Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Protein folding in the cell

1992 • 4,138 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

The Conversion of Testosterone to 5α-Androstan-17β-ol-3-one by Rat Prostate in Vivo and in Vitro

1968 • 1,023 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Female Steroid Hormones and Target Cell Nuclei

1974 • 946 citations

Nuclear localization of unoccupied oestrogen receptors

1984 • 882 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Estrogen-Receptor Interaction

1973 • 746 citations

CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

1991 • 733 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Steroid Receptors: Elements for Modulation of Eukaryotic Transcription

1976 • 688 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Tetratrico peptide repeat interactions: to TPR or not to TPR?

1995 • 624 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Glucocorticoid receptors: Relations between steroid binding and biological effects

1972 • 554 citations

Hormone Receptors: Studies on the Interaction of Estrogen with the Uterus

1968 • 537 citations

Selective Retention of Dihydrotestosterone by Prostatic Nuclei

1968 • 532 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Mapping of Glucocorticoid Receptor Immunoreactive Neurons in the Rat Tel- and Diencephalon Using a Monoclonal Antibody against Rat Liver Glucocorticoid Receptor*

1985 • 512 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis

1990 • 507 citations

Immunohistochemical Localization of the Androgen Receptor in Rat and Human Tissues*

1990 • 492 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.

1992 • 486 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

Receptor Proteins for Androgens

1969 • 452 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

1987 • 409 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

The Intranuclear Binding of Testosterone and 5α-Androstan-17β-ol-3-one by Rat Prostate

1968 • 401 citations

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

1979 • 401 citations

Relation of steroid structure to enzyme induction in hepatoma tissue culture cells

1970 • 399 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones

1994 • 382 citations

Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro

1968 • 381 citations

Progesterone-binding Components of Chick Oviduct

1972 • 372 citations

Purification of the major mammalian heat shock proteins.

1982 • 369 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Molybdate inhibition of glucocorticoid receptor inactivation and transformation.

1979 • 339 citations

Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.

1986 • 338 citations

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

1992 • 335 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Glucocorticoid-binding Proteins of Rat Liver Cytosol

1972 • 328 citations

Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells

1971 • 328 citations

Activation, Transformation, and Subunit Structure of Steroid Hormone Receptors

1982 • 323 citations

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.

1996 • 322 citations

Progesterone-binding Components of Chick Oviduct

1970 • 321 citations

Immunocytochemical Study of Mammalian Progesterone Receptor Using Monoclonal Antibodies*

1985 • 319 citations

Antibodies to two major chicken heat shock proteins cross-react with similar proteins in widely divergent species.

1982 • 316 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1996 • 309 citations

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1994 • 308 citations

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Aluminofluoride and beryllofluoride complexes: new phosphate analogs in enzymology

1990 • 307 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

Prolyl Isomerase: Enzymatic Catalysis of Slow Protein-Folding Reactions

1993 • 307 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Genetic Mechanisms Controlling the Induction of Polysubstrate Monooxygenase (P-450) Activities

1981 • 296 citations

Nucleocytoplasmic shuttling of the progesterone receptor.

1991 • 296 citations

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila

1994 • 294 citations

A SOLUBLE ANDROGEN RECEPTOR IN THE CYTOPLASM OF RAT PROSTATE

1969 • 293 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

1994 • 293 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent

1995 • 291 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

1992 • 284 citations

Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein.

1991 • 284 citations

Estrogen Receptors in the Rat Uterus

1969 • 282 citations

ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF RNA SYNTHESIS

1964 • 279 citations

Nuclear import of the human androgen receptor

1993 • 277 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

Stereospecific binding of estrogens in the rat uterus

1965 • 272 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 • 267 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

1993 • 266 citations

ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS

1963 • 265 citations

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

1994 • 261 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Acidophilic activation of steroid hormone receptors

1973 • 260 citations

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

1996 • 259 citations

Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis.

1978 • 258 citations

Early Events in Glucocorticoid Action

1973 • 257 citations

Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.

1990 • 257 citations

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1994 • 257 citations

Inhibition of progesterone receptor activation by sodium molybdate

1980 • 257 citations

HIGH RESOLUTION AUTORADIOGRAPHY WITH DRY MOUNTED, FREEZE-DRIED FROZEN SECTIONS COMPARATIVE STUDY OF SIX METHODS USING TWO DIFFUSIBLE COMPOUNDS H-ESTRADIOL AND H-MESOBILIRUBINOGEN

1966 • 256 citations

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

1992 • 252 citations

Estrogen-binding substances of target tissues

1969 • 251 citations

Role of DNA and Specific Cytoplasmic Receptors in Glucocorticoid Action

1972 • 248 citations

Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae.

1989 • 248 citations

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein.

1981 • 246 citations

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.

1993 • 246 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Phosphorylation of Steroid Hormone Receptors*

1992 • 243 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.

1989 • 241 citations

Purification of the glucocorticoid receptor from rat liver cytosol.

1979 • 239 citations

The origin of the eukaryotic cell.

1996 • 238 citations

Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies.

1984 • 237 citations

Role of the Protein Chaperone YDJ1 in Establishing Hsp90-Mediated Signal Transduction Pathways

1995 • 237 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation.

1986 • 233 citations

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.

1994 • 231 citations

Steroid receptors and their associated proteins

1993 • 231 citations

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

1990 • 229 citations

A receptor molecule for estrogens: studies using a cell-free system.

1967 • 229 citations

Steroid Hormone Regulation of Gene Expression

1985 • 228 citations

The dynamic state of heat shock proteins in chicken embryo fibroblasts.

1986 • 227 citations

Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines.

1980 • 227 citations

The Tetratricopeptide Repeat Domain of Protein Phosphatase 5 Mediates Binding to Glucocorticoid Receptor Heterocomplexes and Acts as a Dominant Negative Mutant

1996 • 224 citations

Binding of p23 and hsp90 during assembly with the progesterone receptor.

1995 • 224 citations

Activation of the glucocorticoid-receptor complex

1982 • 224 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells

1973 • 221 citations

Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes.

1990 • 221 citations

The "activated" hepatic glucocorticoid-receptor complex. Its generation and properties.

1975 • 213 citations

Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70.

1996 • 212 citations

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli.

1987 • 211 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

Glucocorticoid-binding Proteins of Rat Liver Cytosol

1972 • 206 citations

Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells

1972 • 206 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

The origin of the eukaryotic cell

1996 • 204 citations

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

1997 • 202 citations

Hold 'em and Fold 'em: Chaperones and Signal Transduction

1995 • 201 citations

Isolation of Hsp90 mutants by screening for decreased steroid receptor function.

1993 • 201 citations

Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells.

1983 • 200 citations

The Molecular Mechanism of the in Vitro 4 S to 5 S Transformation of the Uterine Estrogen Receptor

1974 • 199 citations

Structure, dissociation, and proteolysis of mammalian steroid receptors. Multiplicity of glucocorticoid receptor forms and proteolytic enzymes in rat liver and kidney cytosols.

1983 • 197 citations

Molecular Cloning of Human FKBP51 and Comparisons of Immunophilin Interactions with Hsp90 and Progesterone Receptor

1997 • 197 citations

The Chicken Progesterone Receptor A and B Isoforms Are Products of an Alternate Translation Initiation Event

1989 • 196 citations

Glucocorticoid receptor inactivation under cell-free conditions.

1977 • 196 citations

Binding of heat shock proteins to the avian progesterone receptor.

1989 • 192 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)

1993 • 192 citations

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.

1994 • 190 citations

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

1990 • 190 citations

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1990 • 189 citations

Structure of Mammalian Steroid Receptors: Evolving Concepts and Methodological Developments

1984 • 188 citations

Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species

1985 • 188 citations

Transformation of glucocorticoid and progesterone receptors to the DNA‐binding state

1987 • 187 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Polypeptide components of two 8 S forms of chicken oviduct progesterone receptor.

1984 • 186 citations

Characterization of the purified activated glucocorticoid receptor from rat liver cytosol.

1984 • 186 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation.

1986 • 184 citations

Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery

1997 • 183 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

A prostatic cytosol receptor

1970 • 179 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains.

1982 • 178 citations

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

1992 • 177 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family

1987 • 176 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Cyclophilin 40 (CyP-40), Mapping of Its hsp90 Binding Domain and Evidence That FKBP52 Competes with CyP-40 for hsp90 Binding

1996 • 174 citations

Progesterone-binding Protein of Chick Oviduct

1972 • 173 citations

Nuclear uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Role of the hepatic cytosol receptor protein.

1979 • 173 citations

Fkbp51, a Novel T-Cell-Specific Immunophilin Capable of Calcineurin Inhibition

1995 • 173 citations

Antipeptide Antibodies to Two Distinct Regions of the Androgen Receptor Localize the Receptor Protein to the Nuclei of Target Cells in the Rat and Human Prostate*

1990 • 173 citations

Positive cooperativity of the estrogen receptor.

1981 • 173 citations

The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor

1995 • 172 citations

Activation of thymocyte glucocorticoid receptors to the steroid binding form. The roles of reduction agents, ATP, and heat-stable factors.

1979 • 171 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Evidence that dephosphorylation inactivates glucocorticoid receptors.

1977 • 170 citations

A reconstituted cell-free system for the specific transfer of steroid–receptor complexes into nuclear chromatin isolated from rat ventral prostate gland

1971 • 170 citations

A steroid-inducible gene expression system for plant cells.

1991 • 169 citations

Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.

1994 • 169 citations

An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.

1992 • 168 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Bidirectional transport of glucocorticoid receptors across the nuclear envelope.

1993 • 167 citations

Receptors from Glucocorticoid-Sensitive Lymphoma Cells and Two Classes of Insensitive Clones: Physical and DNA-Binding Properties

1974 • 166 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition

1991 • 165 citations

Transit of pp60v-src to the plasma membrane.

1982 • 165 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Progesterone receptor in the chick oviduct: an immunohistochemical study with antibodies to distinct receptor components.

1984 • 164 citations

Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state.

1991 • 163 citations

A Model of Protein Targeting Mediated by Immunophilins and Other Proteins That Bind to hsp90 via Tetratricopeptide Repeat Domains

1996 • 163 citations

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

1983 • 162 citations

Characterization of nonactivated and activated glucocorticoid-receptor complexes from intact rat thymus cells.

1983 • 162 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

Selective accumulation of tritium-labelled hexoestrol by the reproductive organs of immature female goats and sheep

1959 • 162 citations

The Carboxy-Terminal Region of Mammalian HSP90 Is Required for Its Dimerization and Function In Vivo

1994 • 161 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.

1995 • 161 citations

Reconstitution of the Steroid Receptor·hsp90 Heterocomplex Assembly System of Rabbit Reticulocyte Lysate

1996 • 160 citations

Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1.

1992 • 160 citations

Estrogen-binding proteins of calf uterus. Interrelationship between various forms and identification of a receptor-transforming factor

1972 • 159 citations

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1985 • 158 citations

Characterization of two forms of glucocorticoid hormone-receptor complex separated by DEAE-cellulose column chromatography

1977 • 158 citations

Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae.

1994 • 158 citations

Cooperative Action of Hsp70, Hsp90, and DnaJ Proteins in Protein Renaturation

1996 • 157 citations

Progesterone in uterus and plasma. IV — Progesterone receptor(s) in guinea pig uterus cytosol

1970 • 157 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein.

1985 • 156 citations

Steroid-binding properties and stabilization of cytoplasmic glucocorticoid receptors from rat thymus cells

1973 • 155 citations

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain.

1994 • 155 citations

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

1992 • 155 citations

Effects of Molybdate and Endogenous Inhibitors on Steroid-Receptor Inactivation, Transformation, and Translocation

1984 • 153 citations

Activation of steroid hormone–receptor complexes in intact target cells in physiological conditions

1979 • 152 citations

Sulfhydryl Groups and Estradiol-Receptor Interaction

1967 • 151 citations

Progesterone binding components of chick oviduct. X. Purification by affinity chromatography

1975 • 151 citations

The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system.

1994 • 151 citations

Subunit dissociation as a possible mechanism of glucocorticoid receptor activation

1983 • 150 citations

The glucocorticoid receptor in GH1 cells. Evidence from dense amino acid labeling and whole cell studies for an equilibrium model explaining the influence of hormone on the intracellular distribution of receptor.

1983 • 150 citations

Progesterone-binding Components of Chick Oviduct

1971 • 149 citations

Reconstitution of Progesterone Receptor with Heat Shock Proteins

1990 • 149 citations

Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor.

1994 • 149 citations

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1991 • 147 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

In Vitro Conversion of Estradiol-Receptor Protein to Its Nuclear Form: Dependence on Hormone and DNA

1972 • 145 citations

On the Specificity of the Binding of the Estradiol Receptor Protein to Deoxyribonucleic Acid

1974 • 144 citations

Properties of a uterine oestradiol receptor

1968 • 144 citations

Progesterone-binding components of chick oviduct. VIII. Receptor activation and hormone-dependent binding to purified nuclei.

1975 • 144 citations

Mapping the HSP90 binding region of the glucocorticoid receptor.

1990 • 144 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

Remodeling the estrogen receptor model

1984 • 142 citations

Testosterone Cytosol “Receptor” in the Rat Levator Ani Muscle

1972 • 142 citations

Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro

1989 • 140 citations

Tissue-specific stimulation of RNA synthesis by transformed estradiol-receptor complex

1972 • 140 citations

ATP-dependent activation of L cell glucocorticoid receptors to the steroid binding form.

1979 • 140 citations

The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein.

1987 • 139 citations

Phosphorylation in vivo of chicken oviduct progesterone receptor.

1982 • 138 citations

Hormone-dependent Transactivation by the Human Androgen Receptor Is Regulated by a dnaJ Protein

1995 • 137 citations

Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin.

1993 • 137 citations

Hormone-induced dissociation of the androgen receptor-heat-shock protein complex: use of a new monoclonal antibody to distinguish transformed from nontransformed receptors

1992 • 136 citations

Rapamycin and FK506 binding proteins (immunophilins)

1991 • 136 citations

A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.

1994 • 134 citations

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

1993 • 133 citations

Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.

1994 • 132 citations

Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus.

1995 • 131 citations

Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype

1992 • 131 citations

Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. A possible steroid receptor for growth inhibition.

1970 • 131 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Activation of the rat liver glucocorticoid-receptor complex

1977 • 130 citations

The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

1987 • 130 citations

Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization

1993 • 128 citations

Progesterone “Receptor” in Rabbit Uterus.

1973 • 127 citations

Glucocorticoid Receptors and the Role of Glucocorticoids in Fetal Lung Development

1972 • 126 citations

Isolation and characterization of a 40-kDa cyclophilin-related protein.

1992 • 125 citations

An FK506-sensitive Transporter Selectively Decreases Intracellular Levels and Potency of Steroid Hormones

1996 • 125 citations

Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate.

1987 • 125 citations

In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus.

1994 • 125 citations

Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts

1990 • 124 citations

Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.

1988 • 124 citations

Cell cycle regulation of glucocorticoid receptor function.

1992 • 124 citations

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor.

1988 • 123 citations

Evidence that the 90-Kilodalton Heat Shock Protein is Associated with Tubulin-Containing Complexes in L Cell Cytosol and in Intact PtK Cells

1988 • 122 citations

The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90

1995 • 122 citations

Inhibition of uterine estrogen receptor transformation by sodium molybdate.

1980 • 121 citations

Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors.

1988 • 121 citations

Domain structure of the glucocorticoid receptor protein.

1987 • 121 citations

Interaction of glucocorticoids with rat liver nuclei. I. Role of the cytosol proteins

1973 • 120 citations

Relationships between renal cytoplasmic and nuclear aldosterone-receptors

1972 • 120 citations

Distinct Roles of the Molecular Chaperone hsp90 in Modulating Dioxin Receptor Function via the Basic Helix-Loop-Helix and PAS Domains

1995 • 118 citations

Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.

1990 • 118 citations

Heat Shock Protein 84 Forms a Complex with Mutant p53 Protein Predominantly within a Cytoplasmic Compartment of the Cell

1996 • 117 citations

Estrogen receptor in the rat uterus. Physiological forms and artifacts

1972 • 117 citations

Interaction between casein kinase II and the 90-kDa stress protein, HSP90

1995 • 117 citations

Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis.

1993 • 116 citations

Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins.

1982 • 116 citations

Effects of calf intestinal alkaline phosphatase, phosphatase inhibitors, and phosphorylated compounds on the rate of activation of glucocorticoid-receptor complexes

1980 • 115 citations

Isoform composition and stoichiometry of the approximately 90-kDa heat shock protein associated with glucocorticoid receptors.

1988 • 114 citations

Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.

1994 • 114 citations

Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

1992 • 113 citations

A low molecular weight inhibitor of steroid receptor activation.

1977 • 113 citations

Stereospecific Binding of Aldosterone to Renal Chromatin

1970 • 113 citations

Purification and characterization of the chick oviduct progesterone receptor a subunit

1979 • 113 citations

Subunit composition of the molybdate-stabilized “8-9 S” nontransformed estradiol receptor purified from calf uterus.

1987 • 112 citations

In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90.

1990 • 112 citations

Regulation of protein function through expression of chimaeric proteins

1994 • 111 citations

Effect of Molybdate on Activation and Stabilization of Steroid Receptors*

1980 • 111 citations

Involvement of a low molecular weight component(s) in the mechanism of action of the glucocorticoid receptor

1976 • 110 citations

Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription

1990 • 110 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein.

1996 • 108 citations

Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model.

1984 • 108 citations

Two FKBP-related proteins are associated with progesterone receptor complexes.

1993 • 106 citations

Ultrastructural localization of the progesterone receptor by an immunogold method: effect of hormone administration.

1986 • 106 citations

Cytoplasmic anchoring proteins and the control of nuclear localization

1989 • 106 citations

Metabolism and Protein Binding of Sex Steroids in Target Organs: An Approach to the Mechanism of Hormone Action

1971 • 106 citations

Inactivation of glucocorticoid-binding capacity by protein phosphatases in the presence of molybdate and complete reactivation of dithiothreitol.

1982 • 106 citations

Characterization of the 4 S and 5 S Forms of the Estradiol Receptor Protein and Their Interaction with Deoxyribonucleic Acid

1974 • 103 citations

Soluble Complexes between Steroid Hormones and Target-Tissue Receptors Bind Specifically to Target-Tissue Chromatin

1971 • 103 citations

Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies

1985 • 103 citations

The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor

1990 • 103 citations

‘Activation-labile’ glucocorticoid–receptor complexes of a steroid-resistant variant of CEM-C7 human lymphoid cells

1980 • 103 citations

All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a “foldosome”.

1994 • 102 citations

Differential regulation of Hsp70 subfamilies by the eukaryotic DnaJ homologue YDJ1

1994 • 101 citations

Monovalent cation selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90.

1992 • 101 citations

A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.

1991 • 101 citations

Control of steroid receptor function and cytoplasmic‐nuclear transport by heat shock proteins

1992 • 100 citations

Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90

1991 • 100 citations

Steady-state level of the specific glucocorticoid binding component in mouse fibroblasts

1972 • 100 citations

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

1989 • 100 citations

Specificity and thermodynamic properties of the corticosteroid binding to a receptor of rat thymocytes in vitro

1968 • 100 citations

Immunocytology with microwave-fixed fibroblasts shows 1 alpha,25-dihydroxyvitamin D3-dependent rapid and estrogen-dependent slow reorganization of vitamin D receptors.

1990 • 99 citations

Assessment of the ATP Binding Properties of Hsp90

1996 • 98 citations

The Role of Sulfhydryl Groups in the Binding of Glucocorticoids by Cytoplasmic Receptors of Lung and Other Mammalian Tissues¹

1977 • 97 citations

The calmodulin-binding domain of the mouse 90-kDa heat shock protein

1993 • 97 citations

Intracellular traffic of steroid hormone receptors

1996 • 96 citations

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

1995 • 96 citations

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

1991 • 95 citations

Overexpression and characterization of the human mineralocorticoid receptor.

1991 • 95 citations

Glucocorticoid receptors lacking hormone-binding activity are bound in nuclei of ATP-depleted cells

1986 • 95 citations

Cloning of a cDNA for Heat-Shock Protein hsp40, a Human Homolog of Bacterial DnaJ

1993 • 95 citations

Mineralocorticosteroid Receptor of the chick intestine

1989 • 94 citations

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.

1994 • 94 citations

Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.

1992 • 93 citations

Progesterone-binding components of chick oviduct. Receptor B subunit protein purified to apparent homogeneity from laying hen oviducts.

1977 • 93 citations

Activation and changes in sedimentation properties of steroid receptors.

1980 • 93 citations

The involvement of receptor sulphydryl groups in the binding of steroids to the cytoplasmic glucocorticoid receptor from rat thymus

1975 • 93 citations

Resolution of activated and unactivated forms of the glucocorticoid receptor from rat liver

1977 • 93 citations

Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

1994 • 93 citations

Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression.

1992 • 93 citations

Age-Dependent Association of Isolated Bovine Lens Multicatalytic Proteinase Complex (Proteasome) with Heat-Shock Protein 90, an Endogenous Inhibitor

1995 • 92 citations

Reversible disaggregation of the cytosol-estrogen binding protein of uterine cytosol.

1968 • 92 citations

Possible Involvement of the 90-kDa Heat Shock Protein in the Regulation of Protein Synthesis

1989 • 92 citations

Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90

1991 • 91 citations

Requirement for activation in the binding of progesterone receptor to ATP-sepharose

1978 • 91 citations

Activation of liver and kidney glucocorticoid-receptor complexes occurs in vivo

1980 • 91 citations

Purification of "nontransformed" avian progesterone receptor and preliminary characterization.

1982 • 90 citations

Cytoplasmic 8 S glucocorticoid receptor binds to actin filaments through the 90-kDa heat shock protein moiety

1991 • 90 citations

Purification of the unactivated glucocorticoid receptor and its subsequent in vitro activation.

1984 • 89 citations

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

1992 • 89 citations

Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.

1983 • 88 citations

Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking.

1996 • 88 citations

Purification of Two Dexamethasone-Binding Proteins from Rat-Liver Cytosol

1978 • 88 citations

Structural and functional aspects of basic helix-loop-helix protein folding by heat-shock protein 90.

1994 • 88 citations

Nature of Oestrogen Specific Binding Sites in the Nuclei of Mouse Uteri

1971 • 88 citations

Evidence for the Association of the Heme-regulated eIF-2α Kinase with the 90-kDa Heat Shock Protein in Rabbit Reticulocyte Lysate in Situ

1989 • 87 citations

A kinetic analysis of the estrogen receptor transformation.

1975 • 86 citations

Expression of active hormone and DNA-binding domains of the chicken progesterone receptor in E. coli.

1989 • 86 citations

Glucocorticoid receptor phosphorylation, transformation, and DNA binding.

1987 • 86 citations

Limited proteolysis of covalently labeled glucocorticoid receptors as a probe of receptor structure

1984 • 85 citations

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1992 • 85 citations

Nucleocytoplasmic Shuttling of Steroid Receptors

1995 • 85 citations

Progesterone Receptor from Chick Oviduct:. Purification of Molybdate-Stabilized Form and Preliminary Characterization

1982 • 85 citations

v-mosOncoproteins Affect the Nuclear Retention and Reutilization of Glucocorticoid Receptors

1989 • 85 citations

Regulation of glucocorticoid receptor protein and mRNA levels.

1989 • 84 citations

Evolution of a Model of Estrogen Action

1986 • 84 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

Estrogen-dependent alterations in differentiation state of myeloid cells caused by a v-myb/estrogen receptor fusion protein.

1991 • 83 citations

Interaction of glucocorticoids with rat liver nuclei. II. Nature of the cytosol transfer factor and the nuclear acceptor site

1973 • 83 citations

Glucocorticoid receptor activation and inactivation in cultured human lymphocytes.

1981 • 83 citations

Structural Organization of Procaryotic and Eucaryotic Hsp90. INFLUENCE OF DIVALENT CATIONS ON STRUCTURE AND FUNCTION

1995 • 83 citations

Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.

1991 • 83 citations

Polypeptide Interactions with Molecular Chaperones and their Relationship to In Vivo Protein Folding

1994 • 83 citations

In situ distinction between steroid receptor binding and transactivation at a target gene.

1991 • 82 citations

The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor.

1994 • 82 citations

Inactivation of mammary cytoplasmic glucocorticoid receptors under cell-free conditions.

1980 • 82 citations

A role for Hsp90 in retinoid receptor signal transduction.

1995 • 82 citations

Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59

1990 • 81 citations

Stabilization of the avian progesterone receptor by inhibitors

1979 • 81 citations

Molybdate-stabilized glucocorticoid receptor: evidence for a receptor heteromer

1985 • 81 citations

The interaction of uterine estrogen receptors with DNA

1972 • 81 citations

Estrogen-independent activation of the receptor protein of calf uterine cytosol

1972 • 80 citations

Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein

1992 • 80 citations

Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.

1994 • 80 citations

Binding of Immunophilins to the 90 kDa Heat Shock Protein (hsp90) via a Tetratricopeptide Repeat Domain Is a Conserved Protein Interaction in Plants

1996 • 79 citations

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

1996 • 79 citations

Stoichiometric analysis of the specific interaction of the glucocorticoid receptor with DNA.

1986 • 79 citations

The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors.

1987 • 79 citations

Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex

1990 • 78 citations

Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex

1994 • 78 citations

FK506 binding to the 56-kilodalton immunophilin (hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function

1993 • 78 citations

The kinetics of glucocorticoid binding to the soluble specific binding protein of mouse fibroblasts.

1975 • 77 citations

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

1992 • 77 citations

Steroid-binding domains for regulating the functions of heterologous proteins in cis

1993 • 77 citations

Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors

1987 • 77 citations

Effect of Geldanamycin on the Kinetics of Chaperone-Mediated Renaturation of Firefly Luciferase in Rabbit Reticulocyte Lysate

1996 • 77 citations

Inactivation of glucocorticoid receptors in cell-free preparations of rat liver.

1977 • 77 citations

Investigations on the glucocorticoid-binding protein from rat thymocytes

1972 • 77 citations

The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:

1995 • 76 citations

A new procedure for the quantitation of nuclear and cytoplasmic androgen receptors.

1981 • 75 citations

Mechanism of Activation of Steroid Receptors: Involvement of Low Molecular Weight Inhibitor in Activation of Androgen, Glucocorticoid, and Estrogen Receptor Systems*

1980 • 75 citations

Steroid Binding Activity Is Retained in a 16-kDa Fragment of the Steroid Binding Domain of Rat Glucocorticoid Receptors

1989 • 75 citations

Chromatographic separation on phosphocellulose of activated and nonactivated forms of steroid-receptor complex. Purification of the activated complex

1976 • 75 citations

Structurally based, selective interaction of arsenite with steroid receptors.

1990 • 75 citations

Overexpression of p59-HBI (FKBP59), Full Length and Domains, and Characterization of PPlase Activity

1993 • 75 citations

Differential intracellular localization of human mineralocorticosteroid receptor on binding of agonists and antagonists

1994 • 74 citations

Evidence for reversible, non-microtubule and non-microfilament-dependent nuclear translocation of hsp90 after heat shock in human fibroblasts.

1992 • 74 citations

Oligomeric structure of molybdate-stabilized, nontransformed 8S progesterone receptor from chicken oviduct cytosol

1984 • 74 citations

Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton.

1996 • 74 citations

Interaction of the glucocorticoid receptor with the Mr 90,000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation.

1989 • 74 citations

Animal and Plant Cell Lysates Share a Conserved Chaperone System That Assembles the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90

1996 • 74 citations

Photoaffinity labeling and partial proteolysis of wild-type and variant glucocorticoid receptors

1983 • 74 citations

Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae.

1992 • 73 citations

Purification and characterization of an endogenous inhibitor specific to the Z‐Leu‐Leu‐Leu‐MCA degrading activity in proteasome and its identification as heat‐shock protein 90

1994 • 73 citations

FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts.

1993 • 72 citations

“Non-activated” form of the progesterone receptor from chick oviduct: Characterization

1980 • 72 citations

The 90 kDa heat-shock protein (hsp90) modulates the binding of the oestrogen receptor to its cognate DNA

1996 • 72 citations

Demonstration by Confocal Microscopy that Unliganded Overexpressed Glucocorticoid Receptors are Distributed in a Nonrandom Manner throughout All Planes of the Nucleus

1991 • 72 citations

Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.

1992 • 71 citations

Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptors.

1993 • 71 citations

Heteromeric nature of glucocorticoid receptor

1985 • 71 citations

Hormone-receptor interaction as a guide to biochemical mechanism.

1971 • 71 citations

Effect of sodium molybdate on cytosolic androgen receptors in rat prostate

1980 • 70 citations

A 50 Kilodalton Protein Associated with Raf and pp60^v-src Protein Kinases Is a Mammalian Homolog of the Cell Cycle Control Protein cdc37

1997 • 70 citations

Photoaffinity labeling of thyroid hormone nuclear receptors. Influence of n-butyrate and analysis of the half-lives of the 57,000 and 47,000 molecular weight receptor forms.

1984 • 70 citations

Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions

1981 • 69 citations

Hormone‐dependent processing of the avian progesterone receptor

1988 • 69 citations

Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain.

1990 • 68 citations

Mechanism and kinetics of the thermal activation of glucocorticoid hormone receptor complex.

1976 • 67 citations

Estrogen-receptor interactions in target tissues.

1967 • 67 citations

The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein?

1993 • 67 citations

13 Modulation of Steroid Receptor Signal Transduction by Heat Shock Proteins

1994 • 67 citations

Hsp90-Mediated Folding of the Lymphoid Cell Kinase p56^lck

1996 • 66 citations

Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody.

1992 • 66 citations

Cyclophilin-40: evidence for a dimeric complex with hsp90

1995 • 65 citations

Translation of Glucocorticoid Receptor mRNA in Vitro Yields a Nonactivated Protein

1989 • 65 citations

Localization and Characterization of the 86- and 84-kDa Heat Shock Proteins in Hepa 1c1c7 Cells

1993 • 65 citations

Structural similarity of molybdate-stabilized steroid receptors in human breast tumors, uteri and leukocytes

1981 • 65 citations

Mutational analysis of hsp90 binding to the progesterone receptor.

1993 • 65 citations

Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules

1995 • 65 citations

Phosphorylation of steroid hormone receptors

1992 • 65 citations

Subunit structure of the nonactivated human estrogen receptor.

1995 • 64 citations

Purification by affinity chromatography and immunological characterization of a 110kDa component of the chick oviduct progesterone receptor

1984 • 64 citations

Chemical cross-linking of heteromeric glucocorticoid receptors

1988 • 64 citations

Studies of the glucocorticoid-binding protein from thymocytes

1970 • 64 citations

The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor.

1987 • 64 citations

Polyanionic-binding properties of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. A comparison with the glucocorticoid receptor.

1986 • 63 citations

The cytoskeleton and the cellular traffic of the progesterone receptor.

1992 • 63 citations

Activation of Steroid–Receptor Complexes

1981 • 63 citations

Calf uterine estradiol receptor. Effects of molybdate on salt-induced transformation process and characterization of a nontransformed receptor state.

1981 • 63 citations

Involvement of a non-hormone-binding 90-kilodalton protein in the nontransformed 8S form of the rabbit uterus progesterone receptor

1986 • 63 citations

Reversal of multidrug resistance by an immunosuppressive agent FK-506

1992 • 63 citations

Specific binding of glucocorticoids in vitro in the soluble fraction of mouse fibroblasts

1972 • 62 citations

Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation.

1995 • 62 citations

Kinetics of glucocorticoid-receptor complexes in rat thymus cells

1976 • 62 citations

Characteristics of an endogenous glucocorticoid receptor stabilizing factor.

1982 • 62 citations

High Level Expression of Wild Type and Variant Mouse Glucocorticoid Receptors in Chinese Hamster Ovary Cells

1990 • 61 citations

Monoclonal antibody to chicken oviduct progesterone receptor.

1983 • 61 citations

Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells.

1989 • 60 citations

Estrogen receptor activation precedes transformation. Effects of ionic strength, temperature, and molybdate.

1983 • 60 citations

Purification and structural analysis of the modulator of the glucocorticoid-receptor complex. Evidence that modulator is a novel phosphoglyceride.

1988 • 60 citations

The 59 kDa FK506-binding protein, a 90 kDa heat shock protein binding immunophilin (FKBP59-HBI), is associated with the nucleus, the cytoskeleton and mitotic apparatus

1995 • 60 citations

Three‐Step Purification of Glucocorticoid Receptors from Rat Liver

1980 • 60 citations

Chick heat-shock protein of Mr = 90,000, free or released from progesterone receptor, is in a dimeric form

1989 • 60 citations

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors

1993 • 60 citations

Molybdate permits resolution of untransformed glucocorticoid receptors from the transformed state.

1981 • 60 citations

Characterization of two 8 S forms of chick oviduct progesterone receptor.

1982 • 59 citations

Identification of the Ah receptor in selected mammalian species and induction of aryl hydrocarbon hydroxylase

1985 • 59 citations

Activated steroid-receptor complex comparison of assays using DNA-cellulose or homologous nuclei

1979 • 59 citations

THE STEROID RECEPTOR OF ACHLYA AMBISEXUALIS

1985 • 59 citations

Activation of glucocorticoid receptor by ATP

1979 • 59 citations

Immunocytochemical localization of glucocorticoid receptor in human gingival fibroblasts and evidence for a colocalization of glucocorticoid receptor with cytoplasmic microtubules.

1990 • 58 citations

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters

1986 • 58 citations

Activation of cytosolic glucocorticoid-receptor complexes in intact WEHI-7 cells does not dephosphorylate the steroid-binding protein.

1987 • 57 citations

Region-Specific Antiglucocorticoid Receptor Antibodies Selectively Recognize the Activated Form of the Ligand-Occupied Receptor and Inhibit the Binding of Activated Complexes to Deoxyribonucleic Acid

1989 • 57 citations

Conformational transitions of the estrogen receptor monomer. Effects of estrogens, antiestrogen, and temperature.

1986 • 57 citations

Identification of a Complex between Centrin and Heat Shock Proteins in CSF-Arrested Xenopus Oocytes and Dissociation of the Complex Following Oocyte Activation

1995 • 57 citations

Development of a monoclonal antibody to the rabbit 8.5S uterine progestin receptor

1985 • 56 citations

Interaction of the chicken progesterone receptor with heat shock protein (HSP) 90

1989 • 56 citations

The transformation of the cytoplasmic oestradiol–receptor complex into the nuclear complex in a uterine cell-free system

1972 • 56 citations

Analysis of the steroid receptor of Achlya ambisexualis.

1984 • 56 citations

Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions.

1994 • 55 citations

Reactivation of thymocyte glucocorticoid receptors in a cell-free system.

1977 • 55 citations

Molybdate increases intracellular 3‘,5‘-guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments.

1992 • 55 citations

Hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial stabilization by molybdate.

1986 • 54 citations

Structure of the glucocorticoid receptor in intact cells in the absence of hormone.

1992 • 53 citations

Dramatic protective effect of ligand against thermal degradation on mineralo- and glucocorticoid receptors of rat kidney

1977 • 53 citations

Characterization of a distinct glucocorticoid-binding protein in the lactating mammary gland of the rat

1973 • 53 citations

Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state.

1990 • 53 citations

Factors Modifying the Equilibrium between Activated and Non‐Activated Forms of Steroid‐Receptor Complexes

1978 • 53 citations

ATP-dependent activation of glucocorticoid receptor from rat liver cytosol

1980 • 53 citations

Activation of the dioxin and glucocorticoid receptors to a DNA binding state under cell-free conditions.

1990 • 51 citations

Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

1994 • 51 citations

In Vitro Evidence for a Progestogen Receptor in the Rat and Rabbit Uterus

1971 • 51 citations

Effects of molybdate on steroid receptors in intact GH1 cells. Evidence for dissociation of an intracellular 10 S receptor oligomer prior to nuclear accumulation.

1985 • 51 citations

Function/Activity of Specific Amino Acids in Glucocorticoid Receptors

1994 • 51 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

Biochemical properties of p60v-src mutants that induce different cell transformation parameters

1986 • 51 citations

Characterization of human mineralocorticosteroid receptor expressed in the baculovirus system.

1991 • 51 citations

Transformation of calf uterine progesterone receptor: analysis of the process when receptor is bound to progesterone and RU38486

1987 • 51 citations

Glucocorticoid-binding Macromolecules in Normal Tissues and Tumors

1972 • 51 citations

Limited proteolysis of the mouse liver glucocorticoid receptor

1983 • 51 citations

Transformation of Chick Oviduct Progesterone Receptor in Vitro: Effects of Hormone, Salt, Heat, and Adenosine Triphosphate*

1985 • 50 citations

Conformational and electrostatic properties of unoccupied and liganded estrogen receptors determined by aqueous two-phase partitioning

1985 • 50 citations

Evidence for colocalization of glucocorticoid receptor with cytoplasmic microtubules in human gingival fibroblasts, using two different monoclonal anti-GR antibodies, confocal laser scanning microscopy and image analysis

1991 • 50 citations

New in Vitro Studies of Estradiol Binding in Castrated Rat Uterus

1969 • 50 citations

Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons.

1992 • 49 citations

The chemical evolution of a nitrogenase model. 17. Simulation of steric and of inhibitory effects at the enzymic active site with acetylenes and nitriles as the substrates, and "molybdoinsulin" catalysts

1979 • 49 citations

Association of the βγ Subunits of Trimeric GTP-Binding Proteins with 90-kDa Heat Shock Protein, hsp901

1994 • 49 citations

Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells.

1990 • 49 citations

Steroid binding to hepatoma tissue culture cell glucocorticoid receptors involves at least two sulfhydryl groups.

1988 • 49 citations

A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex

1992 • 49 citations

Antibodies against Progesterone Receptor from Chick Oviduct. Cross-Reactivity with Mammalian Progesterone Receptors

1982 • 48 citations

Hsp90 Mutants Disrupt Glucocorticoid Receptor Ligand Binding and Destabilize Aporeceptor Complexes

1995 • 48 citations

The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors

1993 • 48 citations

Inactivation of chick oviduct progesterone receptors

1980 • 48 citations

Glucocorticoid receptors in ATP-depleted cells. Dephosphorylation, loss of hormone binding, HSP90 dissociation, and ATP-dependent cycling.

1994 • 47 citations

The nonactivated progesterone receptor is a nuclear heterooligomer.

1990 • 47 citations

Characterization of the Stabilizing Effect of Sodium Molybdate on the Androgen Receptor Present in Mouse Kidney*

1981 • 47 citations

Activation of Progesterone Receptor by ATP

1981 • 47 citations

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.

1992 • 47 citations

Heat shock protein HSP90 and its association with the cytoskeleton: a morphological study

1992 • 46 citations

Covalent stabilization of the nontransformed chick oviduct cytosol progesterone receptor by chemical crosslinking

1988 • 46 citations

[39] Glucocorticoid receptor thiols andsteroid-binding activity

1995 • 46 citations

Partial purification of a glucocorticoid receptor.

1975 • 46 citations

Endocrinology: New model for steroid hormone receptors?

1984 • 45 citations

Aldosterone Receptors in Rabbit Renal Cortex and Red Medulla*

1980 • 44 citations

Use of the Thiol-specific Derivatizing Agent N-Iodoacetyl-3- I iodotyrosine to Demonstrate Conformational Differences between the Unbound and hsp90-bound Glucocorticoid Receptor Hormone Binding Domain

1996 • 44 citations

83‐Kilodalton heat shock proteins of trypanosomes are potent peptide‐stimulated ATPases

1992 • 44 citations

The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class.

1994 • 43 citations

Activation and chromatographic properties of the AtT-20 mouse pituitary tumor cell line glucocorticoid receptor

1981 • 43 citations

Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor

1994 • 43 citations

Isolation of dissimilar components of the 8.5S nonactivated uterine progestin receptor

1985 • 42 citations

Detection of a pheromone-binding protein in the aquatic fungus Achlya ambisexualis

1984 • 42 citations

Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A.

1995 • 42 citations

Activation of the chick oviduct progesterone receptor by heparin in the presence or absence of hormone

1982 • 41 citations

A bacterially expressed mineralocorticoid receptor is associated in vitro with the 90-kilodalton heat shock protein and shows typical hormone- and DNA-binding characteristics

1993 • 41 citations

Microtubules Mediate Cellular 25-Hydroxyvitamin D3 Trafficking and the Genomic Response to 1,25-Dihydroxyvitamin D3 in Normal Human Monocytes

1995 • 41 citations

THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO

1970 • 41 citations

Hydrogen peroxide stabilizes the steroid-binding state of rat liver glucocorticoid receptors by promoting disulfide bond formation

1988 • 41 citations

Evidence That Heat Shock Protein-70 Associated with Progesterone Receptors Is not Involved in Receptor-DNA Binding

1991 • 41 citations

Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor

1992 • 41 citations

Isolation of untransformed bovine estrogen receptor without molybdate stabilization

1990 • 41 citations

Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex.

1994 • 41 citations

Uterine progesterone receptor: stabilization and physicochemical alterations produced by sodium molybdate

1981 • 40 citations

Evidence that the modulator of the glucocorticoid-receptor complex is the endogenous molybdate factor.

1988 • 40 citations

The Mammalian Heat Shock Protein Binding Immunophilin (p59/HBI) Is an ATP and GTP Binding Protein

1993 • 39 citations

Evidence for a phospholipid requirement in the specific binding of glucocorticoids to receptors of fibroblasts and thymic lymphocytes.

1976 • 39 citations

Redefinition of modulator as an inhibitor of glucocorticoid receptor activation

1981 • 39 citations

The dependence of specific nuclear binding of glucocorticoids by rat thymus cells on cellular ATP levels

1976 • 39 citations

The putative molybdate-stabilized progesterone receptor subunit is not a steroid-binding protein.

1984 • 39 citations

Association of the glucocorticoid receptor binding subunit with the 90K nonsteroid-binding component is stabilized by both steroidal and nonsteroidal antiglucocorticoids in intact cells

1988 • 38 citations

Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell

1992 • 38 citations

Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor

1993 • 38 citations

Binding of glucocorticoid 21-OIC acids and esters to molybdate-stabilized hepatic receptors

1981 • 38 citations

Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking

1996 • 37 citations

Characterization of the purified molybdate‐stabilized glucocorticoid receptor from rat liver

1985 • 37 citations

Tetrameric structure of the nonactivated glucocorticoid receptor in cell extracts and intact cells

1988 • 37 citations

The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor

1994 • 36 citations

In Vivo Activation and Nuclear Binding of the AtT-20 Mouse Pituitary Tumor Cell Glucocorticoid Receptor*

1983 • 36 citations

Heterotetrameric structure of the human progesterone receptor.

1992 • 36 citations

Demonstration that the 90-Kilodalton Heat Shock Protein is Bound to the Glucocorticoid Receptor in its 9S Nondeoxynucleic Acid Binding Form

1987 • 35 citations

Cytoplasmic-nuclear trafficking of steroid hormone receptors

1993 • 35 citations

The steroid-binding properties of recombinant glucocorticoid receptor: A putative role for heat shock protein hsp90

1990 • 35 citations

Analysis of glucocorticoid receptor activation by high resolution two-dimensional electrophoresis of affinity-labeled receptor.

1986 • 35 citations

Stabilization of 8S progesterone receptor from human prostate in the presence of molybdate ion.

1980 • 35 citations

Heat Shock Protein 90 Strongly Stimulates the Binding of Purified Estrogen Receptor to Its Responsive Element1

1994 • 35 citations

Interaction of glucocorticosteroid receptor and wild-type or mutated 90-kDa heat shock protein coexpressed in baculovirus-infected Sf9 cells.

1993 • 35 citations

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action

1994 • 34 citations

Nuclear progesterone receptor is mainly heat shock protein 90-free in vivo.

1993 • 34 citations

Evidence that rodent epididymal sperm contain the Mr approximately 94,000 glucocorticoid receptor but lack the Mr approximately 90,000 heat shock protein.

1992 • 34 citations

The Mr approximately 90,000 heat shock protein: an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor.

1989 • 34 citations

Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor

1988 • 33 citations

The hepatic Ah receptor for 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Species differences in subunit dissociation

1990 • 33 citations

Mineralocorticosteroid receptors in the foetal compartment

1972 • 33 citations

Purification of rat liver glucocorticoid receptor by affinity chromatography: Design of a suitable adsorbent

1981 • 33 citations

Expression and characterization of full-length and partial human androgen receptor fusion proteins. Implications for the production and applications of soluble steroid receptors in Escherichia coli

1992 • 33 citations

Cellular localization of Drosophila 83-kilodalton heat shock protein in normal, heat-shocked, and recovering cultured cells with a specific antibody

1986 • 32 citations

Corticoid binding component in rat brain

1972 • 32 citations

Ligand-regulated Nonspecific Inactivation of Receptor Function: A Versatile Mechanism for Signal Transduction

1988 • 32 citations

Evidence that the endogenous heat-stable glucocorticoid receptor stabilizing factor is a metal component of the untransformed receptor complex.

1988 • 32 citations

Macromolecular binding and metabolism of progesterone in the decidual and pseudopregnant rat and rabbit uterus☆

1971 • 31 citations

Binding of ATP to Progesterone Receptors: Properties and Functional Significance of This Interaction^*

1977 • 31 citations

Binding of progesterone receptor by nuclear preparations of rabbit and guinea pig uterus.

1976 • 30 citations

A NEW AFFINITY RESIN FOR PURIFICATION OF NON-TRANSFORMED AVIAN PROGESTERONE RECEPTOR

1982 • 30 citations

SOME FACTORS AFFECTING THE UPTAKE, BINDING AND RETENTION OF [³H]CORTISOL BY THE CHICK EMBRYO RETINA AS RELATED TO ENZYME INDUCTION

1973 • 30 citations

Antibodies to Chicken Progesterone Receptor Peptide 523–536 Recognize a Site Exposed in Receptor-Deoxyribonucleic Acid Complexes but not in Receptor-Heat Shock Protein-90 Complexes*

1989 • 29 citations

Overexpression of a Partial Human Androgen Receptor inE. coli: Characterization of Steroid Binding, DNA Binding, and Immunological Properties

1990 • 29 citations

Comparison of the 90-kilodalton heat shock protein interaction with in vitro translated glucocorticoid and estrogen receptors.

1992 • 29 citations

The antiprogesterone RU486 stabilizes the heterooligomeric, non-DNA-binding, 8S-form of the rabbit uterus cytosol progesterone receptor

1989 • 29 citations

A role for DNA in the formation of nuclear estradiol-receptor complex in a cell-free system

1971 • 29 citations

A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90

1991 • 29 citations

Rabbit FKBP-59/HBI Does Not Inhibit Calcineurin Activity in Vitro

1994 • 29 citations

Effects of ATP and pyrophosphate on properties of glucocorticoid-receptor complexes from rat thymus cells.

1983 • 28 citations

Transformation of Highly Purified Avian Progesterone Receptor*

1984 • 28 citations

The properties and functional significance of ATP binding to progesterone receptors

1976 • 28 citations

Purification and characterization of two novel phosphoglycerides that modulate the glucocorticoid-receptor complex. Evidence for two modulator binding sites in the occupied/unactivated steroid hormone receptor.

1990 • 28 citations

Association of heat shock protein 90 with the 16 kDa steroid binding core fragment of rat glucocorticoid receptors

1991 • 28 citations

In Vitro Stabilization of the Unoccupied Glucocorticoid Receptor by Adenosine 5'-Diphosphate*

1983 • 28 citations

The active transport of cortisol by mouse fibroblasts growing invitro

1968 • 27 citations

Activation of the Rat Kidney Mineralocorticoid Receptor*

1986 • 27 citations

Activation of estradiol—receptor complex by ATP in vitro

1980 • 27 citations

Effect of Phospholipases and Lysophosphatides on Partially Purified Steroid Hormone Receptors

1978 • 27 citations

Estrogen Receptor: Ambiguities in the Use of This Term

1968 • 26 citations

In vitro degradation and stabilization of the glucocorticoid binding component from mouse fibroblasts

1973 • 26 citations

Heat shock protein 70 is associated in substoichiometric amounts with the rat hepatic glucocorticoid receptor

1993 • 26 citations

Characteristics of glucocorticoid binding to mouse liver cytosol

1979 • 25 citations

Selective molybdate-directed covalent modification of sulfhydryl groups in the steroid-binding versus the DNA-binding domain of the glucocorticoid receptor.

1990 • 25 citations

Subcellular localization of the 84,000 dalton heat-shock protein in mouse neuroblastoma cells: evidence for a cytoplasmic and nuclear location.

1987 • 25 citations

Interaction of the calcium and calmodulin regulated eEF‐2 kinase with heat shock protein 90

1994 • 24 citations

Control of gene expression by steroid hormones

1986 • 24 citations

Physical characterization of the activated and non-activated forms of the glucocorticoid-receptor complex bound to the steroid antagonist [3H]RU 486

1986 • 24 citations

Localization of the Vicinal Dithiols Involved in Steroid Binding to the Rat Glucocorticoid Receptor

1990 • 23 citations

Comparison of dextran-coated charcoal and sucrose density gradient analyses of estrogen and progesterone receptors in human breast cancer.

1980 • 23 citations

Reconstitution of ligand-mediated glucocorticoid receptor activity by trans-acting functional domains.

1993 • 23 citations

Cytosolic‐nuclear Tumor Promoter‐specific Binding Protein: Association with the 90 kDa Heat Shock Protein and Translocation into Nuclei by Treatment with 12‐O‐Tetradecanoylphorbol 13‐Acetate

1991 • 23 citations

Effect of the 90 kDa heat shock protein, HSP90, on glucocorticoid receptor binding to DNA-cellulose

1988 • 22 citations

Receptor structure: A personal assessment of the current status

1986 • 22 citations

Subunit dissociation and activation of wild-type and mutant glucocorticoid receptors

1987 • 22 citations

Interaction of RNA with transformed glucocorticoid receptor. II. Identification of the RNA as transfer RNA.

1987 • 22 citations

Effect of Methylxanthines on Binding of the Glucocorticoid Receptor to DNA‐Cellulose and Nuclei

1978 • 22 citations

Stabilisation of the cytoplasmic oestrogen receptor by molybdate

1981 • 21 citations

Syrian hamster glucocorticoid receptors. Characteristics of binding of partially purified receptor to DNA.

1983 • 20 citations

Inhibition of progesterone receptor activation by vanadate

1980 • 20 citations

A specific adenine nucleotide effect on the rat liver glucocorticoid receptor, demonstrated by aqueous two-phase partitioning

1981 • 19 citations

Microtubules are not required for glucocorticoid receptor mediated gene induction

1994 • 19 citations

Possible role of glucocorticoid receptors in globin gene expression in differentiating Friend cells

1979 • 19 citations

Modulators of the glucocorticoid receptor also regulate mineralocorticoid receptor function

1992 • 19 citations

Cell cycle‐dependent association of Gag‐Mil and hsp90

1994 • 19 citations

An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus HSP56

1993 • 19 citations

Glucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2

1983 • 19 citations

Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor

1993 • 19 citations

Composition, assembly and activation of the avian progesterone receptor

1992 • 18 citations

Metal oxyanion stabilization of the rat glucocorticoid receptor is independent of thiols.

1994 • 18 citations

Study of the heteromeric structure of the untransformed glucocorticoid receptor using chemical cross-linking and monoclonal antibodies against the 90K heat-shock protein

1989 • 18 citations

RU 486 stabilizes a high molecular weight form of the glucocorticoid receptor containing the 90K non-steroid binding protein in intact thymus cells

1988 • 17 citations

The 90 000 dalton heat shock protein, a lot of smoke but no function as yet

1989 • 16 citations

The Hormone Binding Domain of the Mineralocorticoid Receptor Can Regulate Heterologous Activities in cis

1994 • 15 citations

Reconstitution of the 9 S estrogen receptor with heat shock protein 90

1990 • 13 citations

Ability of various members of the hsp70 family of chaperones to promote assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90

1996 • 13 citations

The “one and only” step model of estrogen action

1987 • 13 citations

Aluminum fluoride inhibition of glucocorticoid receptor inactivation and transformation

1990 • 12 citations

Requirement for a reduced sulphydryl entity in the protection of molybdate‐stabilized estrogen receptor

1982 • 12 citations

Energy-dependent conversion of transformed cytosolic glucocorticoid receptors from soluble to particulate-bound form

1992 • 12 citations

Modulator: the missing link

1990 • 12 citations

Glucocorticoid receptors of wild-type and variant mouse lymphoma cells

1983 • 12 citations

Control of Gene Expression by Steroid Hormones

1989 • 11 citations

Growth-Regulated Expression of FKBP-59 Immunophilin in Normal and Transformed Fibroblastic Cells

1995 • 11 citations

Purification of the endogenous glucocorticoid receptor stabilizing factor

1991 • 11 citations

Effects of Temperature, Nucleotides and Sodium Molybdate on Activation and DNA Binding of Estrogen, Glucocorticoid, Progesterone and Androgen Receptors In MCF-7 Human Cancer Cells

1981 • 10 citations

Immunological identification of a 50 kDa Mr FK506-binding immunophilin as a component of the non-DNA binding, hsp90 and hsp70 containing, heterooligomeric form of the chick oviduct progesterone receptor.

1993 • 10 citations

Reconstitution of ligand-mediated glucocorticoid receptor activity by trans-acting functional domains

1993 • 10 citations

Progesterone receptor and hsp90 are not complexed in intact nuclei

1994 • 9 citations

Effects of sodium tungstate on the nuclear uptake of glucocorticoid-receptor complex from rat liver

1982 • 9 citations

Endogenous modulators of glucocorticoid receptor function also regulate purified protein kinase C.

1991 • 8 citations

Role of heat-shock proteins in steroid receptor function

1993 • 8 citations

Heparin-mediated inactivation and transformation of mammary cytoplasmic glucocorticoid receptor

1984 • 8 citations

ATP-induced activation of purified rat hepatic glucocorticoid receptors

1987 • 7 citations

Interaction of chick oviduct progesterone receptor with the 2',3'-dialdehyde derivatives of adenosine 5'-triphosphate

1983 • 7 citations

Interaction of heparin with the cytosol progesterone receptor from human mammary tumours: Separate estimation of the 4 and 7 S binding components with a simple dextran—charcoal assay

1981 • 7 citations

The Functional Relevance of the Heteromeric Structure of Corticosteroid Receptorsa

1994 • 6 citations

131. Cross-reactivity of anti-chick oviduct progesterone receptor antibodies with glucocorticosteroid receptor

1982 • 3 citations