Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Molybdate inhibition of glucocorticoid receptor inactivation and transformation.

1979 • 339 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

1986 • 295 citations

Coming in from the cold

1988 • 285 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 • 267 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

1992 • 252 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

1990 • 190 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.

1994 • 169 citations

Effects of Molybdate and Endogenous Inhibitors on Steroid-Receptor Inactivation, Transformation, and Translocation

1984 • 153 citations

Reconstitution of Progesterone Receptor with Heat Shock Proteins

1990 • 149 citations

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

1993 • 133 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Monovalent cation selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90.

1992 • 101 citations

A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.

1991 • 101 citations

Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90

1991 • 100 citations

Control of steroid receptor function and cytoplasmic‐nuclear transport by heat shock proteins

1992 • 100 citations

Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.

1992 • 93 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex

1990 • 78 citations

Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody.

1992 • 66 citations

High Level Expression of Wild Type and Variant Mouse Glucocorticoid Receptors in Chinese Hamster Ovary Cells

1990 • 61 citations

Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state.

1990 • 53 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex

1992 • 49 citations

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.

1992 • 47 citations

Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell

1992 • 38 citations