Regulation of Human B Lymphocyte Activation, Proliferation, and Differentiation

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

There is more than one interleukin 1

1986 • 1,226 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Characterization of a human B lymphocyte-specific antigen.

1980 • 1,098 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

1984 • 936 citations

T‐Cell Growth Factor

1980 • 917 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

1986 • 514 citations

Expression of interleukin 2 receptors on activated human B cells.

1984 • 488 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

The T Cell Dependence of B Cell Differentiation Induced by Pokeweed Mitogen

1976 • 409 citations

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

1981 • 409 citations

The clonal selection theory of acquired immunity

1960 • 396 citations

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

1983 • 385 citations

Characterization of a human B cell-specific antigen (B2) distinct from B1.

1981 • 363 citations

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

1984 • 361 citations

Expression of Tac antigen on activated normal human B cells.

1984 • 355 citations

Factors Affecting B-Cell Growth and Differentiation

1985 • 354 citations

Studies on the capacity of B cells to serve as antigen-presenting cells.

1981 • 349 citations

Hydroxyurea: Differential Lethal Effects on Cultured Mammalian Cells during the Cell Cycle

1965 • 347 citations

Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2)

1985 • 343 citations

Fundamental immunology

1984 • 334 citations

Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues

1984 • 328 citations

B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation.

1984 • 324 citations

Protein A Isolated from Staphylococcus aureus after Digestion with Lysostaphin

1972 • 307 citations

Frequency of B lymphocytes responsive to anti-immunoglobulin.

1982 • 302 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

THE RELATIONSHIP BETWEEN ANTIGENIC STRUCTURE AND THE REQUIREMENT FOR THYMUS-DERIVED CELLS IN THE IMMUNE RESPONSE

1971 • 282 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?**Supported by U. S. Public Health Service Research Grant AI-08795-03 and American Cancer Society Research Grant E-395-D.

1971 • 276 citations

Lymphocyte stimulation by protein A of Staphylococcus aureus

1976 • 268 citations

Interleukin 1 is more than an interleukin

1982 • 257 citations

Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function.

1985 • 249 citations

Chapter 6 The Cell Cycle, Cell Lineages, and Cell Differentiation

1972 • 247 citations

T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.

1981 • 242 citations

Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody.

1983 • 241 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

The B cell surface molecule B1 is functionally linked with B cell activation and differentiation.

1985 • 232 citations

Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.

1981 • 232 citations

Thymus-independent antigens: complexity of B-lymphocyte activation revealed

1982 • 227 citations

Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells.

1985 • 216 citations

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

1977 • 212 citations

Expression of cell surface markers after human B lymphocyte activation.

1981 • 212 citations

Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

1978 • 211 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Role of γ-interferon in antibody-producing responses

1984 • 203 citations

B-cell stimulatory factor 1 activates resting B cells.

1985 • 201 citations

Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.

1982 • 201 citations

Monocyte Dependence of Pokeweed Mitogen-Induced Differentiation of Immunoglobulin-Secreting Cells from Human Peripheral Blood Mononuclear Cells

1979 • 197 citations

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

1986 • 194 citations

FORMATION OF MOUSE OR SHEEP REDBLOOD-CELL ROSETTES BY LYMPHOCYTES FROM NORMAL AND LEUKÆMIC INDIVIDUALS

1974 • 194 citations

Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes

1985 • 193 citations

T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.

1980 • 191 citations

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation.

1983 • 182 citations

Studies on immunological paralysis

1971 • 182 citations

Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation.

1983 • 181 citations

Lymphocytes in human immunodeficiency states: a study of membrane‐associated immunoglobulins

1971 • 181 citations

Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

1977 • 178 citations

Surface Immunoglobulin D as a Functional Receptor for a Subclass of B Lymphocytes

1977 • 173 citations

Role of the Bp35 cell surface polypeptide in human B-cell activation.

1985 • 173 citations

The Ontogeny of Thymic Independent Antibody Responses in Vitro in Normal Mice and Mice with an X-Linked B Cell Defect

1977 • 171 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

Polyclonal B-Cell Activators in the Study of the Regulation of Immunoglobulin Synthesis in the Human System

1982 • 162 citations

The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen.

1983 • 159 citations

Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes.

1984 • 156 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 156 citations

Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes.

1985 • 154 citations

Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin

1975 • 154 citations

The effects of interleukin 1 on human B cell activation and proliferation.

1983 • 151 citations

Binding of monoclonal antibody to the Epstein Barr virus (EBV)/CR2 receptor induces activation and differentiation of human B lymphocytes.

1985 • 150 citations

Activation of human B lymphocytes

1980 • 149 citations

AUTORADIOGRAPHIC STUDIES ON THE IMMUNE RESPONSE

1962 • 149 citations

Effect of IFN-γ on the immune response in vivo and on gene expression in vitro

1984 • 149 citations

Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2.

1984 • 143 citations

Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).

1982 • 142 citations

Frequency of antigen-sensitive cells to thymus-independent antigens

1971 • 140 citations

Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.

1984 • 136 citations

CELLULAR REQUIREMENTS FOR THE PRIMARY IN VITRO ANTIBODY RESPONSE TO DNP-FICOLL

1974 • 134 citations

Circulating and Mitogen-Induced Immunoglobulin-Secreting Cells in Human Peripheral Blood: Evaluation by a Modified Reverse Hemolytic Plaque Assay

1978 • 134 citations

Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.

1976 • 134 citations

In vitro immune response of human peripheral lymphocytes. I. The mechanism(s) involved in T cell helper functions in the pokeweed mitogen-induced differentiation and proliferation of B cells.

1977 • 133 citations

In vitro antigen-induced, antigen-specific antibody production in man. Specific and polyclonal components, kinetics, and cellular requirements.

1981 • 130 citations

T-independent responses in B cell-defective CBA/N mice toBrucella abortus and to trinitrophenyl (TNP) conjugates ofBrucella abortus

1978 • 129 citations

The Class of Surface Immunoglobulin on Virgin and Memory B Lymphocytes

1977 • 128 citations

B Lymphocyte: Activation by Insoluble Anti-Immunoglobulin: Induction of Immunoglobulin Secretion by a T Cell-Dependent Soluble Factor

1979 • 128 citations

Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors.

1979 • 126 citations

B Cell Growth and Differentiation Factors

1984 • 126 citations

Mechanism of the Suppressive Effect of Interferon on Antibody Synthesis in Vivo

1975 • 125 citations

CBA/N Immune Defective Mice; Evidence for the Failure of a B Cell Subpopulation to be Expressed

1982 • 121 citations

Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing Staphylococcus aureus.

1981 • 120 citations

B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth.

1985 • 118 citations

Differential expression of cell activation markers after stimulation of resting human B lymphocytes.

1984 • 118 citations

Mechanisms of T Cell-B Cell Interaction

1983 • 117 citations

Human B lymphoma cell line producing B cell growth factor.

1985 • 116 citations

Human B cell differentiation. II. Pokeweed mitogen-responsive B cells belong to a surface immunoglobulin D-negative subpopulation.

1982 • 114 citations

Studies of in vitro activation and differentiation of human B lymphocytes. I. Phenotypic and functional characterization of the B cell population responding to anti-Ig antibody.

1985 • 113 citations

H‐2‐unrestricted polyclonal maturation without replication of small B cells induced by antigen‐activated T cell help factors

1980 • 112 citations

Regulation of Growth and Proliferation in B Cell Subpopulations

1982 • 112 citations

MECHANISM OF ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE

1973 • 111 citations

The roles of interleukin 2 and interferon‐γ in human B cell activation, growth and differentiation

1986 • 111 citations

T Cell‐Derived Lymphokines That Induce IgM and IgG Secretion in Activated Murine B Cells

1984 • 109 citations

Characterization of human B cell growth factor (BCGF) from cloned T cells or mitogen-stimulated T cells.

1983 • 109 citations

Purification and characterization of fetal hematopoietic cells that express the common acute lymphoblastic leukemia antigen (CALLA).

1983 • 106 citations

Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.

1984 • 106 citations

Development of a human T-T cell hybridoma secreting B cell growth factor.

1983 • 104 citations

Macrophages and T cells control distinct phases of B cell differentiation in the humoral immune response in vitro.

1980 • 102 citations

Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes.

1981 • 101 citations

Soluble factors involved in B cell differentiation: identification of two distinct T cell-replacing factors (TRF).

1983 • 101 citations

B Cell Growth and Differentiation Factors and Mechanism of B Cell Activation

1984 • 99 citations

Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells.

1978 • 98 citations

Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice.

1972 • 98 citations

Enhancement of the Humoral Response of T Cell-Depleted Murine Spleens by a Factor Derived from Human Monocytes in Vitro

1974 • 94 citations

C_H Isotype 'Switching' During Normal B-Lymphocyte Development

1984 • 93 citations

Structural and functional characterization of IL 2 receptors on activated human B cells.

1985 • 92 citations

Interleukin 1 can act as a B-cell growth and differentiation factor.

1985 • 90 citations

Triggering mechanism of B lymphocytes. I. Effect of anti-immunoglobulin and enhancing soluble factor on differentiation and proliferation of B cells.

1975 • 90 citations

B cell heterogeneity—Difference in the size of B lymphocytes responding to T dependent and T independent antigens

1975 • 90 citations

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

1985 • 87 citations

Separable helper factors support B cell proliferation and maturation to Ig secretion.

1982 • 85 citations

The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man.

1983 • 85 citations

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.

1977 • 83 citations

Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition

1981 • 82 citations

Maturation of mitogen-activated bone marrow-derived lymphocytes in the absence of proliferation

1974 • 81 citations

Evidence for the identification of lymphocyte activating factor as the adherent cell-derived mediator responsible for enhanced antibody synthesis by nude mouse spleen cells

1978 • 80 citations

Sequential requirements for cell cycle progression of resting human B cells after activation by anti-Ig.

1984 • 80 citations

Maturational and functional diversity of human B lymphocytes delineated with anti-Leu-8.

1985 • 79 citations

COMPOSITION OF ORAL SOLUTIONS PREPARED BY JAMAICAN MOTHERS FOR TREATMENT OF DIARRHOEA

1981 • 79 citations

Thymus-Independence of Slowly Metabolized Immunogens

1972 • 78 citations

B cell helper factors. II. Synergy among three helper factors in the response of T cell- and macrophage-depleted B cells.

1982 • 78 citations

The Synergism of Aecessory Cells and of Soluble a‐Factors Derived from Them in the Activation of B Cells to Proliferation

1984 • 78 citations

Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody.

1985 • 77 citations

Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowan I-stimulated B cells.

1984 • 75 citations

ANTIGEN-REACTIVE CELLS IN NORMAL, IMMUNIZED, AND TOLERANT MICE

1969 • 75 citations

Size-dependent B lymphocyte subpopulations: relationship of cell volume to surface phenotype, cell cycle, proliferative response, and requirements for antibody production to TNP-Ficoll and TNP-BA.

1984 • 74 citations

Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets.

1986 • 73 citations

Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by human T cell leukemia virus (HTLV) and characterization of human BGDF (BCGF II).

1985 • 73 citations

Direct triggering of B lymphocytes by insolubilized antigen

1974 • 72 citations

Staphylococcal protein A, a T cell-regulated polyclonal activator of human B cells.

1980 • 72 citations

Activation of Human B Lymphocytes

1976 • 67 citations

Regulation of antibody response in vitro. IX. Induction of secondary anti-hapten IgG antibody response by anti-immunoglobulin and enhancing soluble factor.

1975 • 67 citations

T cell regulation of polyclonal B cell responsiveness. I. Helper effects of T cells.

1979 • 66 citations

B lymphocyte activation: Entry into cell cycle is accompanied by decreased expression of IgD but not IgM

1983 • 66 citations

Action of dextran sulfate as a direct and general B cell mitogen

1974 • 65 citations

In Vitro Immune Response of Human Peripheral Lymphocytes

1977 • 65 citations

Activation of antigen-specific B cells: role of T cells, cytokines, and antigen in induction of growth and differentiation.

1983 • 64 citations

Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.

1982 • 63 citations

Monoclonal antibodies to B cells

1983 • 62 citations

B cell growth factor and T cell growth factor produced by mitogen-stimulated normal human peripheral blood T lymphocytes are distinct molecules.

1982 • 62 citations

Loss of surface IgD by human B lymphocytes during polyclonal activation^*

1977 • 61 citations

Direct effects of a monoclonal B cell differentiation factor and of purified interleukin 1 on B cell differentiation.

1984 • 60 citations

B Cell Subsets and Differential Responses to Mitogens

1982 • 60 citations

Human B-lymphocyte subpopulations

1981 • 59 citations

T cell dependence and factor reconstitution of in vitro antibody responses to TNP-B. Abortus and TNP-Ficoll: restoration of depleted responses with chromatographed fractions of a T cell-derived factor.

1983 • 59 citations

Demonstration of the involvement of interleukin 2 in the differentiation of Staphylococcus aureus Cowan I-stimulated B cells.

1984 • 58 citations

Heterogeneity of B Cells: Direct Evidence of Selective Triggering of Distinct Subpopulations by Polyclonal Activators

1976 • 57 citations

Persistence of immunogenicity of two complex antigens retained in vivo.

1968 • 57 citations

Frequencies of the separate human B cell subsets activatable to Ig secretion by Epstein-Barr virus and pokeweed mitogen.

1983 • 56 citations

Surface Ig Isotypes on Cells Responding to Lipopolysaccharide by IgM and IgG Secretion

1979 • 56 citations

B lymphocyte differentiation induced by lipopolysaccharide. II. Response of fetal lymphocytes.

1975 • 56 citations

Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype.

1981 • 55 citations

The differentiation function of T cell‐replacing factor in nu/nu spleen cell cultures

1974 • 54 citations

Activation of human B lymphocytes. VIII. Differential radiosensitivity of subpopulations of lymphoid cells involved in the polyclonally-induced PFC responses of peripheral blood B lymphocytes.

1978 • 53 citations

From Antibody Structure to Immunological Diversification of Immune Response

1986 • 52 citations

Immunoglobulin Secretion by Human Splenic Lymphocytes in Vitro: The Effects of Antibodies to IgM and IgD

1978 • 52 citations

Human B lymphocyte subsets. I. IgG-bearing B cell response to pokeweed mitogen.

1981 • 52 citations

A requirement for nonspecific T cell factors in antibody responses to "T cell independent" antigens.

1983 • 52 citations

Induction and upregulation by interleukin 2 of high-affinity interleukin 2 receptors on thymocytes and T cells.

1985 • 51 citations

Direct effect of interleukin 2 on the differentiation of human B cells which have not been preactivated in vitro

1985 • 50 citations

Antigen-specific induction and regulation of antibody synthesis in cultures of human peripheral blood mononuclear cells.

1980 • 50 citations

Recruitment and Proliferation of Immunocompetent Cells during the Log Phase of the Primary Antibody Response

1969 • 49 citations

Regulation of human B-cell activation, proliferation, and differentiation by soluble factors

1984 • 49 citations

AUTORADIOGRAPHIC STUDIES ON THE PROLIFERATION OF ANTIBODY-PRODUCING CELLS IN VITRO

1974 • 48 citations

The Role of Receptor IgM and IgD in Determining Triggering and Induction of Tolerance in Murine B Cells¹

1979 • 48 citations

Triggering Mechanism of B Lymphocytes

1975 • 47 citations

In vitro generation of antigen-specific hemolytic plaque-forming cells from human peripheral blood mononuclear cells.

1981 • 44 citations

Recombinant interleukin 2 and gamma-interferon act synergistically on distinct steps of in vitro terminal human B cell maturation.

1986 • 44 citations

Selective activation of antigen-specific human B cells in recently immunized individuals by nonspecific factors in the absence of antigen.

1983 • 43 citations

Regulation of Antibody Response in Vitro

1975 • 43 citations

Obligatory role of gamma interferon in T cell-replacing factor-dependent, antigen-specific murine B cell responses.

1985 • 43 citations

Affinity-purified interleukin 2 induces proliferation of large but not small B cells.

1985 • 41 citations

Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes.

1983 • 41 citations

The roles of T cell factors in activation, cell cycle progression, and differentiation of human B cells.

1985 • 41 citations

Rosette formation with mouse erythrocytes defines a population of human B lymphocytes unresponsive to pokeweed mitogen.

1981 • 40 citations

T Cell Regulation of Polyclonal B Cell Responsiveness

1979 • 40 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide

1975 • 39 citations

The Activation of Murine B Cells: The Role of Surface Immunoglobulins

1980 • 39 citations

Isolation and functional analysis of human B cell populations. I. Characterization of the B1+B2+ and B1+B2- subsets.

1985 • 38 citations

Polyclonal activation of human peripheral blood B lymphocytes by formaldehyde-fixed Salmonella paratyphi B. I. Immunoglobulin production without DNA synthesis.

1981 • 37 citations

Regulation of the IgM and IgA anti-dextran B1355S response: synergy between IFN-gamma, BCGF II, and IL 2.

1985 • 37 citations

Human B cell differentiation. IV. Effect of monoclonal anti-immunoglobulin M and D antibodies on B cell proliferation and differentiation induced by T cell factors.

1983 • 36 citations

Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction.

1985 • 36 citations

Comparison of the expression of IL 2 receptors by human T and B cells: induction by the polyclonal mitogens, phorbol myristate acetate, and anti-mu antibody.

1985 • 36 citations

Implications for the role of cognate interactions in in vitro human B cell activation by Staphylococcus aureus Cowan I and pokeweed mitogen.

1986 • 36 citations

Interleukin 1 induces proliferation in two distinct B cell subpopulations responsive to two different murine B cell growth factors.

1984 • 35 citations

B cell growth factor activity of immunoaffinity‐purified and recombinant human interleukin 2

1985 • 33 citations

A cloned major histocompatibility complex-restricted trinitrophenyl-reactive human helper T cell line that activates B cell subsets via two distinct pathways.

1983 • 33 citations

Constitutive production by the WEHI-3 cell line of B cell growth and differentiation factor that co-purifies with interleukin 1.

1983 • 32 citations

Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.

1981 • 30 citations

Evidence that Pokeweed‐Mitogen‐reactive B Cells are Pre‐committed in Vivo to the High‐rate Secretion of a Single Immunoglobulin Isotype in Vitro

1981 • 30 citations

T Cell‐Dependent B Cell Activation

1984 • 30 citations

Studies on the Mechanism of Stimulation of the Humoral Response of Murine Spleen Cultures by Culture Fluids from Human Monocytes

1975 • 28 citations

Immune conservation: a possible consequence of the mechanism of interferon‐induced antibody suppression

1976 • 27 citations

Memory B cells at successive stages of differentiation: expression of surface IgD and capacity for self renewal

1980 • 24 citations

Klebsiella pneumoniae stimulate highly purified human blood B cells to mature into plaque forming cells without prior proliferation.

1983 • 24 citations

The role of monocyte factors in the differentiation of immunoglobulin secreting cells from human peripheral blood B cells.

1980 • 23 citations

The modulation of membrane Ia on human B lymphocytes

1985 • 22 citations

The ontogeny of B lymphocytes V. Lipopolysaccharide‐induced changes of IgD expression on murine B lymphocytes

1979 • 22 citations

Immunoglobulin isotype expression II. Frequency analysis in mitogen‐reactive B cells

1981 • 22 citations

Induction of high affinity IL 2 receptors on B cells responding to anti-Ig and T cell-derived helper factors.

1985 • 22 citations

Characterization of B cell subpopulations by velocity sedimentation, surface la antigens and immune function

1977 • 22 citations

Interleukin-2 does not induce murine B cells to secrete Ig.

1982 • 22 citations

Identification and characterization of a B cell activation factor (BCAF) produced by a human T cell line.

1986 • 20 citations

Regulation of B Cell Activation and Differentiation with Factors Generated by Human T Cell Hybridomas

1984 • 20 citations

Hydroxyurea and cell-cycle kinetics of cultured antibody-forming cells

1971 • 19 citations

Subpopulations of B lymphocytes: physical separation of functionally distinct stages of B-cell differentiation.

1976 • 19 citations

IgM‐ and IgD‐bearing peripheral blood lymphocytes differentiate to IgM but not IgG or IgA immunoglobulin‐secreting cells

1982 • 18 citations

The Role of Cell Membrane Immunoglobulin in Primate B Lymphocyte Differentiation

1979 • 17 citations

Immunoglobulin production in cultures of pokeweed mitogen stimulated human peripheral blood mononuclear cells requires interaction of interleukin 2 with the B cells

1986 • 16 citations

Role of Surface IgM and IgD in the Functional Differentiation of Human B Lymphocytes: Effect of Papain Treatment

1979 • 15 citations

Transferrin receptor induction is required for human B‐lymphocyte activation but not for immunoglobulin secretion

1985 • 15 citations

Response of human B cells to Staphylococcus aureus Cowan I: T-independent proliferation and T-dependent differentiation to immunoglobulin secretion involve subsets separable by rosetting with mouse erythrocytes.

1984 • 15 citations

Polyclonal B cell responses in the presence of defined filler cells: complementary effects of lipopolysaccharide and anti‐immunoglobulin antibodies

1984 • 13 citations

Human tonsil B lymphocyte function. I. The proliferative response to Staphylococcus aureus and pokeweed mitogen in relation to surface heavy chains mu and delta.

1984 • 11 citations

The requirement for esterase activation in T cell replacing factor (TRF)-induced IgG production in a human B blastoid cell line.

1982 • 10 citations

T cell activation of antigen-specific antibody responses by large B cells is MHC restricted.

1986 • 10 citations

Biochemical characterization and purification of human B cell stimulatory factor (BSF)

1985 • 9 citations

Synergy of helper factors in the differentiation of in vivo-preactivated antigen-specific human B cells

1985 • 9 citations

Lyb-5+ B cells can be activated by major histocompatibility complex-restricted as well as unrestricted activation pathways.

1985 • 8 citations

Interaction of helper T cells and Lyb5+ B cells responding to phosphorylcholine is MHC-restricted.

1984 • 8 citations

Human B-cell proliferation in response to recombinant interleukin 2 is not due to T-cell help

1985 • 8 citations

sIgD- and sIgD+ B cells responding to thymus-independent antigens have a different lymphokine requirement.

1985 • 8 citations

Effects of Staphylococcus aureus Cowan I bacteria on the immunoglobulin production from human B-cell subsets

1982 • 7 citations

The in vitro generation of antigen-binding cells

1980 • 6 citations

Proposed nomenclature for B-cell stimulating factors

1983 • 6 citations

The isotype cycle: Successive changes in surface immunoglobulin classes expressed by the antigen-binding B-cell population during the primary in vivo immune response

1981 • 5 citations

Non-specific factor enhancement of human in vitro antigen-dependent antibody synthesis: role of B cell activation and T cell help.

1984 • 4 citations

The simultaneous antagonistic effects of a T cell hybridoma product on the growth and the maturation of activated lymphocytes.

1983 • 3 citations

The role of complement receptor positive and complement receptor negative B cells in the primary and secondary immune response to thymus independent type 2 and thymus dependent antigens.

1985 • 2 citations

Two B-cell subpopulations identified by flow cytometry.

1985 • 1 citations