Evolution of a Model of Estrogen Action

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Partition of Cell Particles and Macromolecules

1973 • 2,047 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Nuclear localization of unoccupied oestrogen receptors

1984 • 882 citations

Current Models of Steroid Hormone Action: A Critique

1976 • 707 citations

PROTEIN-NUCLEIC ACID INTERACTIONS IN TRANSCRIPTION: A Molecular Analysis

1984 • 620 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Transport of Protein-Bound Hormones into Tissuesin Vivo*

1981 • 435 citations

Actively transcribed genes are associated with the nuclear matrix

1983 • 396 citations

The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells

1982 • 356 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Thyroid Hormone Action in Cell Culture: Demonstration of Nuclear Receptors in Intact Cells and Isolated Nuclei

1973 • 337 citations

Immunocytochemical Study of Mammalian Progesterone Receptor Using Monoclonal Antibodies*

1985 • 319 citations

Uterine, cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. Assay of empty and filled sites by exchange

1973 • 288 citations

Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding

1984 • 281 citations

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult β-globin gene: Nature of the binding domain

1985 • 255 citations

Biological Activities of Steroids in Relation to Cancer

1961 • 232 citations

Unexpected relationships between four large deletions in the human β-globin gene cluster

1983 • 218 citations

The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor.

1985 • 215 citations

Differential Response of Individual Uterine Cell Types from Immature Rats Treated with Estradiol*

1980 • 210 citations

Specific binding of the glucocorticoid-receptor complex to the mouse mammary tumor proviral promoter region

1982 • 181 citations

Equilibrium: the intracellular distribution of steroid receptors

1979 • 176 citations

Positive cooperativity of the estrogen receptor.

1981 • 173 citations

Nuclear Localization of Unoccupied Receptors for Glucocorticoids, Estrogens, and Progesterone in GH³Cells*

1985 • 172 citations

Progesterone receptor in the chick oviduct: an immunohistochemical study with antibodies to distinct receptor components.

1984 • 164 citations

Unoccupied 1,25-dihydroxyvitamin D3 receptors. Nuclear/cytosol ratio depends on ionic strength.

1980 • 161 citations

In Vitro Conversion of Estradiol-Receptor Protein to Its Nuclear Form: Dependence on Hormone and DNA

1972 • 145 citations

Immunocytochemical Localization of Estrogen Receptors in the Macaque Reproductive Tract with Monoclonal Antiestrophilins*

1984 • 132 citations

Estrogen receptor. Unoccupied sites in nuclei of a breast tumor cell line.

1977 • 131 citations

The Nuclear Envelope and the Nuclear Matrix

1983 • 123 citations

Kinetic and Equilibrium Analysis of Estradiol in Uterus: A Model of Binding-Site Distribution in Uterine Cells

1972 • 122 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding.

1984 • 120 citations

Selective Binding of the Estradiol Receptor to a Region at Least One Kilobase Upstream From the Rat Prolactin Gene

1985 • 112 citations

Biochemical Actions of Hormones

1983 • 111 citations

Molecular Mechanism of Steroid Hormone Action

1985 • 94 citations

The molecular biology of hormone action

1976 • 75 citations

Lysosomal Functions in Cellular Activation: Propagation of the Actions of Hormones and Other Effectors

1984 • 75 citations

An in vitro system for the binding of estradiol to rat uterine nuclei

1967 • 73 citations

Modulation of the estrogen receptor's affinity for DNA by estradiol.

1985 • 73 citations

Estrogen Regulates the Transcription of the Rat Prolactin Genein Vivothrough at Least Two Independent Mechanisms*

1985 • 61 citations

Mechanism for the selection of nuclear polypeptides in Xenopus oocytes.

1978 • 57 citations

Subcellular compartmentalization of estrogen receptors in human breast cancer cells

1980 • 56 citations

Estriol and estrone interaction with the estrogen receptor. I. Temperature-induced modulation of the cooperative binding of [3H]estriol and [3H]estrone to the estrogen receptor.

1983 • 54 citations

Intracellular localization of mouse DNA polymerase-alpha.

1976 • 53 citations

Estrogen Binding in the Rat and Human

1973 • 53 citations

Immunohistochemical localization of estrogen receptors in human mammary carcinoma using antibodies to the receptor protein

1982 • 52 citations

Conformational and electrostatic properties of unoccupied and liganded estrogen receptors determined by aqueous two-phase partitioning

1985 • 50 citations

Estrogen receptor transformation to a high-affinity state without subunit-subunit interactions

1984 • 47 citations

Translocation of cytoplasmic estrogen receptors to the nucleus: Immunohistochemical demonstration utilizing rabbit antibodies to estrogen receptors of mammary carcinomas

1983 • 36 citations

Kinetics of Estradiol Entry into Uterine Cells*

1979 • 35 citations

Rat Uterine Growth and Induction of Progesterone Receptor without Estrogen Receptor Translocation*

1985 • 32 citations

Ultraviolet photosensitivity of the estrogen binding protein from rat uterus. Wavelength and ligand dependence. Photocovalent attachment of estrogens to protein

1975 • 31 citations

Unbound Progesterone Receptors Are in Equilibrium between the Nucleus and Cytoplasm in Cells of the Rat Uterus*

1981 • 30 citations

Histone‐Hydrocarbon Interaction. Partition of Histones in Aqueous Two‐Phase Systems Containing Poly(ethylene glycol)‐Bound Hydrocarbons

1976 • 30 citations

Activation and Partial Proteolysis of Variant Glucocorticoid Receptors, Studied by Two‐Phase Partitioning

1981 • 29 citations

Gene expression: Protein contacts for promoter location in eukaryotes

1983 • 27 citations

Conversion of Estrogen Receptor from a State with Low Affinity for Estradiol into a State of Higher Affinity Does Not Require 4S to 5S Dimerization*

1985 • 27 citations

Aqueous two-phase partition studies of the glucocorticoid receptor activation and pH-dependent changes of rat liver glucocorticoid-receptor complex in partly purified preparations

1980 • 20 citations

Comparison of formation, activation, and nuclear translocation of receptor . estradiol (R . E2) complex at 0 degrees C and 37 degrees C in intact uterine cells.

1979 • 20 citations

Changes in net charge of glucocorticoid receptors by activation, and evidence for a biphasic activation kinetics

1982 • 20 citations

A specific adenine nucleotide effect on the rat liver glucocorticoid receptor, demonstrated by aqueous two-phase partitioning

1981 • 19 citations

Conversions of the glucocorticoid · receptor complex of rat thymocyte cytosol, studied by partition in an aqueous dextra-polyethylene glycol two-phase system

1978 • 19 citations

Estradiol‐receptor‐DNA interaction: Liquid polymer phase partition

1976 • 18 citations

The Mechanism of 17β-Estradiol Uptake into Prolactin-Producing Rat Pituitary Cells (GH₃Cells) in Culture*

1985 • 16 citations

Estradiol Receptors: A New Evaluation

1973 • 7 citations

DNA-binding proteins (reply)

1984 • 5 citations