Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Regulation of ACTH Secretion: Variations on a Theme of B

1987 • 668 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Surgical Disconnection of the Medial Basal Hypothalamus and Pituitary Function in the Rhesus Monkey. I. Gonadotropin Secretion¹,²

1975 • 473 citations

The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1987 • 456 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

Immunoregulators in the nervous system

1991 • 380 citations

Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines.

1989 • 349 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Basal ACTH, Corticosterone and Corticosterone-Binding Globulin Levels over the Diurnal Cycle, and Age-Related Changes in Hippocampal Type I and Type II Corticosteroid Receptor Binding Capacity in Young and Aged, Handled and Nonhandled Rats

1992 • 200 citations

Immunoendocrine Communication via the Hypothalamo-Pituitary-Adrenal Axis in Autoimmune Diseases*

1993 • 196 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

RELATIONSHIP BETWEEN FOETAL CORTICOSTEROIDS, MATERNAL PROGESTERONE AND PARTURITION IN THE RAT

1977 • 184 citations

Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence

1993 • 182 citations

Chronic Administration of Corticotropin-Releasing Factor Increases Pituitary Corticotroph Number*

1987 • 178 citations

Immunosuppression by Glucocorticoids: Inhibition of Production of Multiple Lymphokines by in Vivo Administration of Dexamethasone

1993 • 173 citations

Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells.

1987 • 150 citations

Prostaglandin-Dependent in Vitro Stimulation of Adrenocortical Steroidogenesis by Interleukins*

1991 • 145 citations

Anterior pituitary hormone control by interleukin 2.

1991 • 134 citations

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

1991 • 111 citations

Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2

1993 • 107 citations

Interleukin-2 does not cross the blood-brain barrier by a saturable transport system

1994 • 86 citations

Interleukin-2 in cancer treatment: Disappointing or (still) promising? A review

1993 • 86 citations

Induction by Cytokines of the Pattern of Pituitary Hormone Secretion in Infection

1994 • 85 citations

Adoptive Immunotherapy for Cancer

1990 • 81 citations

Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus

1988 • 65 citations

Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration

1993 • 63 citations

Transient focal neurologic deficits complicating interleukin‐2 therapy

1990 • 59 citations

The interleukins-1α, -1β, and -2 do not acutely disrupt the murine blood - brain barrier

1992 • 59 citations

Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration.

1992 • 58 citations

Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cells

1989 • 58 citations

Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies.

1992 • 56 citations

Central Hypogonadism in Burned Men

1987 • 55 citations

Current status of Interleukin-2 therapy in cancer

1992 • 43 citations

Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids.

1992 • 42 citations

Appearance of cytokine-associated central nervous system myelin damage coincides temporally with serum tumor necrosis factor induction after recombinant interleukin-2 infusion in rats

1991 • 37 citations

Novel peptide pancreastatin: Its occurrence and codistribution with chromogranin a in the central nervous system of the pig

1989 • 29 citations

Cerebrovascular Effects and Tumor Kinetics after a Single Intratumoral Injection of Human Recombinant Interleukin-2 Alone or in Combination with Intravenous Chemotherapy in a Rat Model of Glioma

1992 • 21 citations

The rhythmic organization of the immune network: implications for the chronopharmacologic delivery of interferons, interleukins and cyclosporin

1992 • 9 citations