Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

R 24571: A new powerful inhibitor of red blood cell Ca++-transport ATPase and of calmodulin-regulated functions

1981 • 260 citations

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

1992 • 252 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

Phosphorylation of Steroid Hormone Receptors*

1992 • 243 citations

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast

1992 • 195 citations

Binding of heat shock proteins to the avian progesterone receptor.

1989 • 192 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin.

1993 • 137 citations

Rapamycin and FK506 binding proteins (immunophilins)

1991 • 136 citations

Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites.

1990 • 131 citations

Phosphorylation of steroid receptors

1989 • 100 citations

Monoclonal and Polyclonal Antibodies to Human Progesterone Receptor Peptide-(533-547) Recognize a Specific Site In Unactivated (8S) and Activated (4S) Progesterone Receptor and Distinguish between Intact and Proteolyzed Receptors*

1990 • 78 citations

Synthesis of Human Progesterone Receptors in T47D Cells

1989 • 64 citations

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors

1993 • 60 citations

Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.

1992 • 55 citations

Activation of an inactive immunophilin by mutagenesis

1993 • 45 citations

cDNA Cloning of a human 5 kDa FK506 and rapamycin binding protein

1992 • 42 citations

Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites

1993 • 23 citations