Evidence for a Critical Role for the Cytoplasmic Region of the Interleukin 2 (IL-2) Receptor γ Chain in IL-2, IL-4, and IL-7 Signalling

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

A new cytokine receptor superfamily

1990 • 506 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Cloning, sequence and expression of human interleukin-2 receptor

1984 • 272 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

1994 • 109 citations

Molecular Analysis of the Interleukin‐2 System

1986 • 89 citations

Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.

1992 • 83 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

1992 • 76 citations

An associated molecule, p64, eith high-affinity interleukin 2 receptor

1990 • 64 citations

Characterization of the heterodimeric complex of human IL-2 receptor alpha.beta chains reconstituted in a mouse fibroblast cell line, L929.

1990 • 51 citations

Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain.

1994 • 39 citations

Human interleukin 2 (IL 2) receptor β chain allows transduction of IL 2-induced proliferation signal(s) in a murine cell line

1989 • 27 citations

Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor γ

1993 • 15 citations

Signal transduction through the human IL-2 receptor β-chain expressed in IL-6- dependent mouse B cell hybridoma

1991 • 10 citations