Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Protein folding in the cell

1992 • 4,138 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Evolution of the alpha-crystallin/small heat-shock protein family.

1993 • 464 citations

Molecular chaperones in protein folding: the art of avoiding sticky situations

1994 • 402 citations

Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.

1993 • 375 citations

Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein.

1988 • 356 citations

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli

1992 • 299 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

1993 • 266 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.

1994 • 190 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

1992 • 155 citations

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1991 • 147 citations

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.

1994 • 132 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

α-Crystallin, a Molecular Chaperone, Forms a Stable Complex with Carbonic Anhydrase upon Heat Denaturation

1993 • 116 citations

The calmodulin-binding domain of the mouse 90-kDa heat shock protein

1993 • 97 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes

1993 • 95 citations

Denaturation of proteins during heat shock. In vivo recovery of solubility and activity of reporter enzymes

1991 • 82 citations

Mutational analysis of hsp90 binding to the progesterone receptor.

1993 • 65 citations

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors

1993 • 60 citations

Steroid Hormone Receptors: Basic and Clinical Aspects

1994 • 18 citations