Mitochondrial toxicity of antiviral drugs

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 1,134 citations

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

1990 • 845 citations

INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

1988 • 773 citations

Molecular Targets for AIDS Therapy

1990 • 736 citations

mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.

1991 • 588 citations

Mitochondrial DNA sequence variation in human evolution and disease.

1994 • 526 citations

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1991 • 511 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy.

1990 • 456 citations

Clinical Pharmacology of 3'-Azido-2',3'-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides

1989 • 356 citations

Oxidative Phosphorylation Diseases

1990 • 338 citations

The development of mitochondrial medicine.

1994 • 296 citations

Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides

1991 • 289 citations

Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine

1989 • 270 citations

Dideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus Infection

1991 • 213 citations

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.

1992 • 209 citations

Acyclovir: Discovery, mechanism of action, and selectivity

1993 • 202 citations

Biochemical pharmacology of (+)- and (-)-2',3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents.

1992 • 199 citations

Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

1992 • 188 citations

Zidovudine myopathy: A distinctive disorder associated with mitochondrial dysfunction

1991 • 187 citations

Pathophysiology and management of HIV-associated hematologic disorders

1989 • 164 citations

Hepatomegaly with severe steatosis in HIV-seropositive patients

1993 • 157 citations

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine.

1994 • 156 citations

Lactic Acidosis Complicating the Acquired Immunodeficiency Syndrome

1993 • 138 citations

Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts.

1991 • 134 citations

Pathophysiology and management of HIV-associated hematologic disorders

1989 • 133 citations

Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model.

1991 • 125 citations

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.

1995 • 123 citations

Zidovudine‐induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage

1994 • 114 citations

Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′‐dideoxycytidine (ddc)

1989 • 112 citations

3′‐Azido‐3′‐deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells

1988 • 110 citations

Cardiac Structure and Function in Children with Human Immunodeficiency Virus Infection Treated with Zidovudine

1992 • 107 citations

Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS

1993 • 99 citations

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

1990 • 95 citations

The pc12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs

1991 • 83 citations

Mammalian DNA Polymerases .alpha., .beta., .gamma., .delta., and .epsilon. Incorporate Fialuridine (FIAU) Monophosphate into DNA and Are Inhibited Competitively by FIAU Triphosphate

1994 • 80 citations

Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies

1991 • 77 citations

Overview of Phase I Trials of 2′,3′-Dideoxyinosine (ddI) Conducted on Adult Patients

1990 • 67 citations

Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase.

1992 • 59 citations

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.

1994 • 57 citations

Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy

1994 • 55 citations

Overview of the Preclinical Development of an Antiretroviral Drug, 2′,3′-Dideoxyinosine

1990 • 55 citations

Mitochondrial schwannopathy and peripheral myelinopathy in a rabbit model of dideoxycytidine neurotoxicity.

1994 • 51 citations

Effect of L-carnitine on the zidovudine-induced destruction of human myotubes. Part I: L-carnitine prevents the myotoxicity of AZT in vitro.

1994 • 50 citations

³¹ P magnetic resonance spectroscopy suggests impaired mitochondrial function in AZT‐treated HIV‐infected patients

1992 • 45 citations

Partial cytochrome c oxidase deficiency and cytoplasmic bodies in patients with zidovudine myopathy

1991 • 43 citations

Effects of 2′‐fluorinated arabinosyl‐pyrimidine nucleosides on duck hepatitis B virus DNA level in serum and liver of chronically infected ducks

1992 • 41 citations

Dilated cardiomyopathy in a zidovudine-treated AIDS patient

1992 • 37 citations

Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells.

1994 • 32 citations

MEDICINE AND THE LAW

1994 • 30 citations

Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice

1990 • 20 citations

Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice

1990 • 19 citations

Drug Trial Deaths Deemed Unavoidable

1994 • 13 citations

Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus — HIV-1

1993 • 10 citations

Reversal of Azidothymidine-Induced Bone Marrow Suppression by 2′,3′-Dideoxythymidine as Studied by Hemopoietic Clonal Culture

1990 • 4 citations

US health agencies at odds over trial deaths

1994 • 3 citations

Amelioration of azidothymidine-induced erythroid toxicity by hemin and stem cell factor in immune-suppressed mice.

1994 • 3 citations

Reply

1994 • 1 citations

Deleted Work

1955 • 0 citations