The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Interleukin 2

1984 • 497 citations

Thymoma production of T cell growth factor (Interleukin 2).

1980 • 487 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

1967 • 323 citations

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

1985 • 203 citations

High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61.

1985 • 203 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

Oncogenes, ions, and phospholipids

1985 • 171 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

Phorbol esters reduce gonadotrope responsiveness to protein kinase C activators but not to Ca2+-mobilizing secretagogues. Does protein kinase C mediate gonadotropin-releasing hormone action?

1987 • 110 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2

1987 • 83 citations

Distinction between antigen receptor and IL 2 receptor triggering events in the activation of alloreactive T cell clones with calcium ionophore and phorbol ester.

1985 • 73 citations

Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes.

1987 • 67 citations

Osmotic activation of the Na+H+ antiport in protein kinase C-depleted lymphocytes

1986 • 56 citations

Interleukin 2 rapidly stimulates synthesis and breakdown of polyphosphoinositides in interleukin 2-dependent, murine T-cell lines.

1987 • 43 citations

Production of immune interferon by an interleukin 2-independent murine T cell line.

1982 • 43 citations

Distinct signals are required for proliferation and lymphokine gene expression in murine T cell clones.

1986 • 41 citations

The protein kinase C inhibitor H-7, inhibits antigen and IL-2-induced proliferation of murine T cell lines

1987 • 39 citations

Molecular mechanisms involved in T cell activation. I. Evidence for independent signal-transducing pathways in lymphokine production vs proliferation in cloned cytotoxic T lymphocytes.

1987 • 29 citations

PMA alone induces proliferation of some murine T cell clones but not others.

1986 • 28 citations

The role of protein kinase C in early activation vs. growth of T lymphocytes

1988 • 24 citations

Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C.

1988 • 20 citations

Activation of the Na⁺/K⁺‐ATPase by interleukin‐2

1986 • 14 citations