Cytokine signal transduction

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

1991 • 372 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Functional domains of the granulocyte colony-stimulating factor receptor.

1991 • 342 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Cytokine receptors and signal transduction

1992 • 269 citations

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

1993 • 267 citations

Regulation of IgG1 and IgE Production by Interleukin 4

1988 • 244 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Stimulation of Hepatic Acute Phase Response by Cytokines and Glucocorticoids^a

1989 • 242 citations

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

1992 • 234 citations

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

1991 • 224 citations

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

1994 • 223 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6.

1993 • 192 citations

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

1990 • 177 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Leukemia inhibitory factor: A biological perspective

1991 • 167 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene.

1992 • 135 citations

Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils.

1989 • 133 citations

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.

1992 • 127 citations

Oncostatin M binds the high-affinity leukemia inhibitory factor receptor.

1992 • 117 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

Reconstitution of the functional receptors for murine and human interleukin 5.

1993 • 111 citations

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

1992 • 103 citations

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

1991 • 100 citations

Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.

1993 • 95 citations

Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.

1992 • 92 citations

c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

1992 • 76 citations

Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells.

1992 • 69 citations

Nuclear factors interacting with an interleukin-6 responsive element of rat α₂-macroglobulin gene

1989 • 68 citations

Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.

1992 • 66 citations

Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.

1989 • 48 citations

American Chemistry in Context: Chemistry and Modern Society . Historical Essays in Honor of Aaron J. Ihde. John Parascandola and James C. Whorton, Eds. American Chemical Society, Washington, D.C., 1983. xvi, 203 pp., $24.95. ACS Symposium Series, 228.

1984 • 12 citations

Critical cytoplasmic region of the IL-6 signal transducer gp130 is conserved in the cytokine receptor family

1993 • 8 citations