Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Free radicals in biology and medicine

1991 • 17,840 citations

The Beaver Dam Eye Study

1992 • 1,362 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Invited Review: Estrogens effects on the brain: multiple sites and molecular mechanisms

2001 • 645 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Prevalence of Age-related Lens Opacities in a Population

1992 • 574 citations

Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women

1994 • 534 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Comparative binding affinity of estrogens and its relation to estrogenic potency

1969 • 335 citations

Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death

1999 • 294 citations

The epidemiology of cataract in Australia

1999 • 278 citations

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2001 • 239 citations

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1996 • 238 citations

The Content and Cost of Cataract Surgery

1993 • 223 citations

The inhibition of low-density lipoprotein oxidation by 17-β estradiol

1992 • 211 citations

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2001 • 203 citations

Propagation and immortalization of human lens epithelial cells in culture.

1994 • 196 citations

Incidence of Age-Related Cataract

1998 • 184 citations

Phenolic A ring requirement for the neuroprotective effects of steroids

1997 • 184 citations

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2001 • 177 citations

Lipid peroxidation in cataract of the human

1986 • 168 citations

The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease

1994 • 157 citations

Is There Evidence of an Estrogen Effect on Age-Related Lens Opacities?

1994 • 146 citations

Hormone Replacement Therapy, Reproductive Factors, and Cataract The Blue Mountains Eye Study

1997 • 136 citations

Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells

1997 • 133 citations

Estrogen Protects Lenses against Cataract Induced by Transforming Growth Factor-β (TGFβ)

1997 • 130 citations

Cell Death and Diseases of the Nervous System

1999 • 112 citations

The Nonfeminizing Enantiomer of 17β-Estradiol Exerts Protective Effects in Neuronal Cultures and a Rat Model of Cerebral Ischemia**This work was supported by NIH Grants AG-10485 (to J.W.S.) and GM- 47969 (to D.F.C.), U.S. Army Grant DAMD-17–99-1–9473 (to J.W.S.), and Apollo Biopharmaceutics, Inc. funding (to J.W.S. and D.F.C.).

2001 • 109 citations

A Novel, Synergistic Interaction Between 17 β-Estradiol and Glutathione in the Protection of Neurons against β-Amyloid 25–35-Induced Toxicity In Vitro

1998 • 104 citations

Hormone Replacement Therapy, Reproductive Factors, and the Incidence of Cataract and Cataract Surgery: : The Blue Mountains Eye Study

2002 • 101 citations

ATP Assay: Ability To Distinguish Cytostatic From Cytocidal Anticancer Drug Effects<xref ref-type="fn" rid="FN2">2</xref>

1986 • 87 citations

Stopped-flow investigation of antioxidant activity of estrogens in solution

1990 • 85 citations

Protective effects of estrogen in a rat model of age-related cataracts

1999 • 77 citations

Hormone Replacement Therapy and Lens Opacities

2001 • 67 citations

Radio-isotopic determination of hydrogen peroxide in aqueous humor and urine

1991 • 62 citations

Effects of estradiol-17α on nuclear occupancy of the estrogen receptor, stimulation of nuclear type II sites and uterine growth

1982 • 58 citations

Electrophoretic characterization of purified bovine, porcine, murine, rat, and human uterine estrogen receptors.

1985 • 54 citations

Estrogens and Estrogen‐Like Non‐Feminizing Compounds: Their Role in the Prevention and Treatment of Alzheimer's Disease

2000 • 51 citations

Assessment of mitochondrial membrane potential in situ using single potentiometric dyes and a novel fluorescence resonance energy transfer technique

2001 • 47 citations

Synthesis and Biological Evaluation of 17β-Alkoxyestra-1,3,5(10)-trienes as Potential Neuroprotectants Against Oxidative Stress

2000 • 36 citations

Estradiol attenuation of beta-amyloid-induced toxicity: a comparison o.

2000 • 35 citations

Tempol and deferoxamine protect cultured rabbit lens epithelial cells from H2O2 insult: insight into the mechanism of H2O2-induced injury.

1992 • 34 citations

Lens methionine sulfoxide reductase

1982 • 30 citations

An estrogen receptor repressor induces cataract formation in transgenic mice

2002 • 28 citations

Postmenopausal hormone use and lens opacities

2002 • 26 citations

A Population-Based Estimate of Cataract Prevalence: The Melbourne Visual Impairment Project Experience1

2015 • 26 citations

Effect Of Various Oestrogens On Cell Injury And Alteration Of Apical Transporters Induced By Tert-Butyl Hydroperoxide In Renal Proximal Tubule Cells

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Population-Based Case-Control Study of Cortical Cataract in the Noto Area, Japan1

2015 • 9 citations