Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

Gene regulation by steroid hormones

1989 • 3,466 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

1988 • 268 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

1988 • 198 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite

1982 • 168 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

1992 • 155 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.

1990 • 146 citations

The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription.

1990 • 139 citations

Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis-Acting Elements during Induction

1989 • 126 citations

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

1989 • 111 citations

Characterization of the transcription activation function and the DNA binding domain of transcriptional enhancer factor-1.

1993 • 100 citations

High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein

1991 • 99 citations

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1992 • 85 citations

Circadian Clock Genes Are Ticking

1992 • 79 citations

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

1992 • 77 citations

Activation of the dioxin and glucocorticoid receptors to a DNA binding state under cell-free conditions.

1990 • 51 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations

A hydroxylapatite microassay for receptor binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene in various target tissues

1985 • 40 citations

Ligand-Dependent Recruitment of the Arnt Coregulator Determines DNA Recognition by the Dioxin Receptor

1993 • 38 citations

Radiosequence analysis of the human progestin receptor charged with [3H]promegestone. A comparison with the glucocorticoid receptor.

1990 • 35 citations

Conformational Activation of a Basic Helix-Loop-Helix Protein (MyoDl) by the C-Terminal Region of Murine HSP90 (HSP84)

1992 • 26 citations

Dioxin-Dependent Activation of Murine Cypla-1 Gene Transcription Requires Protein Kinase C-Dependent Phosphorylation

1992 • 22 citations

Cross-Coupling of Signal Transduction Pathways: the Dioxin Receptor Mediates Induction of Cytochrome P-450IA1 Expression via a Protein Kinase C-Dependent Mechanism

1993 • 21 citations

Role of the Ligand in Intracellular Receptor Function: Receptor Affinity Determines Activation In Vitro of the Latent Dioxin Receptor to a DNA-Binding Form

1991 • 11 citations