129 citations

Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

1990 • 128 citations

A Transglutaminase That Converts Interleukin-2 into a Factor Cytotoxic to Oligodendrocytes

1993 • 125 citations

JAK protein tyrosine kinases: their role in cytokine signalling

1994 • 125 citations

Cytokines Regulate L‐Arginine‐Dependent Cyclic GMP Production in Rat Glial Cells

1993 • 124 citations

Mechanism of action of glucocorticosteroids. Inhibition of T cell proliferation and interleukin 2 production by hydrocortisone is reversed by leukotriene B4.

1986 • 123 citations

Isolation and characterization of a primitive interleukin-1-like protein from an invertebrate, Asterias forbesi.

1986 • 123 citations

Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus

1990 • 123 citations

Behavioural and ECoG spectrum changes induced by intracerebral infusion of interferons and interleukin 2 in rats are antagonized by naloxone

1990 • 116 citations

Glucocorticoids accelerate anti-T cell receptor-induced T cell growth.

1995 • 115 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

Is interleukin 2 a neuromodulator in the brain?

1991 • 111 citations

Interleukin‐2 Modulates Evoked Release of [³H]Dopamine in Rat Cultured Mesencephalic Cells

1993 • 111 citations

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

1991 • 111 citations

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

1994 • 111 citations

Lowest dose interleukin-2 immunotherapy [see comments]

1993 • 110 citations

Recovery of Visual Response of Injured Adult Rat Optic Nerves Treated with Transglutaminase

1994 • 110 citations

Transforming growth factor‐βs inhibit mitogen‐stimulated proliferation of astrocytes

1993 • 109 citations

Cytokines and hypothalamic-pituitary function

1993 • 109 citations

Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects

1983 • 109 citations

Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures.

1992 • 109 citations

Cytokines in neuronal cell types

1993 • 108 citations

Interleukin-15 gene expression in human astrocytes and microglia in culture

1996 • 107 citations

Cytokines and the hypothalamic—pituitary—ovarian—endometrial axis

1994 • 107 citations

Interleukin-2 gene therapy in a patient with glioblastoma.

1995 • 107 citations

Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2

1993 • 107 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage

1994 • 107 citations

A role for interleukin-2 in the regulation of striatal dopaminergic function

1992 • 107 citations

Adoptive immunotherapy for recurrent glioblastoma multiforme using lymphokine activated killer cells and recombinant interleukin-2

1988 • 106 citations

The blood-brain barrier. Cellular and molecular biology

1994 • 105 citations

Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro.

1986 • 103 citations

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

1992 • 103 citations

The Blood-brain barrier : cellular and molecular biology

1993 • 102 citations

Extended continuous infusion low-dose recombinant interleukin-2 in advanced cancer: prolonged immunomodulation without significant toxicity.

1991 • 101 citations

A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma

1994 • 100 citations

The Multichain Interleukin-2 Receptor: A Target for Immunotherapy

1992 • 100 citations

IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling

1994 • 99 citations

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.

1990 • 98 citations

Clinical Toxicity of Interleukin-2

1992 • 98 citations

Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor.

1995 • 96 citations

Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins.

1994 • 95 citations

Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling.

1992 • 93 citations

Intralesional Infusion of Lymphokine-activated Killer (LAK) Cells and Recombinant Interleukin-2 (rIL-2) for the Treatment of Patients with Malignant Brain Tumor

1988 • 93 citations

Role of tyrosine kinases in lymphocyte activation

1994 • 91 citations

Interleukin-2

1992 • 91 citations

Adhesion receptors in lymphocyte activation

1994 • 90 citations

Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation

1996 • 90 citations

IL-2-induced signal transduction involves the activation of nuclear NF-kappa B expression.

1992 • 89 citations

Action site of circulating interleukin-1 on the rabbit brain

1991 • 89 citations

Direct involvement of p53 in programmed cell death of oligodendrocytes.

1995 • 89 citations

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid

1989 • 88 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

Interleukin-2 in cancer treatment: Disappointing or (still) promising? A review

1993 • 86 citations

Interleukin-2 does not cross the blood-brain barrier by a saturable transport system

1994 • 86 citations

Induction by Cytokines of the Pattern of Pituitary Hormone Secretion in Infection

1994 • 85 citations

Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children

1991 • 84 citations

Response : Unraveling the Structure of IL-2

1992 • 84 citations

Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice

1994 • 84 citations

Cytokines and autoimmune disease

1991 • 84 citations

Interleukin-1α in blood has direct access to cortical brain cells

1993 • 84 citations

Primitive cytokines: harbingers of vertebrate defense

1991 • 83 citations

Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.

1992 • 83 citations

Lymphokines in Autoimmunity—A Critical Review

1994 • 82 citations

Adoptive Immunotherapy for Cancer

1990 • 81 citations

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.

1993 • 81 citations

Macroglia: neural cells responsive to lymphokines and growth factors

1987 • 80 citations

Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes

1990 • 80 citations

Interleukin-2, Autotolerance, and Autoimmunity

1991 • 79 citations

Expression of cytokines during glial differentiation

1994 • 79 citations

Developmental expression of cytokine genes in the cortex and hippocampus of the rat central nervous system

1994 • 77 citations

Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene.

1995 • 77 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

1992 • 76 citations

Interleukin‐2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain

1993 • 76 citations

Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-?. Results of a phase I clinical trial

1992 • 75 citations

Changes in plasma cytokines associated with peripheral nerve injury

1992 • 74 citations

Cytokine receptors on glial cells

1994 • 74 citations

Altered interleukin-2 production in schizophrenia: Association between clinical state and autoantibody production

1992 • 72 citations

Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain

1993 • 72 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor.

1990 • 68 citations

Cytokines in the central nervous system: Expression of macrophage colony stimulating factor and its receptor during development

1994 • 68 citations

Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement.

1989 • 68 citations

Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way [see comments]

1994 • 67 citations

Loco-regional immunotherapy with recombinant interleukin-2 and adherent lymphokine-activated killer cells (A-LAK) in recurrent glioblastoma patients

1994 • 67 citations

Hypothalamic-pituitary-adrenocortical axis activity and immune function after oral exposure to benzene and toluene

1991 • 66 citations

Human recombinant interleukin-2 as an experimental therapeutic.

1990 • 66 citations

Evidence for a Critical Role for the Cytoplasmic Region of the Interleukin 2 (IL-2) Receptor γ Chain in IL-2, IL-4, and IL-7 Signalling

1994 • 65 citations

Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus

1988 • 65 citations

Interleukin‐2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth

1990 • 65 citations

Partial agonist/antagonist mouse interleukin-2 proteins indicate that a third component of the receptor complex functions in signal transduction.

1990 • 64 citations

Interleukin-2-like activity in injured rat brain

1987 • 64 citations

Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration

1993 • 63 citations

Parallel Induction of Nitric Oxide and Tetrahydrobiopterin Synthesis by Cytokines in Rat Glial Cells

1995 • 63 citations

A tyrosine kinase physically associates with the β-subunit of the human IL-2 receptor

1991 • 62 citations

IL-15: the role of translational regulation in their expression

1996 • 62 citations

Induction of Functional Interleukin‐2 Receptor in Mouse Microglia

1995 • 62 citations

The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.

1994 • 61 citations

The effect of intravenous interleukin-2 on brain water content

1989 • 61 citations

Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6

1993 • 60 citations

Increased serum soluble interleukin-2 receptors in caucasian and Korean schizophrenic patients

1994 • 60 citations

Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by substance P

1992 • 60 citations

Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck

1993 • 60 citations

Studies of neuroimmune markers in Alzheimer's disease

1994 • 59 citations

Transient focal neurologic deficits complicating interleukin‐2 therapy

1990 • 59 citations

The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.

1995 • 59 citations

Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: Complete response in a patient with Hodgkin's disease refractory to chemotherapy

1994 • 59 citations

The interleukins-1α, -1β, and -2 do not acutely disrupt the murine blood - brain barrier

1992 • 59 citations

Regulation of Clusterin Secretion and mRNA Expression in Astrocytes by Cytokines

1994 • 59 citations

Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cells

1989 • 58 citations

Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration.

1992 • 58 citations

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

1992 • 58 citations

The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit.

1992 • 57 citations

Interleukin‐2 Transcripts in Human and Rodent Brains: Possible Expression by Astrocytes

1995 • 56 citations

Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex.

1996 • 56 citations

Interaction of HIV gp120 and anti‐CD4 antibodies with the CD4 molecule on human CD4⁺ T cells inhibits the binding activity of NF‐AT, NF‐χB and AP‐1, three nuclear factors regulating interleukin‐2 gene enhancer activity

1994 • 55 citations

Selective Elimination of HIV-1-Infected Cells with an Interleukin-2 Receptor-Specific Cytotoxin

1991 • 55 citations

SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.

1994 • 54 citations

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 • 53 citations

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.

1995 • 53 citations

Interleukin‐2 Effects in the Central Nervous Systema

1990 • 53 citations

Histopathological and blood-brain barrier changes in rats induced by an intracerebral injection of human recombinant interleukin 2

1989 • 53 citations

An anti-IL-2 antibody increases serum halflife and improves anti-tumor efficacy of human recombinant interleukin-2

1994 • 52 citations

Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human Receptors

1993 • 52 citations

A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor.

1991 • 51 citations

Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes

1992 • 51 citations

Adrenocorticotropic hormone-releasing activities of interleukins in a homologous invivo system

1989 • 51 citations

Differential central nervous system responses folloqing single and multiple recombinant interleukin-2 infusions

1990 • 51 citations

Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice

1992 • 51 citations

Protein tyrosine kinases, with emphasis on the Src family.

1994 • 50 citations

Cytokines and their receptor complexes

1995 • 50 citations

Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation.

1994 • 50 citations

Molecular cloning of a partial cDNA of the interleukin-2 receptor-β in normal mouse brain: in situ localization in the hippocampus and expression by neuroblastoma cells

1994 • 49 citations

Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.

1989 • 49 citations

Recombinant single-chain immunotoxins against T and B cell leukemias.

1994 • 49 citations

Cytokines and autoimmunity

1994 • 48 citations

Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC.

1993 • 48 citations

A novel human tyrosine kinase gene inducible in T cells by interleukin 2

1993 • 48 citations

Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4.

1992 • 48 citations

Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.

1989 • 48 citations

Systemic interleukin‐1 α and interleukin‐2 secretion in response to acute stress and to corticotropin‐releasing hormone in humans*

1994 • 48 citations

Cutaneous side effects associated with interleukin 2 administration for metastatic melanoma

1993 • 47 citations

Antihypertensive effect of interleukin-2.

1990 • 47 citations

Acute Thyroid Dysfunction (Thyroiditis) after Therapy with Interleukin-2

1992 • 46 citations

Interleukin-2 and the IL-2 Receptor: New Insight Into Structure and Function

1990 • 46 citations

Interleukin-2 enhances the viability of primary cultured rat neocortical neurons

1993 • 46 citations

Chronic Effects of Interleukin-1 on Hypothalamus, Pituitary and Adrenal Glands in Rat

1990 • 45 citations

Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia.

1993 • 45 citations

Receptor antagonist and selective agonist derivatives of mouse interleukin-2.

1992 • 45 citations

Relationship between corticotropin‐releasing factor and interleukin‐2: Evolutionary evidence

1994 • 45 citations

The soluble interleukin-2 receptor as a marker for human neoplasia and immune status.

1991 • 45 citations

An association between anti-hippocampal antibody concentration and lymphocyte production of IL-2 in patients with schizophrenia

1994 • 45 citations

Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression.

1995 • 45 citations

Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus

1993 • 43 citations

Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma

1994 • 43 citations

Current status of Interleukin-2 therapy in cancer

1992 • 43 citations

Communications among central nervous system, neuroendocrine and immune systems: Interleukin-2

1993 • 42 citations

The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

1993 • 42 citations

Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids.

1992 • 42 citations

Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2.

1994 • 41 citations

The immunobiological effects of interleukin-2 in vivo

1994 • 41 citations

Behavioral and Electrocortical Spectrum Power Effects after Microinfusion of Lymphokines in Several Areas of the Rat Brain

1991 • 41 citations

Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons

1993 • 41 citations

K‐252a Promotes Survival and Choline Acetyltransferase Activity in Striatal and Basal Forebrain Neuronal Cultures

1995 • 40 citations

Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.

1990 • 40 citations

Identification and initial characterization of an autocrine pheromone receptor in the protozoan ciliate Euplotes raikovi.

1990 • 40 citations

IL‐2‐dependent in vivo and in vitro tyrosine phosphorylation of IL‐2 receptor γ chain

1992 • 39 citations

The interleukin-2-receptors: insights into a complex signalling mechanism

1992 • 39 citations

Serum cytokine and soluble interleukin‐2 receptors in patients with panic disorder

1994 • 39 citations

Polyethylene‐glycol‐modified interleukin‐2 is superior to interleukin‐2 in locoregional immunotherapy of established guinea‐pig tumors

1992 • 39 citations

Interleukin-2 Induces Apoptosis in Mouse Thymocytes

1993 • 39 citations

Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.

1994 • 39 citations

Role of α chain - IL-2 complex in the formation of the ternary complex of IL-2 and high-affinity IL-2 receptor

1990 • 38 citations

lnterleukin-2-lnduced Changes in Behavioural, Neurotransmitter, and Immunological Parameters in the Olfactory Bulbectomized Rat

1995 • 38 citations

Effects of lnterleukin-2 on Various Models of Experimental Epilepsy in DBA/2 Mice

1994 • 38 citations

Properties of sodium dodecyl sulfate-denatured Interleukin 2.

1981 • 37 citations

Appearance of cytokine-associated central nervous system myelin damage coincides temporally with serum tumor necrosis factor induction after recombinant interleukin-2 infusion in rats

1991 • 37 citations

lnterleukin-2: Solid-Tumor Therapy

1994 • 37 citations

Active microglia, sick astroglia and Alzheimer type dementias

1994 • 37 citations

Accumulation of adoptively transferred A-NK cells in murine metastases: kinetics and role of interleukin-2.

1994 • 36 citations

Comparative toxicity and pathology associated with administration of recombinant IL-2 to animals.

1993 • 36 citations

Histopathological and Blood-Brain Barrier Changes in Rats Induced by an Intracerebral Injection of Human Recombinant Interleukin 2

1989 • 35 citations

Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex.

1988 • 35 citations

Effects of Peripheral Cytokine Injections on Multiple Unit Activity in the Anterior Hypothalamic Area of the Mouse

1993 • 35 citations

Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2.

1992 • 34 citations

Interleukin-2 and the Interleukin-2 Receptor Complex

2015 • 34 citations

Interleukin-2 receptor heterotrimer complex and intracellular signaling

1993 • 33 citations

Cytokine receptors and signal transduction

1994 • 32 citations

Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes

1994 • 31 citations

Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-l-infected human T cells

1992 • 31 citations

Leucocyte recruitment and inflammation in the CNS

1992 • 30 citations

Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits.

1994 • 30 citations

The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways.

1988 • 30 citations

A monoclonal antibody to the interleukin-2 receptor enhances the survival of neural allografts: A time-course study

1992 • 30 citations

Interleukin-2 Gene Transfer into Murine Neuroblastoma Decreases Tumorigenicity and Enhances Systemic Immunity Causing Regression of Preestablished Retroperitoneal Tumors

1994 • 30 citations

Delayed neurotoxicity of intraventricular interleukin-2: A case report

1993 • 30 citations

lnterleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse

1993 • 29 citations

Interleukin-2 inhibits sodium currents in human muscle cells

1992 • 29 citations

Neuro-ophthalmic Complications of Interleukin 2 Therapy

1991 • 29 citations

Endocrine effects of a 24-hour intravenous infusion of interleukin-2 in the immunotherapy of cancer.

1990 • 29 citations

Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin‐2

1994 • 29 citations

Myelin Basic Protein‐Specific RNA Levels in Interleukin‐2‐Stimulated Oligodendrocytes

1987 • 28 citations

The influence of interleukin-2 on vasopressin and oxytocin gene expression in the rodent hypothalamus

1993 • 28 citations

Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytes

1989 • 28 citations

Partial purification and characterization of chicken interleukin-2

1992 • 28 citations

T-cell development and function in gene-knockout mice

1994 • 27 citations

Comparative activation requirements of human peripheral blood, spleen, and lymph node B cells.

1987 • 27 citations

Interleukin-2 bolus therapy induces immediate and selective disappearance from peripheral blood of all lymphocyte subpopulations displaying natural killer activity: Role of cell adhesion to endothelium

1992 • 27 citations

Transmembrane signalling by interleukin 2

1991 • 27 citations

Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary

1992 • 27 citations

Mutagenic Analysis of a Receptor Contact Site on Interleukin-2: Preparation of an IL-2 Analog with Increased Potency

1994 • 26 citations

Reversible neurotoxicity of interleukin-2 and tumor necrosis factor: correlation of SPECT with neuropsychological testing

1994 • 26 citations

IL-2 receptor subunit, p75: direct demonstration of its IL-2 binding ability by using a novel monoclonal antibody

1989 • 26 citations

Cytokines in the Healthy and Diseased Brain

1994 • 26 citations

Immunotherapy of tumor metastasis via gene therapy.

1994 • 26 citations

Local anaesthetic-like effect of interleukin-2 on muscular Na+ channels: no evidence for involvement of the IL-2 receptor

1994 • 26 citations

Phase II Trial of High-Dose Interleukin-2 and Lymphokine-Activated Killer Cells in Hodgkin??s Disease and Non-Hodgkin??s Lymphom

1991 • 26 citations

G proteins in lymphocyte signalling

1994 • 25 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 25 citations

The effect of interleukin-2 on the blood-brain barrier in the 9L gliosarcoma rat model

1989 • 25 citations

Sterile abscesses in glioma patients treated by intraparenchymal injection of lymphokine-activated killer cells and recombinant interleukin-2

1989 • 24 citations

Receptor binding and internalization of mouse interleukin-2 derivatives that are partial agonists.

1992 • 24 citations

Implication of Protein Kinase C in IL-2-Mediated Proliferation and Apoptosis in a Murine T Cell Clone

1994 • 24 citations

Interleukin‐2 inhibition of oligodendrocyte progenitor cell proliferation depends on expression of the TAC receptor

1987 • 24 citations

Interleukins modulate glucocorticoid-induced thymocyte apoptosis

1992 • 24 citations

The Influence of lnterleukin-2 on the Release of Somatostatin and Growth Hormone-Releasing Hormone by Mediobasal Hypothalamus

1993 • 23 citations

Interleukin-2 and phytohaemagglutinin stimulate proliferation of tunicate cells

1991 • 23 citations

Unexpected effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog.

1993 • 23 citations

Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2

1994 • 23 citations

Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids

1992 • 23 citations

Neurotoxicity induced by interleukin-2: Involvement of infiltrating immune cells

1996 • 23 citations

Corticosteroids inhibit the generation of lymphokine-activated killer activity in vitro

1989 • 23 citations

Molecular cloning of IL‐2Rα, IL‐2Rβ, and IL‐2Rγ cDNAs from a human oligodendroglioma cell line: Presence of IL‐2R mRNAs in the human central nervous system

1995 • 23 citations

Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.

1993 • 23 citations

Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation

1994 • 23 citations

Increased soluble interleukin 2 receptor levels in autoimmune thyroid disease

1991 • 23 citations

Unexpected Effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog

1993 • 23 citations

Interleukin-2 secreting cells in multiple sclerosis and controls

1993 • 23 citations

Thymosin fraction 5 (TF5) stimulates secretion of adrenocorticotropic hormone (ACTH) from cultured rat pituitaries

1988 • 22 citations

Local lnterleukin-2 Therapy for Cancer, and Its Effector Induction Mechanisms

1994 • 22 citations

Cytokine mRNA in Brain Tissue from Mice that Show Strain-Dependent Differences in the Severity of Lesions Induced by Systemic Infection with Candida albicans Yeast

1995 • 21 citations

The interleukin-2 receptor complex and signal transduction: role of the β-chain

1993 • 21 citations

The Role of Diacylglycerol Kinase Activation and Phosphatidate Accumulation in Interleukin-2-Dependent Lymphocyte Proliferation

1993 • 21 citations

Interleukin-2 stimulates the secretion of arginine vasopressin but not corticotropin-releasing hormone from rat hypothalamic cells in vitro

1994 • 21 citations

Biotinylated recombinant interleukin-2

1988 • 21 citations

Interleukin‐2 inhibits the GABA‐induced Cl^‐ current in identified Aplysia neurons

1992 • 21 citations

Cerebrovascular Effects and Tumor Kinetics after a Single Intratumoral Injection of Human Recombinant Interleukin-2 Alone or in Combination with Intravenous Chemotherapy in a Rat Model of Glioma

1992 • 21 citations

Cytokine receptors: a combinative family of molecules.

1994 • 21 citations

Adoptive immunotherapy of cancer: biological response modifiers and cytotoxic cell therapy

1992 • 20 citations

Cross-species PCR cloning of gerbil (Meriones unguiculatus) interleukin-2 cDNA and its expression in COS-7 cells

1994 • 20 citations

Interleukin-2: Its Biology and Clinical Application in Patients with Cancer

1993 • 20 citations

Functional, biochemical, and histopathologic consequences of high-dose interleukin-2 administration in rats.

1991 • 20 citations

Evaluation of IL-2, sIL2R, IL-6, TNF-α, and IL-1β levels in serum and CSF of patients with optic neuritis

1992 • 20 citations

Inhibition of lnterleukin-2-Mediated Lymphocyte Activation in Patients with Cushing’s Syndrome: A Comparison with Hypocortisolemic Patients

1994 • 20 citations

Regulation of the Human Interleukin-2/Interleukin-2 Receptor System: A Role for Immunosuppression

1994 • 20 citations

Role of Cytokines in the Endocrine System

1994 • 20 citations

Serum soluble interleukin 2 receptor in systemic lupus erythematosus: effects of disease activity and infection.

1991 • 20 citations

Adoptive immunotherapy of intracerebral metastases in mice

1990 • 20 citations

Interleukin-2-induced enhancement of an antigen-specific IgM plaque-forming cell response is mediated by the sympathetic nervous system.

1994 • 20 citations

Immunotoxins and recombinant toxins in the treatment of solid carcinomas

1993 • 19 citations

Influence of Dopamine on the Altered Release of Prolactin, Luteinizing Hormone, and Follicle-Stimulating Hormone Induced by Interleukin-2 in vitro

1992 • 19 citations

Effective immunotherapy with local low doses of interleukin-2.

1991 • 19 citations

Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture

1992 • 19 citations

Enhanced survival and differentiation in vitro of different neuronal populations by some interleukins

1995 • 19 citations

Recombinant interleukin‐2 (rIL‐2) in acquired immune deficiency syndrome (AIDS): Preliminary report in patients with lymphoma associated with HIV infection

1992 • 18 citations

Molecular cloning of the coding sequence of an interleukin-2 receptor α subunit cDNA in murine brain

1995 • 18 citations

Purification and initial characterization of rat interleukin 2.

1982 • 18 citations

Comparison of anti-Tac and anti-transferrin receptor-conjugated liposomes for specific drug delivery to adult T-cell leukemia

1989 • 18 citations

Trauma-induced glial proliferation: Possible involvement of the immune system

1982 • 17 citations

Amino acid sequence homology between ligands and their receptors: potential identification of binding sites

1989 • 17 citations

Interleukin-2: A Possible Trigger for Autoimmunity

1992 • 17 citations

Gs is the major G protein involved in interleukin-2-activated natural killer (IANK) cell-mediated cytotoxicity. Successful introduction of anti-G protein antibodies inside streptolysin O-permeabilized IANK cells.

1994 • 17 citations

Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro

1991 • 17 citations

Interleukin 2 mediates p72^syk activation in peripheral blood lymphocytes

1994 • 16 citations

Suppression of immune responses to acetylcholine receptor by interleukin 2-fusion toxin: in vivo and in vitro studies

1991 • 16 citations

Neurologic complications of cytokine therapy.

1994 • 16 citations

The role of IL-2 in gene therapy.

1994 • 15 citations

Cytokines in the pathogenesis of multiple sclerosis.

1992 • 15 citations

Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression

1995 • 15 citations

Decreased IL-3 production by peripheral blood mononuclear cells in patients with multiple sclerosis

1993 • 15 citations

Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor γ

1993 • 15 citations

T-lymphocyte proliferation: tyrosine kinases in interleukin 2 signal transduction

1992 • 15 citations

Cell type‐specific tyrosine phosphorylation of IL‐2 receptor β chain in response to IL‐2

1992 • 15 citations

Characterization of a tyrosine kinase activity associated with the high-affinity interleukin 2 receptor complex

1992 • 15 citations

Cytokine gene transduction in tumor cells: interleukin (IL)-2 or IL-4 gene transfer in human melanoma cells.

1994 • 14 citations

Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration

1996 • 14 citations

Natural killer cells and gene therapy: potential of gene transfection for optimizing effector cell functions and for targeting gene products into tumor metastases.

1994 • 14 citations

Murine studies using polyethylene glycol-modified recombinant human interleukin 2 (PEG-IL-2): antitumor effects of PEG-IL2 alone and in combination with adoptive cellular transfer.

1991 • 14 citations

Reduction of the acetylcholine-induced K+ current in identifiedAplysia neurons by human interleukin-1 and interleukin-2

1992 • 13 citations

lnterleukin-2 and the lnterleukin-2 Receptor Complex

1994 • 13 citations

The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction.

1992 • 13 citations

Cerebral vasomotor responses after recombinant interleukin 2 infusion.

1990 • 13 citations

The human interleukin-2 receptor: insights into subunit structure and growth signal transduction.

1990 • 13 citations

Interleukin 2 suppresses afferent sensory transmission in the primary somatosensory cortex

1995 • 13 citations

Immunotherapy of autoimmune disease

1993 • 13 citations

In vivo biological results of the association between interleukin-2 and interleukin-3 in the immunotherapy of cancer

1993 • 12 citations

Interleukin-2 and blood brain barrier in cats: pharmacokinetics and tolerance following intrathecal and intravenous administration.

1992 • 12 citations

Interleukin-2, a pro-autoimmune lymphokine that interferes with post-deletional tolerance.

1992 • 12 citations

IL-2 production by B cells stimulated with a specific antigen

1991 • 12 citations

Interleukin-2 lengthens extrajunctional acetylcholine receptor channel open time in mammalian muscle cells

1991 • 12 citations

Glucocorticoids modulate soluble interleukin-2 receptor levels in vivo depending on the state of immune activation and the duration of glucocorticoid exposure

1993 • 11 citations

Cytokine gene therapy.

1994 • 11 citations

The Current Use of Interferons, Interleukin-2 and Tumor Necrosis Factor in Renal Cell Cancer

1991 • 11 citations

Solid phase interleukin 2

1991 • 11 citations

Serine-Rich Region of the IL-2 Receptor β-Chain Is Required for Activation of Phosphatidylinositol 3-Kinase

1994 • 11 citations

Modulation of interleukin-2-driven proliferation of human large granular lymphocytes by carbaryl, an anticholinesterase insecticide*1, *2

1991 • 11 citations

Autoimmunity as a Complication of Interleukin 2 Immunotherapy

1994 • 10 citations

Interleukin-2-dependent phosphorylation of the retinoblastoma-susceptibility-gene product p110-115RB in human T-cells

1992 • 10 citations

MHC class I-hormone receptor associations: still a physiological enigma?

1994 • 10 citations

Tolerance and cerebrospinal fluid pharmacokinetics of intrathecally administered human natural interleukin-2: a phase I trial.

1993 • 10 citations

In vivo modulation of myelin gene expression by human recombinant IL-2

1992 • 10 citations

Administration of high-dose recombinant interleukin 2 after autologous bone marrow transplantation in patients with neuroblastoma: toxicity, efficacy and survival. A Lyon-Marseille-Curie-east of France Group Study.

1994 • 10 citations

Visualization of interleukin-2-like molecules in MPP+-lesioned rat brain

1989 • 9 citations

Expression of HLA-DR and interleukin-2 receptor on reactive microglia in senile dementia of the alzheimer's type

1987 • 9 citations

The Interleukin‐2 Receptor: A Target for Immunotherapy

1993 • 9 citations

The role of receptor-ligand endocytosis and degradation in interleukin-2 signaling and T-lymphocyte proliferation.

1991 • 9 citations

Neurotoxicity of antitumoral IL-2 therapy: Evoked cognitive potentials and brain mapping

1994 • 8 citations

Sterile Abscesses in Glioma Patients Treated by Intraparenchymal Injection of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2: Case Reports

1989 • 8 citations

A chimeric mouse/human anti-IL-2 receptor antibody with enhanced biological activities

1992 • 8 citations

The evidence for the IL-2 recptor β Chain processing from p70 to p75

1990 • 8 citations

Treatment with bovine follicular fluid suppresses follicular development in gonadotrophin-releasing hormone-treated anoestrous ewes

1988 • 8 citations

Purification and characterization of two forms of rat interleukin-2

1988 • 7 citations

Lymphokine receptor-directed therapy: A model for immune intervention in leukemia, autoimmunity, and immunodeficiency

1991 • 7 citations

Cytokines in the clinics. Choose your weapon!

1994 • 7 citations

Structure and analysis of the 5′ flanking region of the human interleukin-2 gene

1994 • 7 citations

Inhibitory effect of interleukin-3 on interleukin-2-induced cortisol release in the immunotherapy of cancer.

1992 • 7 citations

Substance P stabilizes interleukin-2 mRNA in activated Jurkat cells

1994 • 7 citations

Targeting Human IL-2 Receptors for Diagnosis and Therapy

1994 • 6 citations

Methods in neurosciences

1991 • 6 citations

Mechanisms of tumor regression induced by low doses of interleukin-2.

1991 • 6 citations

Activity of liposomal interleukin-2 in vitro.

1992 • 6 citations

Anatomical and Functional Approaches to Study of Interleukin 2 and Its Receptors in Brain

1993 • 6 citations

[Effects of interleukin-1 and interleukin-2 on electrophysiological characteristics of rat hippocampal neurons in culture].

1994 • 6 citations

Interleukin-2: counteracting pleiotropy by compartmentalization.

1991 • 6 citations

Protooncogene-encoded protein kinases in interleukin-2 signal transduction

1993 • 5 citations

Autoimmunity as a complication of interleukin 2 immunotherapy. Many unanswered questions

1994 • 5 citations

[Lymphokine-activated killer (LAK) therapy for advanced renal cell carcinoma: clinical study on arterial LAK therapy and experimental study on LAK cell activity].

1992 • 5 citations

Detection of intracellular interleukin 2: Evidence for novel immunologically related forms of the lymphokine

1994 • 5 citations

Neurobiology of Cytokines - Part A

1993 • 5 citations

Linear dimeric interleukin-2 obtained by the use of a defective herpes simplex viral vector: conformation-activity relationship

1994 • 4 citations

Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha.

1994 • 4 citations

Naloxone antagonizes behavioural and ECoG effects induced by systemic or intracerebral administration of some lymphokines.

1990 • 4 citations

Behavioral and Electrocortical Power Spectrum Effects after Intracerebral Microinfusion of Interleukin-2 in Rats Are Antagonized by Naloxone

1990 • 4 citations

Bellini, carpaccio, and receptors in the central nervous system

1991 • 4 citations

Aumento dos receptores solúveis da interleucina-2 na esclerose múltipla: estudo preliminar em 26 pacientes

1994 • 3 citations

Interleukin-2 receptor signal transduction: translocation of active serine-threonine kinase Raf-1 from IL-2 receptor into cytosol depends on IL-2-induced tyrosine kinase activation.

1993 • 3 citations

Radioiodination of interleukin 2 to high specific activities by the vapor-phase chloramine T method

1988 • 3 citations

Molecular area involved in the in-vitro dimerization of the murine p55 IL-2 receptor

1992 • 2 citations

Changes in biochemical laboratory investigation in patients treated with constant infusion recombinant interleukin-2.

1991 • 2 citations

Persistent augmentation of natural-killer-and T-cell-mediated cytotoxicity in peripheral blood mononuclear cells pulsed in vitro with high-dose recombinant interleukin-2 prior to culturing with a low maintenance dose

1994 • 2 citations

Inhibition of the calcitonin-induced outward current in identifiedAplysia neurons by interleukin-1 and interleukin-2

1994 • 2 citations

[NO TITLE AVAILABLE]

1994 • 1 citations