Cytokine-regulated proteases in autoimmune diseases

Van Damme A.

1986 • 3,477 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

1992 • 365 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

1988 • 229 citations

The cognitive principle challenges clonal selection

1992 • 212 citations

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.

1993 • 196 citations

Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.

1993 • 196 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer

1992 • 160 citations

Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse

1992 • 156 citations

Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

1992 • 134 citations

T-cell recognition of myelin basic protein

1991 • 134 citations

Experimental Allergic Encephalomyelitis in the Rat: Response to Encephalitogenic Proteins and Peptides

1973 • 122 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis

1991 • 117 citations

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

1980 • 114 citations

Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.

1991 • 107 citations

Gamma-interferon: the match that lights the fire?

1988 • 102 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Production and regulation of gelatinase B by human T-cells

1993 • 80 citations

Cytokine Secretion by Multiple Sclerosis Monocytes

1992 • 79 citations

Immunology of multiple sclerosis.

1992 • 64 citations

ESTERASE, PEPTIDASE AND PROTEINASE ACTIVITIES OF HUMAN CEREBROSPINAL FLUID IN MULTIPLE SCLEROSIS

1968 • 51 citations

Contrasting effects of alpha, beta, and gamma interferons on nonspecific suppressor function in multiple sclerosis

1992 • 44 citations

Tumor Necrosis Factor‐Alpha and Interferon‐Gamma Synthesis by Cerebrospinal Fluid‐Derived T Cell Clones in Multiple Sclerosis

1992 • 29 citations

Hydrolysis of myelin basic protein in myelin membranes by granzymes of large granular lymphocytes.

1993 • 26 citations

Neutral protease in cerebrospinal fluid from patients with multiple sclerosis and other neurological diseases

1987 • 23 citations

A novel metalloproteinase originally isolated from brain myelin membranes is present in many tissues

1990 • 22 citations

Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. II. Immunologic evaluation

1991 • 10 citations