Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Genomic and Biological Variation among Commonly Used Lymphocytic Choriomeningitis Virus Strains

1983 • 241 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection

1989 • 127 citations

Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus

1988 • 125 citations

Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus

1987 • 108 citations

Type 2 cytokines and negative immune regulation in human infections

1993 • 105 citations

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

1990 • 102 citations

Activation and differentiation requirements of primary T cells in vitro.

1993 • 102 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice.

1991 • 81 citations

Interleukin 2‐dependent activation of tumor‐specific cytotoxic T lymphocytes in vivo

1991 • 81 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma.

1995 • 52 citations

Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule

1992 • 49 citations

The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection.

1991 • 48 citations

The IL‐2 mediated amplification of cellular cytotoxicity

1991 • 38 citations

Molecular pathology of type 1 diabetes.

1990 • 38 citations

Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus.

1990 • 32 citations

Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions

1993 • 24 citations

Induction of competence to respond to IL-4 by CD4+ T helper type 1 cells requires costimulation.

1992 • 18 citations

IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice.

1994 • 15 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 15 citations

Generation and characterization of IL-2-activated veto cells.

1992 • 15 citations

Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. I. Differential helper cell requirement for the generation of cytotoxic effector cells from CD8+ precursor subpopulations.

1992 • 11 citations

IL-4-supported induction of cytolytic T lymphocytes requires IL-2 and IL-6

1991 • 10 citations

Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease

1992 • 9 citations

Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo

1991 • 6 citations

INDUCTION OF HLA-SPECIFIC CTL TO NONIMMUNOGENIC, HEAT-INACTIVATED LYMPHOCYTES BY INTERLEUKIN 2

1990 • 2 citations