Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression

Estrogen Actions in the Central Nervous System¹

1999 • 1,381 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

17β-Estradiol Enhances NMDA Receptor-Mediated EPSPs and Long-Term Potentiation

1999 • 505 citations

Mitochondrial calcium transport

1982 • 486 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1996 • 443 citations

Vectorial Chemistry and the Molecular Mechanics of Chemiosmotic Coupling: Power Transmission by Proticity

1976 • 431 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues

1978 • 402 citations

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration

1993 • 396 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Estrogen protects primary cortical neurons from glutamate toxicity

1996 • 329 citations

Impact of Progestins on Estrogen-Induced Neuroprotection: Synergy by Progesterone and 19-Norprogesterone and Antagonism by Medroxyprogesterone Acetate

2002 • 321 citations

Mitochondria and Na+/Ca2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons

1995 • 292 citations

The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus

2000 • 274 citations

Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

1996 • 238 citations

Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3‐nitroproprionic acid in SK‐N‐SH human neuroblastoma cells

2001 • 203 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

Cellular and Molecular Mechanisms of Estrogen Regulation of Memory Function and Neuroprotection Against Alzheimer's Disease: Recent Insights and Remaining Challenges

2001 • 177 citations

Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons

1996 • 169 citations

Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.

1997 • 169 citations

Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators

1997 • 149 citations

Estrogen-regulated developmental neuronal apoptosis is determined by estrogen receptor subtype and the Fas/Fas ligand system

2000 • 145 citations

The female sex hormone oestrogen as a neuroprotectant

1999 • 137 citations

Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway

2002 • 131 citations

Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1

1997 • 117 citations

Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

1999 • 112 citations

The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective

2000 • 107 citations

High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations

1999 • 89 citations

Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel.

2000 • 83 citations

Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus

2001 • 78 citations

Effect of Bcl-2 on oxidant-induced cell death and intracellular Ca²⁺mobilization

1998 • 64 citations

Opioid neurotransmission in the post-ictal analgesia: Involvement of μ1-opioid receptor

2001 • 38 citations

Blockade of mitochondrial Ca²⁺ uptake by mitochondrial inhibitors amplifies the glutamate‐induced calcium response in cultured cerebellar granule cells

1999 • 36 citations

Binding of Calcium by Liver Mitochondria of Rats Treated with Steroid Hormones

1966 • 33 citations

Binding of Calcium by Liver Mitochondria: An Effect of Steroid Hormones in Vitamin D-Depleted and Parathyroidectomized Rats

1967 • 30 citations