Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Oncogenes and signal transduction

1991 • 2,816 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

Isolation of the yeast calmodulin gene: Calmodulin is an essential protein

1986 • 400 citations

Functional homology of mammalian and yeast RAS genes

1985 • 324 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1988 • 292 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

INOSITOL-REQUIRING MUTANTS OF SACCHAROMYCES CEREVISIAE

1975 • 230 citations

myo-Inositol-1-phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast.

1981 • 228 citations

Affinity chromatography of protein kinase C-phorbol ester receptor on polyacrylamide-immobilized phosphatidylserine.

1984 • 205 citations

THE SYNTHESIS AND FUNCTION OF PROTEASES IN SACCHAROMYCES: GENETIC APPROACHES

1984 • 179 citations

A major 125-kd membrane glycoprotein of Saccharomyces cerevisiae is attached to the lipid bilayer through an inositol-containing phospholipid.

1988 • 161 citations

Rapid purification of protein kinase C by high performance liquid chromatography

1986 • 160 citations

Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.

1987 • 151 citations

Studies on the Diversity of Inositol-Containing Yeast Phospholipids: Incorporation of 2-Deoxyglucose into Lipid

1972 • 139 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

1991 • 131 citations

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990 • 129 citations

Bovine brain contains two types of phosphatidylinositol kinase

1987 • 125 citations

Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote.

1991 • 123 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.

1986 • 118 citations

The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes.

1990 • 111 citations

Characteristics of rat liver phosphatidylinositol kinase and its presence in the plasma membrane

1967 • 91 citations

Small GTP-binding proteins

1989 • 74 citations

Purification and characterization of a phosphatidylinositol kinase from A431 cells

1988 • 72 citations

Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri.

1988 • 62 citations

Stimulation of cell proliferation and polyphosphoinositide metabolism in Saccharomycescerevisiae GL7 by ergosterol

1985 • 54 citations

Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae.

1988 • 54 citations

Phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Kinetic analysis using Triton X-100/phosphatidylinositol-mixed micelles

1991 • 50 citations

A role for membrane-inserted protein kinase C in cellular memory?

1989 • 34 citations

Synthesis of diphosphoinositide by a soluble fraction of Saccharomyces cerevisiae

1974 • 21 citations

Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus

1989 • 20 citations

SOLUBILIZATION OF MEMBRANE ASSOCIATED PHOSPHATIDYLINOSITOL KINASE FROM SACCHAROMYCES CEREVISIAE

1982 • 12 citations

Phosphatidylinositol kinases from rabbit reticulocytes

1987 • 11 citations

Phosphatidylinositol kinase activity inSaccharomyces cerevisiae

1972 • 11 citations