IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

1995 • 357 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

Induction and regulation of IL-15 expression in murine macrophages.

1996 • 327 citations

Chemoattraction of human blood T lymphocytes by interleukin-15.

1995 • 303 citations

Interleukin-15: a novel anabolic cytokine for skeletal muscle.

1995 • 259 citations

Expression of the pX Gene of HTLV-I: General Splicing Mechanism in the HTLV Family

1985 • 201 citations

Structural comparisons among the short-chain helical cytokines

1994 • 161 citations

IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

1996 • 158 citations

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

1996 • 148 citations

A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes

1992 • 137 citations

Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.

1991 • 133 citations

Chromosomal assignment and genomic structure of Il15

1995 • 117 citations

Ultraviolet B radiation up-regulates the expression of IL-15 in human skin.

1995 • 104 citations

Multimeric cytokine receptors: common versus specific functions

1994 • 82 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Internal initiation of translation

1993 • 63 citations

Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently

1995 • 39 citations