Mechanisms of Cell Signaling by Nitric Oxide and Peroxynitrite: From Mitochondria to MAP Kinases

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient

1997 • 1,050 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Guanylate cyclase and the ⋅NO/cGMP signaling pathway

1999 • 998 citations

Persistent inhibition of cell respiration by nitric oxide: Crucial role ofS-nitrosylation of mitochondrial complex I and protective action of glutathione

1998 • 825 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Superoxide in Apoptosis

1998 • 773 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

1996 • 699 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Reactions between nitric oxide and haemoglobin under physiological conditions

1998 • 577 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

1997 • 527 citations

Nitric oxide and iron proteins

1999 • 506 citations

A Molecular Redox Switch on p21

1997 • 488 citations

The Simultaneous Generation of Superoxide and Nitric Oxide Can Initiate Lipid Peroxidation in Human Low Density Lipoprotein

1992 • 460 citations

Nitric Oxide as a Bifunctional Regulator of Apoptosis

1999 • 457 citations

Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

2000 • 445 citations

Signal transduction of eNOS activation

1999 • 444 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Nitric oxide as an antioxidant

1991 • 441 citations

The oxyhemoglobin reaction of nitric oxide

1999 • 418 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

Nitric oxide and lipid peroxidation

1999 • 364 citations

The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle

1998 • 357 citations

Why nitric oxide?

1992 • 350 citations

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

2000 • 326 citations

NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium

1996 • 326 citations

Nitric Oxide Inhibits Fas-induced Apoptosis

1997 • 317 citations

Factors Determining the Selectivity of Protein Tyrosine Nitration

1999 • 313 citations

Carbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration

1996 • 302 citations

Upregulation of Superoxide Dismutase and Nitric Oxide Synthase Mediates the Apoptosis-Suppressive Effects of Shear Stress on Endothelial Cells

1999 • 299 citations

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1997 • 297 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Nitric oxide–an endothelial cell survival factor

1999 • 281 citations

Nitric Oxide Regulation of Tissue Free Radical Injury

1996 • 278 citations

Reversible Binding and Inhibition of Catalase by Nitric Oxide

1995 • 277 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation

2000 • 257 citations

Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.

1994 • 255 citations

Nitric Oxide Inhibition of Lipid Peroxidation: Kinetics of Reaction with Lipid Peroxyl Radicals and Comparison with α-Tocopherol

1997 • 252 citations

Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle

1996 • 209 citations

Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules

1998 • 208 citations

The formation of nitric oxide donors from peroxynitrite

1995 • 203 citations

A New Pathway of Nitric Oxide/Cyclic GMP Signaling InvolvingS-Nitrosoglutathione

1998 • 199 citations

A Role for Reactive Oxygen Species in Endothelial Cell Anoikis

1999 • 195 citations

Nitric Oxide Modulates the Catalytic Activity of Myeloperoxidase

2000 • 195 citations

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

1999 • 194 citations

The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol

1999 • 183 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

Carbon Dioxide: Physiological Catalyst for Peroxynitrite-Mediated Cellular Damage or Cellular Protectant?

1996 • 176 citations

Membrane-Linked Systems Preventing Superoxide Formation

1997 • 162 citations

Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH₂-terminal kinase

1999 • 155 citations

Contractile activity-induced adaptations in the mitochondrial protein import system

1998 • 145 citations

Physiology and pathophysiology of nitric oxide.

1996 • 141 citations

Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin

2000 • 141 citations

Electron Paramagnetic Resonance and Oxygen Binding Studies of α-Nitrosyl Hemoglobin

1998 • 140 citations

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ‐glutamylcysteine synthetase and γ‐glutamyl transpeptidase

1999 • 135 citations

Biochemical Characterization of HumanS-Nitrosohemoglobin

1999 • 135 citations

Nitric Oxide-inducible Expression of Heme Oxygenase-1 in Human Cells

2000 • 134 citations

Reduction of Ferrylmyoglobin and Ferrylhemoglobin by Nitric Oxide: A Protective Mechanism against Ferryl Hemoprotein-Induced Oxidations

1995 • 125 citations

Nitric Oxide-Dependent Induction of Glutathione Synthesis through Increased Expression of γ-Glutamylcysteine Synthetase

1998 • 125 citations

Nitric Oxide Down-regulates MKP-3 mRNA Levels

2000 • 123 citations

Peroxynitrite and Brain Mitochondria: Evidence for Increased Proton Leak

1998 • 121 citations

Biochemical Characterization ofS-Nitrosohemoglobin

1999 • 118 citations

Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide

2000 • 118 citations

Nitric Oxide-Induced Cytotoxicity: Involvement of Cellular Resistance to Oxidative Stress and the Role of Glutathione in Protection

1995 • 117 citations

Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis

2000 • 115 citations

Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits

1999 • 113 citations

Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide

2000 • 108 citations

Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury

1998 • 107 citations

Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide

1993 • 103 citations

Transfection of Inducible Nitric Oxide Synthase Gene Causes Apoptosis in Vascular Smooth Muscle Cells

1998 • 103 citations

ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats

1994 • 98 citations

Thiol Dependence of Nitric Oxide Synthase

1995 • 96 citations

Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells

1993 • 95 citations

Dissociation of Nitric Oxide from Soluble Guanylate Cyclase

1997 • 95 citations

15-Lipoxygenase Catalytically Consumes Nitric Oxide and Impairs Activation of Guanylate Cyclase

1999 • 88 citations

A Sp1 Binding Site of the Tumor Necrosis Factor α Promoter Functions as a Nitric Oxide Response Element

1999 • 86 citations

Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels

1999 • 85 citations

Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

2000 • 80 citations

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

1999 • 80 citations

The Effect of Nitric Oxide Release Rates on the Oxidation of Human Low Density Lipoprotein

1997 • 78 citations

Hypercholesterolemia Impairs a Detoxification Mechanism Against Peroxynitrite and Renders the Vascular Tissue More Susceptible to Oxidative Injury

1997 • 76 citations

Nitrogen Monoxide Activates Iron Regulatory Protein 1 RNA-Binding Activity by Two Possible Mechanisms: Effect on the [4Fe-4S] Cluster and Iron Mobilization from Cells

2000 • 74 citations

Modulation of Expression of Endothelial Nitric Oxide Synthase by Nordihydroguaiaretic Acid, a Phenolic Antioxidant in Cultured Endothelial Cells

1999 • 69 citations

Effects of S-Nitrosation on Oxygen Binding by Normal and Sickle Cell Hemoglobin

1999 • 66 citations

d-α-tocopherol control of cell proliferation

1993 • 65 citations

Intact Mitochondrial Electron Transport Function is Essential for Signalling by Hydrogen Peroxide in Cardiac Myocytes

2000 • 64 citations

The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism

2000 • 57 citations

The reactions of copper proteins with nitric oxide

1999 • 52 citations

Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation

1998 • 51 citations

Nitric oxide and hemoglobin interactions in the vasculature

1999 • 49 citations

Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties.

1993 • 36 citations

Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells

2000 • 30 citations

A nitric oxide‐releasing reagent, S‐nitroso‐N‐acetylpenicillamine, enhances the expression of superoxide dismutases mRNA in the murine macrophage cell line RAW264‐7

1997 • 22 citations

The protective action of nitric oxide against membrane damage induced by myoglobin radicals

1990 • 19 citations

Down-regulation of renal glutathione synthesis by systemic nitric oxide synthesis inhibition in spontaneously hypertensive rats

2000 • 19 citations

Nitric oxide releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of manganese superoxide dismutase mRNA in rat vascular smooth muscle cells

1996 • 12 citations