An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Protein folding in the cell

1992 • 4,138 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Heat shock proteins.

1990 • 1,365 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 • 641 citations

Hydrophobic cluster analysis: An efficient new way to compare and analyse amino acid sequences

1987 • 616 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Cellulase families revealed by hydrophobic cluster analysi

1989 • 390 citations

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1990 • 353 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin

1991 • 302 citations

Hydrophobic cluster analysis: procedures to derive structural and functional information from 2-D-representation of protein sequences

1990 • 300 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes.

1990 • 221 citations

Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein

1991 • 213 citations

DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity

1989 • 212 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.

1991 • 173 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1990 • 160 citations

The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein.

1985 • 156 citations

Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

1991 • 152 citations

Solution structure of the major binding protein for the immunosuppressant FK506

1991 • 146 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

Cellulase EGZ of Erwinia chrysanthemi: structural organization and importance of His98 and Glu133 residues for catalysis

1991 • 126 citations

When worlds collide: Immunosuppressants meet protein phosphatases

1991 • 114 citations

Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product

1991 • 77 citations

Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Neisseria gonorrhoeae pil sequences

1988 • 72 citations

The steroid/thyroid hormone receptor family and gene regulation

1990 • 25 citations

Cyclosporine suppression of intracellular activation signal generation is not mediated by prolyl-peptidyl isomerase.

1991 • 1 citations

Cyclosporine suppression of intracellular activation signal generation is not mediated by prolyl-peptidyl isomerase.

1991 • 1 citations