The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

A humanized antibody that binds to the interleukin 2 receptor.

1989 • 624 citations

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

1983 • 605 citations

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

1990 • 590 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy.

1985 • 486 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Croonian lecture.—On immunity with special reference to cell life

1900 • 427 citations

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

1983 • 385 citations

The interleukin-2 receptor.

1991 • 354 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

1981 • 350 citations

Adult T cell leukemia in Japan

1977 • 338 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

1990 • 229 citations

Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor.

1984 • 224 citations

Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene.

1990 • 211 citations

Variation in the clinical courses of adult T-cell leukemia

1985 • 208 citations

A RANDOMIZED PROSPECTIVE TRIAL OF ANTI-TAC MONOCLONAL ANTIBODY IN HUMAN RENAL TRANSPLANTATION

1991 • 181 citations

Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity.

1989 • 169 citations

Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2

1988 • 164 citations

An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene

1991 • 154 citations

Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

1989 • 152 citations

Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders.

1990 • 150 citations

The Arrangement of Immunoglobulin and T Cell Receptor Genes in Human Lymphoproliferative Disorders

1987 • 138 citations

Cytokine induction in HTLV‐I associated myelopathy and adult T‐cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis

1991 • 117 citations

Anti-Tac-H, a humanized antibody to the interleukin 2 receptor, prolongs primate cardiac allograft survival.

1991 • 105 citations

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

1987 • 83 citations

Expression and Interactions of the Src Family of Tyrosine Protein Kinases in T Lymphocytes

1991 • 83 citations

Multichain Interleukin-2 Receptor: A Target for Immunotherapy in Lymphoma

1989 • 75 citations

Elevated Serum Levels of Soluble Tac Peptide in Adult T-Cell Leukemia: Correlation with Clinical Status during Chemotherapy

1988 • 64 citations

Interleukin-2 and the IL-2 Receptor: New Insight Into Structure and Function

1990 • 46 citations

lymphoma type adult T‐cell leukemia—a clinicopathologic study of HTLV related T‐cell type malignant lymphoma

1986 • 43 citations

Elevated serum-soluble interleukin-2 receptor (Tac antigen) levels in chronic myelogenous leukemia patients with blastic crisis

1989 • 42 citations

Monoclonal antibodies for cancer therapy.

1988 • 30 citations

Human T‐cell leukemia virus type‐I‐infected T‐cell lines scarcely produce p56^lck, whether or not they express lck MRNA

1990 • 9 citations