ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Principles of Fluorescence Spectroscopy

1999 • 27,045 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of protein conformation

1974 • 3,327 citations

Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range

1972 • 2,632 citations

CONTIN: A general purpose constrained regularization program for inverting noisy linear algebraic and integral equations

1982 • 2,621 citations

Estimation of globular protein secondary structure from circular dichroism

1981 • 2,139 citations

Atomic structure of the actin: DNase I complex

1990 • 1,897 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

New insight into protein secondary structure from resolution-enhanced infrared spectra

1988 • 1,248 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Principles of fluorescence spectroscopy

1984 • 1,031 citations

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.

1992 • 805 citations

Stress protein systems of mammalian cells

1986 • 564 citations

Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

1979 • 452 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.

1986 • 338 citations

Heat shock and the heat shock proteins

1986 • 336 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.

1985 • 327 citations

The dnaK protein of Escherichia coli possesses an ATPase and autophosphorylating activity and is essential in an in vitro DNA replication system.

1983 • 260 citations

Inhibition of progesterone receptor activation by sodium molybdate

1980 • 257 citations

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein.

1981 • 246 citations

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein

1991 • 245 citations

Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes.

1990 • 221 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

Transition metal ion inhibition of enzyme-catalyzed phosphate ester displacement reactions

1974 • 200 citations

Glucocorticoid receptor inactivation under cell-free conditions.

1977 • 196 citations

Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II

1989 • 190 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Heat Shock Protein-mediated Disassembly of Nucleoprotein Structures Is Required for the Initiation of Bacteriophage λ DNA Replication

1989 • 165 citations

Murine 86- and 84-kDa Heat Shock Proteins, cDNA Sequences, Chromosome Assignments, and Evolutionary Origins

1989 • 154 citations

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1991 • 147 citations

Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels.

1990 • 147 citations

Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts.

1985 • 143 citations

ATP-dependent activation of L cell glucocorticoid receptors to the steroid binding form.

1979 • 140 citations

Ordered Assembly of Nucleoprotein Structures at the Bacteriophage λ Replication Origin during the Initiation of DNA Replication

1989 • 135 citations

The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

1987 • 130 citations

Evidence that the 90-Kilodalton Heat Shock Protein is Associated with Tubulin-Containing Complexes in L Cell Cytosol and in Intact PtK Cells

1988 • 122 citations

Aggregated dnaA protein is dissociated and activated for DNA replication by phospholipase or dnaK protein.

1990 • 119 citations

DnaK, hsp73, and their molten globules. Two different ways heat shock proteins respond to heat.

1992 • 118 citations

Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins.

1982 • 116 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase.

1989 • 110 citations

Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors

1987 • 77 citations

51V-n.m.r. analysis of the binding of vanadium(V) oligoanions to sarcoplasmic reticulum

1985 • 70 citations

The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals A “DNA like” structure: Potential site of interaction with steroid receptors

1989 • 64 citations

Secondary structure of the mammalian 70-kilodalton heat shock cognate protein analyzed by circular dichroism spectroscopy and secondary structure prediction

1990 • 60 citations

ATP-dependent activation of glucocorticoid receptor from rat liver cytosol

1980 • 53 citations

The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins

1982 • 49 citations

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.

1992 • 47 citations

Calcium-dependent autophosphorylation of the glucose-regulated protein, Grp78

1991 • 46 citations

Purification and characterization of the 90-kDa heat-shock protein from mammalian tissues

1988 • 35 citations

Selective molybdate-directed covalent modification of sulfhydryl groups in the steroid-binding versus the DNA-binding domain of the glucocorticoid receptor.

1990 • 25 citations

Characterization of the Hydrophobic Region of Heat Shock Protein 90

1991 • 23 citations

Temperature‐dependent oligomerization of hsp85 in vitro

1989 • 16 citations