Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1998 • 1,494 citations

[10] Superoxide dismutase assays

1984 • 1,468 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Peroxidases in chemistry and biology

1990 • 1,039 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite

1997 • 778 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

1981 • 757 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Nitric oxide and mitochondrial respiration

1999 • 690 citations

Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

1996 • 583 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1998 • 506 citations

A Tale of Two Controversies

2002 • 484 citations

Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy

2003 • 453 citations

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

1998 • 444 citations

Mitochondria: a practical approach.

1987 • 412 citations

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1998 • 406 citations

Cytochrome c Nitration by Peroxynitrite

2000 • 348 citations

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

1998 • 342 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Mitochondria: A practical approach

1988 • 307 citations

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

1999 • 307 citations

Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle

1999 • 279 citations

Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes.

1998 • 263 citations

Eosinophil Peroxidase Nitrates Protein Tyrosyl Residues

1999 • 257 citations

Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

1999 • 229 citations

Lysosomal release of Cathepsin D precedes relocation of Cytochrome C and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress

1999 • 226 citations

Mechanism of Reaction of Myeloperoxidase with Nitrite

2000 • 221 citations

Molecular mechanisms in bioenergetics

1994 • 210 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

Reaction of Peroxynitrite with Mn-Superoxide Dismutase

2001 • 178 citations

Evidence for the Role of a Peroxidase Compound I-type Intermediate in the Oxidation of Glutathione, NADH, Ascorbate, and Dichlorofluorescin by Cytochrome c/H2O2

2003 • 158 citations

Apoptosis: checkpoint at the mitochondrial frontier

1999 • 152 citations

Cytochrome c-catalyzed oxidation of organic molecules by hydrogen peroxide

1991 • 146 citations

Nitrite as a Substrate and Inhibitor of Myeloperoxidase

2000 • 141 citations

ESR Spin-trapping of a Protein-derived Tyrosyl Radical from the Reaction of Cytochrome with Hydrogen Peroxide

1996 • 131 citations

Cytochrome c-catalyzed membrane lipid peroxidation by hydrogen peroxide

1991 • 129 citations

Protein Oxidation of Cytochrome c by Reactive Halogen Species Enhances Its Peroxidase Activity

2002 • 109 citations

Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway

2000 • 108 citations

Nitric Oxide and Peroxynitrite-Dependent Aconitase Inactivation and Iron-Regulatory Protein-1 Activation in Mammalian Fibroblasts

1998 • 97 citations

Mitochondrial tyrosine nitration precedes chronic allograft nephropathy

2001 • 95 citations

Relocalization of Cathepsin D and Cytochrome c Early in Apoptosis Revealed by Immunoelectron Microscopy

2001 • 92 citations

Nitration of the Low Molecular Weight Neurofilament Is Equivalent in Sporadic Amyotrophic Lateral Sclerosis and Control Cervical Spinal Cord

1998 • 78 citations

Expression of Inducible Nitric-oxide Synthase and Intracellular Protein Tyrosine Nitration in Vascular Smooth Muscle Cells

2003 • 72 citations

Serum concentrations of nitrite in patients with HIV-1 infection.

1996 • 71 citations

Early release and subsequent caspase‐mediated degradation of cytochrome c in apoptotic cerebellar granule cells

1999 • 69 citations

Roles of catalase and cytochrome C in hydroperoxide-dependent lipid peroxidation and chemiluminescence in rat heart and kidney mitochondria

1993 • 65 citations

The Role of Cytochrome c and Mitochondrial Catalase in Hydroperoxide-Induced Heart Mitochondrial Lipid Peroxidation

1993 • 62 citations

Characterization of Cytochrome c Free Radical Reactions with Peptides by Mass Spectrometry

1998 • 53 citations

Myoglobin-Catalyzed Tyrosine Nitration: No Need for Peroxynitrite

2001 • 49 citations

Acidic Fibroblast Growth Factor Enhances Peroxynitrite-Induced Apoptosis in Primary Murine Fibroblasts

1996 • 44 citations

Pulse radiolysis study of aqueous hydrogen cyanide and cyanide solutions

1974 • 43 citations

Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals

2001 • 41 citations

Coexistence of translocated cytochrome c and nitrated protein in neurons of the rat cerebral cortex after oxygen and glucose deprivation

2002 • 38 citations

Radiation chemistry of aqueous cyanide ion

1977 • 33 citations

Mitochondria, Oxygen and Reperfusion Damage

1991 • 22 citations