Cytokine mRNA expression in inflammatory multiple sclerosis lesions: Detection by non-radioactive in situ hybridization

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

1986 • 184 citations

Interleukin-6 is elevated in plasma in multiple sclerosis

1991 • 129 citations

Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis

1991 • 117 citations

Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.

1993 • 95 citations

In vitro study of mediators of inflammation in multiple sclerosis

1989 • 91 citations

Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis

1989 • 80 citations

Serum and CSF levels of IL‐2, sIL‐2R, TNF‐α, and IL‐1β in chronic progressive multiple sclerosis

1991 • 67 citations

Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation.

1992 • 66 citations

MACROPHAGE POPULATIONS ASSOCIATED WITH MULTIPLE SCLEROSIS PLAQUES

1987 • 63 citations

In situ hybridization histochemistry and the study of gene expression in the human brain

1990 • 62 citations

A longitudinal study on IL-2, sIL-2R, IL-4 and IFN-γ in multiple sclerosis CSF and serum

1991 • 57 citations

Glycosylation of interleukin‐6 purified from normal human blood mononuclear cells

1992 • 41 citations