Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium

1999 • 690 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Oxygen free radicals and congestive heart failure.

1991 • 540 citations

Expression of Inducible Nitric Oxide Synthase in Human Heart Failure

1996 • 496 citations

Elevated Levels of 8-iso-Prostaglandin F _2α in Pericardial Fluid of Patients With Heart Failure

1998 • 446 citations

Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats.

1996 • 364 citations

Inhibition of Copper-Zinc Superoxide Dismutase Induces Cell Growth, Hypertrophic Phenotype, and Apoptosis in Neonatal Rat Cardiac Myocytes In Vitro

1999 • 279 citations

Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

1991 • 278 citations

Right and Left Myocardial Antioxidant Responses During Heart Failure Subsequent to Myocardial Infarction

1997 • 271 citations

Cellular metabolism of water-soluble nitroxides: Effect on rate of reduction of cell/nitroxide ratio, oxygen concentrations and permeability of nitroxides

1986 • 192 citations

Electron paramagnetic resonance measurements of free radicals in the intact beating heart: a technique for detection and characterization of free radicals in whole biological tissues.

1988 • 163 citations

Antioxidant changes in hypertrophied and failing guinea pig hearts

1994 • 160 citations

Spin Trapping of Superoxide Radicals and Peroxynitrite by 1-Hydroxy-3-carboxy-pyrrolidine and 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine and the Stability of Corresponding Nitroxyl Radicals Towards Biological Reductants

1997 • 136 citations

ESR measurement of free radicals in whole mice

1990 • 110 citations

Principles of the Metabolism of Nitroxides and Their Implications for Spin Trapping

1990 • 93 citations

Role of Myocyte Nitric Oxide in β-Adrenergic Hyporesponsiveness in Heart Failure

1997 • 87 citations

Antioxidant Activity of Nitroxide Radicals in Lipid Peroxidation of Rat Liver Microsomes

1993 • 82 citations

Amiodarone Protects Cardiac Myocytes Against Oxidative Injury by its Free Radical Scavenging Action

1999 • 74 citations

Metabolism of nitroxide spin labels in subcellular fraction of rat liver

1990 • 63 citations

In vivoEPR Measurement of Radical Reaction in Whole Mice – Influence of Inspired Oxygen and Ischemia–Reperfusion Injury on Nitroxide Reduction

1993 • 53 citations