Estrogen's Effects on Mitochondrial Gene Expression: Mechanisms and Potential Contributions to Estrogen Carcinogenesis

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Estrogen and the Risk of Breast Cancer

2001 • 1,081 citations

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

Molecular Mechanisms of Estrogen Carcinogenesis

1996 • 659 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

1997 • 611 citations

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

1995 • 532 citations

The Complete Primary Structure of Human Estrogen Receptor β (hERβ) and Its Heterodimerization with ER αin Vivoandin Vitro

1998 • 510 citations

Chapter 3: Endogenous Estrogens as Carcinogens Through Metabolic Activation

2000 • 396 citations

Oestrogen receptors – an overview

1999 • 383 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells

1999 • 371 citations

Estrogens and breast cancer

1996 • 343 citations

Cellular functions of plasma membrane estrogen receptors

2002 • 334 citations

Oestrogen exposure and breast cancer risk

2003 • 312 citations

Cloning of the human oestrogen receptor cDNA

1986 • 299 citations

Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens.

2000 • 292 citations

Stereospecific binding of estrogens in the rat uterus

1965 • 272 citations

Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7.

1995 • 272 citations

Mitochondrial localization of ERα and ERβ in human MCF7 cells

2004 • 264 citations

Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis

2003 • 239 citations

Plasma Membrane Estrogen Receptors Signal to Antiapoptosis in Breast Cancer

2000 • 224 citations

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.

1994 • 186 citations

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

2000 • 179 citations

Estrogen receptors in uterine plasma membrane

1979 • 178 citations

Mitochondrial genes as sites of primary action of steroid hormones

1996 • 177 citations

Estrogen receptors: structure, mechanisms and function.

2002 • 142 citations

Myocardial ischemia-reperfusion injury in estrogen receptor-α knockout and wild-type mice

2000 • 141 citations

Binding of MCF‐7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial dna estrogen response elements

2004 • 138 citations

Antibodies to the estrogen receptor‐α modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors

2000 • 129 citations

The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements

1995 • 129 citations

Linkage of Rapid Estrogen Action to MAPK Activation by ER -Shc Association and Shc Pathway Activation

2002 • 119 citations

Subcellular distribution of native estrogen receptor α and β isoforms in rabbit uterus and ovary

2001 • 113 citations

Localization of glucocorticoid hormone receptors in mitochondria of human cells

2000 • 106 citations

The Effects of Steroid Hormones on the Transcription of Genes Encoding Enzymes of Oxidative Phosphorylation

2003 • 103 citations

Membrane association of estrogen receptor α mediates estrogen effect on MAPK activation

2002 • 98 citations

Liver tumor promotion: Effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-?1 expression

1991 • 89 citations

Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect

1983 • 85 citations

Estrogen Induction of Cytochrome c Oxidase Subunit III in Rat Hippocampus

1992 • 84 citations

Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.

1998 • 82 citations

Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.

1982 • 80 citations

Estrogen Induces Accumulation of the Mitochondrial Ribonucleic Acid for Subunit II of Cytochrome Oxidase in Pituitary Tumor Cells

1988 • 79 citations

Import of the glucocorticoid receptor into rat liver mitochondria in vivo and in vitro

1993 • 78 citations

Catecholestrogens are MCF-7 cell estrogen receptor agonists

1993 • 78 citations

Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells

2003 • 73 citations

Metabolic and proliferative responses to estrogen by hepatocytes selected for plasma membrane binding‐sites specific for estradiol‐17β

1979 • 71 citations

Effect of Rodent Hepatocarcinogenic Peroxisome Proliferators on Fatty Acyl-CoA Oxidase, DNA Synthesis, and Apoptosis in Cultured Human and Rat Hepatocytes

1998 • 67 citations

Identification and characterization of membrane estrogen receptor from MCF7 estrogen-target cells

2001 • 67 citations

Effect of estrogen upon cyclic ADP ribose metabolism: β-Estradiol stimulates ADP ribosyl cyclase in rat uterus

1997 • 64 citations

The Mitochondrion as a Primary Site of Action of Glucocorticoids: Mitochondrial Nucleotide Sequences, Showing Similarity to Hormone Response Elements, Confer Dexamethasone Inducibility to Chimaeric Genes Transfected in LATK−Cells

1997 • 64 citations

Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol

1994 • 63 citations

Urinary endogenous sex hormone levels and the risk of postmenopausal breast cancer

2003 • 62 citations

Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate

1992 • 62 citations

The mitochondrial genome: a possible primary site of action of steroid hormones.

1990 • 62 citations

Electron microscopic visualization of membrane-mediated uptake and translocation of estrogen-BSA:colloidal gold by hep G2 cells

2000 • 60 citations

Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment

1999 • 60 citations

Enhanced Mitochondrial Gene Transcript, ATP, Bcl-2 Protein Levels, and Altered Glutathione Distribution in Ethinyl Estradiol-Treated Cultured Female Rat Hepatocytes

2003 • 59 citations

Differential cellular localization of estrogen receptor α in uterine and mammary cells

2001 • 58 citations

Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells

1998 • 57 citations

A Unified Mechanism in the Initiation of Cancer

2002 • 52 citations

Effects of dietary phytoestrogen on global myocardial ischemia-reperfusion injury in isolated female rat hearts

2001 • 46 citations

Catecholestrogens are agonists of estrogen receptor dependent gene expression in MCF-7 cells

1994 • 41 citations

Rapid Uptake and Binding of Estradiol-17β-6-(O-carboxymethyl)oxime:125I-labeled Bsa by Female Rat Liver1

1998 • 41 citations

SHORT COMMUNICATION: Identification of genes whose expression is altered during mitosuppression in livers of ethinyl estradiol-treated female rats

1996 • 37 citations

Estrogenic activity of estradiol and its metabolites in the ER‐CALUX assay with human T47D breast cells^Note

2001 • 37 citations

Inhibition of TGF-β-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes

2000 • 29 citations

Immunocytochemical Localization of the [³H]Estradiol-Binding Protein in Rat Pancreatic Acinar Cells

1989 • 27 citations

Hormonal regulation of hypothalamic gene expression: Identification of multiple novel estrogen induced genes

1994 • 18 citations

Recovery of hyperplastic responsiveness in rat liver after dosing with the peroxisome proliferator methylclofenapate

1991 • 9 citations