Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

1992 • 2,655 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

1999 • 619 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.

1996 • 511 citations

Localization of Apoptotic Macrophages at the Site of Plaque Rupture in Sudden Coronary Death

2000 • 360 citations

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

1999 • 314 citations

Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol

1995 • 258 citations

Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release

2000 • 246 citations

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

1995 • 238 citations

Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages.

1990 • 231 citations

Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035.

1984 • 230 citations

Elimination of Cholesterol in Macrophages and Endothelial Cells by the Sterol 27-Hydroxylase Mechanism

1997 • 228 citations

Glutathione is implied in the control of 7‐ketocholesterol‐induced apoptosis, which is associated with radical oxygen species production

1998 • 215 citations

Characterization and Comparison of the Mode of Cell Death, Apoptosis Versus Necrosis, Induced by 7β-Hydroxycholesterol and 7-Ketocholesterol in the Cells of the Vascular Wall

1999 • 196 citations

Chemical composition and physical state of lipid deposits in atherosclerosis

1985 • 192 citations

Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis.

1984 • 191 citations

Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway

2000 • 183 citations

Immunohistochemical localization of heat shock protein-70 in normal-appearing and atherosclerotic specimens of human arteries.

1990 • 178 citations

Assessment of Caspase Activities in Intact Apoptotic Thymocytes Using Cell-Permeable Fluorogenic Caspase Substrates

2000 • 164 citations

Effects of Intracellular Free Cholesterol Accumulation on Macrophage Viability

1998 • 163 citations

Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis

2000 • 134 citations

Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression.

1983 • 127 citations

The role of macrophages in atherogenesis

1993 • 121 citations

Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester.

1979 • 115 citations

Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis

1996 • 110 citations

Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase

1994 • 102 citations

p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism

2000 • 102 citations

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

1996 • 100 citations

Cell death in atherosclerotic plaques

1996 • 93 citations

Bcl-xL Inhibits Cytochrome c Release but Not Mitochondrial Depolarization during the Activation of Multiple Death Pathways by Tumor Necrosis Factor-α

2000 • 57 citations

Cholesterol increase in mitochondria: its effect on inner-membrane functions, submitochondrial localization and ultrastructural morphology

1993 • 41 citations

Cholesterol enrichment of normal mitochondria invitro: A model system with properties of hepatoma mitochondria

1978 • 25 citations

Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1–314) transgenic mice

1999 • 18 citations

Effects of cholesterol on the kinetics of mitochondrial ATPase

1986 • 18 citations

Vermehrte Apoptose und Nekrose in koronaren Plaques bei instabiler Angina (Increased apoptosis and necrosis in coronary plaques with unstable angina)

1997 • 13 citations

3-m-bromoacetylamino benzoic acid ethyl ester: a new cancericidal agent that activates the apoptotic pathway through caspase-9

2000 • 11 citations