Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Endocrine Pharmacology of Antiestrogens as Antitumor Agents*

1990 • 403 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Steroid receptor analyses of nine human breast cancer cell lines.

1978 • 300 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists.

1995 • 230 citations

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen.

1993 • 215 citations

Identification of multiple, widely spaced estrogen-responsive regions in the rat progesterone receptor gene.

1994 • 191 citations

Inhibitory Cross-Talk between Steroid Hormone Receptors: Differential Targeting of Estrogen Receptor in the Repression of Its Transcriptional Activity by Agonist- and Antagonist-Occupied Progestin Receptors

1995 • 187 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters.

1993 • 169 citations

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells

1991 • 128 citations

Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor. Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands

1991 • 100 citations

Pseudosubstrates turn off protein kinases

1988 • 81 citations

A ligand-induced conformational change in the estrogen receptor is localized in the steroid binding domain

1992 • 62 citations

Protein kinases: A diverse family of related proteins

1987 • 46 citations

Cross-Linking of Estrogen Receptor to Chromatin in Intact MCF-7 Human Breast Cancer Cells: Optimization and Effect of Ligand

1990 • 40 citations