Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1982 • 877 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Hematopoietic regulators: redundancy or subtlety?

1993 • 473 citations

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

1990 • 436 citations

The interleukin 2 receptor. Functional consequences of its bimolecular structure.

1987 • 409 citations

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

1992 • 369 citations

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

1993 • 271 citations

Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.

1993 • 259 citations

Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis.

1990 • 222 citations

Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.

1990 • 219 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

Expression of a functional c-kit receptor on a subset of natural killer cells.

1993 • 143 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

Activation of natural killer cells via the p75 interleukin 2 receptor.

1989 • 133 citations

The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding.

1984 • 115 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

Expression and Ligand Binding Characterization of the .beta.-Subunit (p75) Ectodomain of the Interleukin-2 Receptor

1994 • 19 citations