Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

1993 • 266 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

1990 • 190 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition

1991 • 165 citations

Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state.

1991 • 163 citations

Reconstitution of Progesterone Receptor with Heat Shock Proteins

1990 • 149 citations

Mapping the HSP90 binding region of the glucocorticoid receptor.

1990 • 144 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor.

1988 • 123 citations

A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.

1991 • 101 citations

Monovalent cation selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90.

1992 • 101 citations

Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.

1992 • 93 citations

Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.

1988 • 92 citations

Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.

1991 • 83 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

FK506 binding to the 56-kilodalton immunophilin (hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function

1993 • 78 citations

Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex

1990 • 78 citations

Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody.

1992 • 66 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex

1992 • 49 citations

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.

1992 • 47 citations

Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell

1992 • 38 citations

Association of heat shock protein 90 with the 16 kDa steroid binding core fragment of rat glucocorticoid receptors

1991 • 28 citations