Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes

1985 • 714 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.

1990 • 548 citations

Quantitative aspects of reactive gliosis: A review

1992 • 548 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Astrocyte‐specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein

1974 • 493 citations

Ameboid microglia as effectors of inflammation in the central nervous system

1987 • 477 citations

THE ASTROGLIAL RESPONSE TO STABBING. IMMUNOFLUORESCENCE STUDIES WITH ANTIBODIES TO ASTROCYTE‐SPECIFIC PROTEIN (GFA) IN MAMMALIAN AND SUBMAMMALIAN VERTEBRATES

1976 • 473 citations

Developmental and maturational changes in human blood lymphocyte subpopulations

1992 • 415 citations

Astrocytes Block Axonal Regeneration in Mammals by Activating the Physiological Stop Pathway

1987 • 400 citations

Fibrillary astrocytes proliferate in response to brain injury

1979 • 399 citations

Changing role of forebrain astrocytes during development, regenerative failure, and induced regeneration upon transplantation

1986 • 383 citations

Observations on the astrocyte response to a cerebral stab wound in adult rats

1985 • 354 citations

Deposition of Scar Tissue in the Central Nervous System

1983 • 285 citations

Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats

1988 • 279 citations

The proliferation of astrocytes around a needle wound in the rat brain.

1970 • 271 citations

Enhanced expression of transforming growth factor β1 in the rat brain after a localized cerebral injury

1992 • 220 citations

Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population

1988 • 220 citations

Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo.

1991 • 217 citations

Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life.

1983 • 184 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus

1993 • 180 citations

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1990 • 163 citations

Brain macrophages and microglia respond differently to lesions of the developing and adult visual system

1991 • 133 citations

Immunocytochemical staining for glial fibrillary acidic protein and the metabolism of cytoskeletal proteins in experimental allergic encephalomyelitis

1983 • 130 citations

Biochemical and immunocytochemical changes in glial fibrillary acidic protein after sab wounds

1990 • 126 citations

Human astrocytes proliferate in response to tumor necrosis factor alpha

1990 • 124 citations

Trauma‐induced proliferation of astrocytes in the brains of young and aged rats

1989 • 113 citations

The response of the cerebral hemisphere of the rat to injury. II. The neonatal rat

1990 • 112 citations

Detection of cytokine mRNA in astrocyte cultures using the polymerase chain reaction.

1990 • 112 citations

Autoradiographic Studies on Histogenesis of Brain Macrophages in the Mouse

1972 • 110 citations

Differences between adult and neonatal rats in their astroglial response to spinal injury

1984 • 110 citations

Cloning and expression of the cDNA for the murine interferon gamma receptor.

1989 • 103 citations

Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma.

1989 • 101 citations

Transient cortical astrogliosis induced by alcohol exposure during the neonatal brain growth spurt in rats

1993 • 98 citations

The response of the cerebral hemisphere of the rat to injury. I. The mature rat

1990 • 91 citations

An in vitro model of wound healing in the CNS: Analysis of cell reaction and interaction at different ages

1989 • 90 citations

Glial Fibrillary Acidic Protein Increases in the Spinal Cord of Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis

1988 • 90 citations

Differential proliferative response of human and mouse astrocytes to gamma‐interferon

1992 • 84 citations

The proliferative response of astrocytes to injury in neonatal rat brain. A combined immunocytochemical and autoradiographic study

1988 • 81 citations

Pathological reaction of astrocytes in perinatal brain injury

1986 • 79 citations

Preliminary studies of cytokine-induced functional effects on the visual pathways in the rabbit

1989 • 72 citations

Dissociation of GFAP intermediate filaments in eae: Observations in the lumbar spinal cord

1989 • 71 citations

Interferons and central regulation of feeding

1992 • 62 citations

Electron microscopic study of the reaction of the newborn rat brain to injury

1968 • 61 citations

Glial fibrillary acidic protein in chronic relapsing experimental allergic encephalomyelitis in SJL/J mice

1987 • 58 citations

Astrocytic reactivity and intermediate filament metabolism in experimental autoimmune encephalomyelitis: The effect of suppression with prazosin

1986 • 56 citations

Origin of contralateral reactive gliosis in surgically injured rat cerebral cortex

1991 • 53 citations

Separate blood and brain origins of proliferating cells during gliosis in adult brains

1990 • 50 citations

Immunofluorescence studies of the monocytes in the injured rat brain

1981 • 48 citations

Proliferation of human and mouse astrocytes in vitro: signalling through the protein kinase C pathway

1992 • 47 citations

Histological changes after transection of the spinal cord of fetal and neonatal mice

1979 • 46 citations

Changes in astroglial scar formation in rat optic nerve as a function of development

1990 • 36 citations

RESPONSE OF FETAL AND NEONATAL RAT BRAIN TO INJURY

1987 • 36 citations

The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain

1991 • 35 citations

Demonstration of the presence of a specific interferon-γ receptor on murine astrocyte cell surface

1991 • 31 citations

Neuritic growth maintained near the lesion site long after spinal cord transection in the newborn rat

1981 • 29 citations

The Age of Dependency of Enzymes in Reactive Glia.

1963 • 14 citations

Macrophage Ontogeny: Implications for Host Defence, T-lymphocyte Differentiation, and the Acquisition of Self-tolerance

1985 • 9 citations