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Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria

Data up to Jan 2025

Published2003
Citations213
References48

Total Citations Per Year

Abstract

References (48)

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

[44] Glutathione peroxidase

1981 • 2,990 citations

Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.

2000 • 2,864 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc 1 Complex

1998 • 1,214 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver

2001 • 971 citations

Glutathione: Metabolism and function

1978 • 971 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains

1992 • 772 citations

Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol

2003 • 682 citations

Spin trapping. Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones

1980 • 635 citations

Detection of catalase in rat heart mitochondria.

1991 • 556 citations

Peroxiredoxins

2002 • 555 citations

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

2001 • 521 citations

Glutathione metabolism and its role in hepatotoxicity

1991 • 495 citations

Untitled

1997 • 432 citations

Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation

2003 • 387 citations

Modulation of Mitochondrial Function by Hydrogen Peroxide

2001 • 374 citations

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

1995 • 339 citations

A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes

1984 • 322 citations

Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria

1980 • 273 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

The physiological consequences of glutathione variations

1992 • 200 citations

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α-induced apoptosis in cultured mouse hepatocytes

2002 • 182 citations

Relative contributions of heart mitochondria glutathione peroxidase and catalase to H2O2 detoxification in in vivo conditions

2002 • 155 citations

Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants

1997 • 136 citations

Myxothiazol Induces H2O2 Production from Mitochondrial Respiratory Chain

2001 • 133 citations

Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol.

1987 • 126 citations

Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol

2002 • 125 citations

Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding Site

1998 • 118 citations

Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney

1999 • 99 citations

The simultaneous determination of oxidized and reduced glutathiones in liver tissue by ion pairing reverse phase high performance liquid chromatography with a coulometric electrochemical detector

1989 • 90 citations

Oxygen, Gene Expression, and Cellular Function

1997 • 90 citations

The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions

2002 • 82 citations

The pathway of electron transfer in the dimeric QH2: Cytochromec oxidoreductase

1986 • 64 citations

Mitochondrial oxidative phosphorylation and intracellular glutathione compartmentation during rat liver regeneration

1995 • 63 citations

The chemistry and mechanics of ubihydroquinone oxidation at center P (Qo) of the cytochrome bc1 complex

1998 • 60 citations

Evidence for the existence of catalase in the matrix space of rat‐heart mitochondria

1978 • 56 citations

Pathways of hydrogen peroxide generation in guinea pig cerebral cortex mitochondria

1988 • 44 citations

Properties of mitochondria treated with 1-chloro-2,4-dinitrobenzene

1985 • 32 citations

Mathematical modelling of superoxide generation with the bc1 complex of mitochondria

1998 • 27 citations

Purification and determination of activity of mitochondrial cyanide-sensitive superoxide dismutase in rat tissue extract

2002 • 18 citations

The action of the glutathione transferase substrate, 1-chloro-2, 4-dinitrobenzene on synaptosomal glutathione content and the release of hydrogen peroxide

1990 • 11 citations

Mitochondrial oxidative phosphorylation and intracellular glutathione compartmentation during rat liver regeneration

1995 • 4 citations

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