The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

T‐Cell Growth Factor

1980 • 917 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

The interleukin-2 receptor.

1991 • 354 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

A Monoclonal Antibody 7G7/B6, Binds to an Epitope on the Human Interleukin-2 (IL-2) Receptor That is Distinct From That Recognized by IL-2 or Anti-Tac

1985 • 236 citations

The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells.

1987 • 226 citations

Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.

1989 • 219 citations

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

1993 • 207 citations

Cytokine induction in HTLV‐I associated myelopathy and adult T‐cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis

1991 • 117 citations

Expression and role of p75 interleukin 2 receptor on human monocytes.

1990 • 111 citations

Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2.

1993 • 97 citations

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

1987 • 83 citations

Multichain Interleukin-2 Receptor: A Target for Immunotherapy in Lymphoma

1989 • 75 citations

The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit.

1992 • 57 citations

Expression of the interleukin-2 receptor on human fibroblasts and its biological significance

1992 • 49 citations

Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC.

1993 • 48 citations

Immune Receptors: Targets for Therapy of Leukemia/Lymphoma, Autoimmune Diseases and for the Prevention of Allograft Rejection

1992 • 40 citations

Role of α chain - IL-2 complex in the formation of the ternary complex of IL-2 and high-affinity IL-2 receptor

1990 • 38 citations

In utero treatment with monoclonal antibody to IL-2 receptor β-chain completely abrogates development of Thy-1⁺ dendritic epidermal cells

1992 • 36 citations

Human B lymphocytes express the p75 component of the interleukin 2 receptor

1990 • 27 citations

The IL-2 receptor present on human embryonic fibroblasts is functional in the absence of P64/IL-2R_γ chain

1993 • 25 citations

T cell receptor ligation induces interleukin (IL) 2R beta chain expression in rat CD4,8 double positive thymocytes, initiating an IL-2-dependent differentiation pathway of CD8 alpha+/beta- T cells.

1993 • 21 citations

Stepwise formation of the high-affinity complex of the interleukin 2 receptor

1990 • 17 citations

Interleukin-2 modulates the expression of lymphocyte function-associated antigen-one (LFA-1) and p150,95 during the generation of lymphokine-activated killer (LAK) cells.

1989 • 16 citations

EXPRESSION OF THE INTERLEUKIN 2 RECEPTOR β CHAIN (p75) IN RENAL TRANSPLANTATION—APPLICABILITY OF ANTMNTERLEUKIN-2 RECEPTOR β CHAIN MONOCLONAL ANTIBODY

1991 • 12 citations