Cytokines Regulate L‐Arginine‐Dependent Cyclic GMP Production in Rat Glial Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin

1990 • 474 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Synergism between tumor necrosis factor‐α and interferon‐γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide‐dependent mechanism

1992 • 290 citations

Astrocyte heterogeneity

1990 • 254 citations

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

1986 • 251 citations

The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids

1992 • 233 citations

Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha

1991 • 200 citations

Production of nitrite by neonatal rat microglial cells/ brain macrophages

1992 • 198 citations

Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide

1990 • 196 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone

1991 • 161 citations

Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.

1990 • 131 citations

Macrophage activation by interferon‐γ from host‐protective T cells is inhibited by interleukin (IL) 3 and IL 4 produced by disease‐promoting T cells in leishmaniasis

1989 • 130 citations

Interleukin 1β and tumour necrosis factor α induce a macrophage‐type of nitric oxide synthase in rat renal mesangial cells

1992 • 126 citations

L-Arginine-dependent production of nitrogen oxides by rat pulmonary macrophages

1991 • 123 citations

Is interleukin 2 a neuromodulator in the brain?

1991 • 111 citations

Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

1991 • 98 citations

Different receptors mediate stimulation of nitric oxide-dependent cyclic GMP formation in neurons and astrocytes in culture

1992 • 94 citations

Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α

1990 • 91 citations

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1992 • 91 citations

Biology and Pathology of Astrocyte-Neuron Interactions

1993 • 83 citations

Macroglia: neural cells responsive to lymphokines and growth factors

1987 • 80 citations

Interleukin-1β induction of tumor necrosis factor-alpha gene expression in human astroglioma cells

1992 • 77 citations

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß

1992 • 72 citations

Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line.

1992 • 71 citations

Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells

1991 • 58 citations

Spectrophotometric detection of nitrogen oxides using azo dyes

1992 • 52 citations

Astrocyte—Microglia Interactions

1993 • 51 citations

Nitric oxide synthase inhibitors inhibit interleukin-1 beta-induced depression of vascular smooth muscle.

1991 • 45 citations

Generation of Astrocyte Cultures from Normal and Neoplastic Central Nervous System

1990 • 40 citations

Central Nervous System Astroglial Cells Release Nitrogen Oxide(s) with Vasorelaxant Properties

1991 • 32 citations

Central Nervous System Astroglial Cells Release Nitrogen Oxide(s) with Vasorelaxant Properties

1991 • 22 citations

NADPH: A stimulatory cofactor for nitric oxide-induced ADP-ribosylation reaction

1992 • 15 citations

Escherichia-coli lipopolysaccharide enhances the release of a no-like factor from astrocytoma-cells in culture

1992 • 9 citations