Postischemic Recovery of Contractile Function is Impaired in SOD2 ^+/− but Not SOD1 ^+/− Mouse Hearts

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Myocardial 'stunning' in man.

1992 • 531 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity

1985 • 384 citations

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

1989 • 381 citations

Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation

1999 • 366 citations

Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO

1987 • 357 citations

Overexpression of MnSOD Protects Against Myocardial Ischemia/reperfusion Injury in Transgenic Mice

1998 • 351 citations

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin

1999 • 332 citations

Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase

1998 • 328 citations

Oxygen-derived free radicals and myocardial reperfusion injury: An overview

1991 • 303 citations

Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice

1998 • 279 citations

Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury

1998 • 254 citations

Enzyme function of copper, zinc superoxide dismutase as a free radical generator.

1993 • 224 citations

Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.

1986 • 193 citations

Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1990 • 157 citations

Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.

1995 • 132 citations

The cardioprotective effect of Mn-superoxide dismutase is lost at high doses in the postischemic isolated rabbit heart

1990 • 132 citations

Targeted Disruption of the Mouse Sod I Gene Makes the Hearts Vulnerable to Ischemic Reperfusion Injury

2000 • 131 citations

Networking Antioxidants in the Isolated Rat Heart are Selectively Depleted by Ischemia-Reperfusion

1998 • 121 citations

Superoxide dismutase amplifies organismal sensitivity to ionizing radiation

1989 • 116 citations

Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector. Explanation for variations in paraquat resistance.

1990 • 112 citations

Gene Therapy With Extracellular Superoxide Dismutase Attenuates Myocardial Stunning in Conscious Rabbits

1998 • 109 citations

Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

1996 • 106 citations

Alterations in cardiac membrane Ca2+ transport during oxidative stress

1990 • 94 citations

Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses

1992 • 71 citations

Role of H2O2 in changing ß-adrenoceptor and adenylyl cyclase in ischemia-reperfused hearts

1998 • 36 citations

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1998 • 31 citations

Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization.

1993 • 16 citations