Is interleukin 2 a neuromodulator in the brain?

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Is the Brain's Mind a Computer Program?

1990 • 606 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Interleukin 2

1984 • 497 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Short Papers

1977 • 360 citations

Interleukin 1: the first interleukin

1990 • 342 citations

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

1989 • 323 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

1986 • 251 citations

Evidence that locus coeruleus is the site where clonidine and drugs acting at α₁‐ and α₂‐adrenoceptors affect sleep and arousal mechanisms

1987 • 244 citations

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

1989 • 179 citations

Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor.

1985 • 164 citations

Circling behavior and stereotypy induced by intranigral opiate microinjections.

1977 • 156 citations

Transmembrane Ion Fluxes during Activation of Human T Lymphocytes: Role of Ca²⁺, Na⁺/H⁺ Exchange and Phospholipid Turnover

1987 • 154 citations

Behavioural and ECoG spectrum changes induced by intracerebral infusion of interferons and interleukin 2 in rats are antagonized by naloxone

1990 • 116 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Toxicity of interferon and interleukin

1987 • 111 citations

Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous system.

1986 • 104 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Interleukin 2 modulation of adenylate cyclase. Potential role of protein kinase C.

1986 • 93 citations

Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2

1987 • 83 citations

Macroglia: neural cells responsive to lymphokines and growth factors

1987 • 80 citations

Mechanism of pertussis toxin action on the adenylate cyclase system

1984 • 80 citations

In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain

1989 • 79 citations

In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain

1989 • 78 citations

Somnogenic activity of immune response modifiers

1990 • 67 citations

Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes.

1987 • 67 citations

Human recombinant interleukin-2 as an experimental therapeutic.

1990 • 66 citations

Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus

1988 • 65 citations

Potentiation of lymphokine-activated killer cell differentiation and lymphocyte proliferation by stimulation of protein kinase C or inhibition of adenylate cyclase.

1988 • 49 citations

Interferon modifies EEG and EEG-like activity recorded from sensory, motor, and limbic system structures in freely behaving rats.

1983 • 44 citations

Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates

1985 • 42 citations

Microinfusion of clonidine and yohimbine into locus coeruleus alters EEG power spectrum: effects of aging and reversal by phosphatidylserine

1988 • 40 citations

Interleukin-2

1990 • 35 citations

Alpha and Gamma Interferons' Effects on Cortical and Hippocampal Neurons: Microiontophoretic Application and Single Cell Recording

1984 • 30 citations

Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?

1988 • 19 citations

Visualization of cytokine and virus receptors common to the immune and central nervous system.

1987 • 17 citations

Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus

1989 • 17 citations

Ligand-specific calcium mobilization in IL 2 and IL 3 dependent cell lines.

1986 • 17 citations

Interleukin-2 stimulus-response coupling is calcium independent.

1987 • 12 citations