Mitochondrial dysfunction in cardiovascular disease

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Beyond Cholesterol

1989 • 6,533 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Mitochondrial formation of reactive oxygen species

2003 • 3,947 citations

Mitochondrial formation of reactive oxygen species

2003 • 3,907 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic Neuropathy

1988 • 2,368 citations

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

1990 • 2,006 citations

Free Radicals in Biology

1976 • 1,879 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence

1991 • 1,603 citations

[10] Superoxide dismutase assays

1984 • 1,468 citations

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation

1990 • 1,456 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,435 citations

Biological Action of Leptin as an Angiogenic Factor

1998 • 1,390 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,341 citations

Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease

1996 • 1,323 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Generation of reactive oxygen species by the mitochondrial electron transport chain

2002 • 1,208 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Postmenopausal Hormone Therapy and Mortality

1997 • 1,184 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Postmenopausal Hormone Replacement Therapy

2002 • 986 citations

Cell Biology of Atherosclerosis

1995 • 982 citations

A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.

1990 • 981 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Adverse effects of reverse transcriptase inhibitors

1998 • 853 citations

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

1997 • 840 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Mitochondrial toxicity of antiviral drugs

1995 • 760 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

2001 • 686 citations

Leptin induces oxidative stress in human endothelial cells

1999 • 682 citations

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

2000 • 666 citations

Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations

2004 • 657 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

1997 • 620 citations

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

2001 • 620 citations

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1992 • 612 citations

Myeloperoxidase-generated oxidants and atherosclerosis

2000 • 607 citations

Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B

1995 • 605 citations

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

2004 • 600 citations

Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males

2003 • 596 citations

Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries

2002 • 589 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

The Role of Endothelium in Cardiovascular Homeostasis and Diseases

1993 • 558 citations

The missing link: A single unifying mechanism for diabetic complications

2000 • 517 citations

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1991 • 511 citations

Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress

2000 • 510 citations

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1998 • 509 citations

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1998 • 506 citations

Mitochondrial localization of estrogen receptor β

2004 • 486 citations

Heteroplasmic mtDNA mutation (T----G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.

1992 • 476 citations

Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima

1997 • 470 citations

Mitochondrial Integrity and Function in Atherogenesis

2002 • 459 citations

Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

2004 • 457 citations

Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress

2003 • 452 citations

Consequences of the diabetic status on the oxidant/antioxidant balance.

2000 • 441 citations

Hydrogen Peroxide– and Peroxynitrite-Induced Mitochondrial DNA Damage and Dysfunction in Vascular Endothelial and Smooth Muscle Cells

2000 • 433 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium

2000 • 423 citations

The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women

1995 • 423 citations

Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques

2002 • 420 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β

2000 • 362 citations

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

1992 • 354 citations

Overexpression of MnSOD Protects Against Myocardial Ischemia/reperfusion Injury in Transgenic Mice

1998 • 351 citations

Cytochrome c Nitration by Peroxynitrite

2000 • 348 citations

The risk of acute myocardial infarction after oestrogen and oestrogen‐progestogen replacement

1992 • 331 citations

Transport Function and Regulation of Mitochondrial Uncoupling Proteins 2 and 3

1999 • 326 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

NADH Oxidase Activation Is Involved in Arsenite-Induced Oxidative DNA Damage in Human Vascular Smooth Muscle Cells

2000 • 316 citations

Postmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease

2002 • 314 citations

Uncoupling Protein-2 Overexpression Inhibits Mitochondrial Death Pathway in Cardiomyocytes

2003 • 311 citations

Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium

1997 • 288 citations

Increased Formation of Distinct F ₂ Isoprostanes in Hypercholesterolemia

1998 • 276 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Mitochondrial localization of ERα and ERβ in human MCF7 cells

2004 • 264 citations

Biological Gradient Between Long-Term Arsenic Exposure and Carotid Atherosclerosis

2002 • 259 citations

Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

1995 • 258 citations

Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression

2003 • 258 citations

Eosinophil Peroxidase Nitrates Protein Tyrosyl Residues

1999 • 257 citations

Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels

2002 • 256 citations

Protective Role of Uncoupling Protein 2 in Atherosclerosis

2003 • 237 citations

A new mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF).

1992 • 226 citations

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

2003 • 222 citations

IPF _2α -I: An index of lipid peroxidation in humans

1998 • 218 citations

Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues

2002 • 215 citations

Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria

2003 • 213 citations

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.

1992 • 209 citations

A Mitochondrial Paradigm for Degenerative Diseases and Ageing

2001 • 207 citations

Hydrogen Peroxide Causes Significant Mitochondrial DNA Damage in Human RPE Cells

1999 • 206 citations

c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation

2001 • 199 citations

Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway

2001 • 199 citations

Chemical and biochemical aspects of superoxide and superoxide dismutase

1981 • 197 citations

Amelioration of Ischemia- and Reperfusion-Induced Myocardial Injury by 17β-Estradiol

1997 • 180 citations

Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

2002 • 170 citations

α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α

2002 • 169 citations

Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray

2002 • 168 citations

Oxidative DNA Damage and Repair in Experimental Atherosclerosis Are Reversed by Dietary Lipid Lowering

2001 • 168 citations

Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells

2003 • 168 citations

Mitochondrial proton leak and the uncoupling protein 1 homologues

2001 • 165 citations

Passive Smoking Affects Endothelium and Platelets

1989 • 160 citations

Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure

1998 • 158 citations

Subacute necrotizing encephalopathy

1992 • 154 citations

Mitochondria, nitric oxide, and cardiovascular dysfunction

2002 • 149 citations

Mitochondrial Theory of Aging: Importance to Explain Why Females Live Longer Than Males

2003 • 145 citations

Nitrite as a Substrate and Inhibitor of Myeloperoxidase

2000 • 141 citations

Binding of MCF‐7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial dna estrogen response elements

2004 • 138 citations

[4] Measuring nitric oxide and superoxide: Rate constants for aconitase reactivity

1996 • 136 citations

Reactive Oxygen Species Are Involved in Arsenic Trioxide Inhibition of Pyruvate Dehydrogenase Activity

2003 • 136 citations

Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses

2001 • 132 citations

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

2003 • 132 citations

Induction of Nuclear Factor κB after Low-Dose Ionizing Radiation Involves a Reactive Oxygen Intermediate Signaling Pathway

1994 • 131 citations

Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability

2003 • 126 citations

Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice.

2003 • 124 citations

Postischemic Recovery of Contractile Function is Impaired in SOD2 ^+/− but Not SOD1 ^+/− Mouse Hearts

2002 • 124 citations

Mitochondrial Function Is Required for Hydrogen Peroxide-induced Growth Factor Receptor Transactivation and Downstream Signaling

2004 • 123 citations

Oxidized LDL Promotes Peroxide-Mediated Mitochondrial Dysfunction and Cell Death in Human Macrophages

2003 • 117 citations

Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle

2002 • 116 citations

Inhalation of steady-state sidestream smoke from one cigarette promotes arteriosclerotic plaque development.

1994 • 115 citations

Mechanisms of Cell Signaling by Nitric Oxide and Peroxynitrite: From Mitochondria to MAP Kinases

2001 • 114 citations

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

2000 • 114 citations

Subcellular distribution of native estrogen receptor α and β isoforms in rabbit uterus and ovary

2001 • 113 citations

Protein Oxidation of Cytochrome c by Reactive Halogen Species Enhances Its Peroxidase Activity

2002 • 109 citations

Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis

1998 • 109 citations

A Reappraisal of Xanthine Dehydrogenase and Oxidase in Hypoxic Reperfusion Injury: the Role of NADH as an Electron Donor

1998 • 107 citations

Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits

1997 • 106 citations

Cardioprotective Effects of 17β-Estradiol Produced by Activation of Mitochondrial ATP-Sensitive K+Channels in Canine Hearts

2000 • 106 citations

Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.

1996 • 106 citations

A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity

1993 • 104 citations

Estrogen Regulation of Endothelial and Smooth Muscle Cell Migration and Proliferation

2002 • 104 citations

Chemical and biochemical aspects of superoxide and superoxide dismutase

1980 • 103 citations

Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion

1989 • 103 citations

17β-Estradiol Prevents Dysfunction of Canine Coronary Endothelium and Myocardium and Reperfusion Arrhythmias After Brief Ischemia/Reperfusion

1996 • 102 citations

DNA Damage as a New Emerging Risk Factor in Atherosclerosis

2003 • 101 citations

Myoclonus epilepsy associated with ragged-red fibers: A G-to-A mutation at nucleotide pair 8363 in mitochondrial tRNALys in two families

1997 • 90 citations

Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice

2002 • 90 citations

Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration

2003 • 87 citations

Estrogen's Effects on Mitochondrial Gene Expression: Mechanisms and Potential Contributions to Estrogen Carcinogenesis

2004 • 85 citations

17β-Estradiol as a Receptor-Mediated Cardioprotective Agent

2003 • 85 citations

Estradiol reverses TGF-β1-stimulated type IV collagen gene transcription in murine mesangial cells

1998 • 76 citations

Circulating Xanthine Oxidase in Human Ischemia Reperfusion

1995 • 76 citations

Mitochondrial Function Is Involved in LDL Oxidation Mediated by Human Cultured Endothelial Cells

1997 • 75 citations

Cytotoxicity of oxidized low‐density lipoprotein to mouse peritoneal macrophages: An ultrastructural study

1993 • 73 citations

DNA-adducts and atherosclerosis: a study of accidental and sudden death males in the Czech Republic

2002 • 73 citations

Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases

1995 • 72 citations

Decreased Superoxide Dismutase Activity and Increased Superoxide Anion Production in Cardiac Hypertrophy of Spontaneously Hypertensive Rats

1995 • 71 citations

Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease

2004 • 69 citations

Smoke cardiomyopathy: disturbance of oxidative processes in myocardial mitochondria

1984 • 69 citations

Effect of Smoking on the Oxidative Processes of Cardiomyocytes

1992 • 68 citations

Mechanism of uncoupling protein action

2001 • 67 citations

Estrogen for women at varying risk of coronary disease

1998 • 66 citations

Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins

2003 • 65 citations

Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessels of long-term cholesterol-fed rabbits

1999 • 64 citations

Mechanism of uncoupling protein action

2001 • 63 citations

Increased Sensitivity of Mitochondrial Respiration to Inhibition by Nitric Oxide in Cardiac Hypertrophy

2001 • 60 citations

Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis

2002 • 60 citations

Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice

2001 • 60 citations

Ischemia- and reperfusion-induced ventricular arrhythmias in dogs: effects of estrogen

1995 • 60 citations

High incidence of pre‐excitation syndrome in Japanese families with Leber's hereditary optic neuropathy

1996 • 59 citations

Oxidized low-density lipoprotein and 15-deoxy-Δ^12,14-PGJ₂increase mitochondrial complex I activity in endothelial cells

2003 • 59 citations

Growth Regulatory Mechanisms and Formation of the Lesions of Atherosclerosis^a

1994 • 58 citations

Differential cellular localization of estrogen receptor α in uterine and mammary cells

2001 • 58 citations

Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E ^−/− Mice Fed a Chow Diet

2004 • 57 citations

Differential Effects of Sarcolemmal and Mitochondrial K_ATP Channels Activated by 17β-Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts

2002 • 56 citations

Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line

2003 • 56 citations

The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania

2001 • 54 citations

Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat

2004 • 50 citations

Atherosclerosis in AIDS: Potential Pathogenetic Roles of Antiretroviral Therapy and HIV

2000 • 48 citations

Uncoupling protein 3 and fatty acid metabolism

2001 • 47 citations

Life without UCPI: mitochondrial, cellular and organismal characteristics of the UCPI-ablated mice

2001 • 46 citations

Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease

1991 • 46 citations

Uncoupling protein, H+ transport and regulation

2001 • 44 citations

Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus

1997 • 44 citations

Passive smoking affects endothelium and platelets

1989 • 43 citations

Mitochondrial signals to nucleus regulate estrogen-induced cell growth

2004 • 42 citations

Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes.

1995 • 41 citations

Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions

1999 • 41 citations

Rapid Uptake and Binding of Estradiol-17β-6-(O-carboxymethyl)oxime:125I-labeled Bsa by Female Rat Liver1

1998 • 41 citations

Early growth responsive‐1‐dependent manganese superoxide dismutase gene transcription mediated by platelet‐derived growth factor

2001 • 41 citations

Exposure of rats to low concentration of cigarette smoke increases myocardial sensitivity to ischaemia/reperfusion

1992 • 39 citations

Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype

1998 • 39 citations

Serum Leptin Levels in Young Females with Insulin-Dependent Diabetes and the Relationship to Hyperandrogenicity and Microalbuminuria

1998 • 38 citations

Protective role of manganese superoxide dismutase against cigarette smoke‐induced cytotoxicity

1994 • 37 citations

Atherogenic levels of low-density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: Possible mechanism of heightened endocytosis

1996 • 34 citations

The effect of smoking on myocardial metabolism.

1987 • 33 citations

Captopril increased mitochondrial coenzyme Q₁₀ level, improved respiratory chain function and energy production in the left ventricle in rabbits with smoke mitochondrial cardiomyopathy

1999 • 30 citations

Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes

1995 • 30 citations

High Glucose Concentrations Induce Oxidative Damage to Mitochondrial DNA in Explanted Vascular Smooth Muscle Cells

2001 • 28 citations

Antioxidant Vitamin Supplementation of Smoke-Exposed Rats Partially Protects Against Myocardial Ischaemic/Reperfusion Injury

1992 • 27 citations

Reproductive hormones and cardiovascular disease

2002 • 25 citations

The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase

1998 • 24 citations

Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes

2002 • 21 citations

Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease

2004 • 16 citations

Relationship of Estrogen Therapy for Carcinoma of the Prostate to Atherosclerotic Cardiovascular Disease: A Clinicopathologic Study

1970 • 16 citations

Inhibition of estrogen receptor function promotes porcine coronary artery smooth muscle cell proliferation

1999 • 11 citations

[Mitochondrial enzymes in circulating lymphocytes during hemosorption for experimental hypercholesterolemia].

1983 • 7 citations