Mitochondrial Function Is Involved in LDL Oxidation Mediated by Human Cultured Endothelial Cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Superoxide Dismutase

1969 • 12,578 citations

Beyond Cholesterol

1989 • 6,533 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Lipid peroxides and human diseases

1987 • 1,358 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Biochemical structural and functional properties of oxidized low-density lipoprotein

1990 • 536 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.

1993 • 486 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Regulation of antioxidant enzymes ¹

1992 • 465 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life

1990 • 408 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages

1993 • 311 citations

Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.

1993 • 295 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Mechanisms of cell death

1989 • 237 citations

Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin.

1989 • 231 citations

Role of superoxide in endothelial-cell modification of low-density lipoproteins

1988 • 228 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation

1987 • 168 citations

The action of defined oxygen-centred free radicals on human low-density lipoprotein

1989 • 167 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium‐dependent pathways in lymphoblastoid cells

1994 • 120 citations

Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis

1996 • 115 citations

A fluorescence NK assay using flow cytometry

1986 • 114 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Further evidence that lucigenin-derived chemiluminescence monitors mitochondrial superoxide generation in rat alveolar macrophages

1994 • 95 citations

The role of altered lipoproteins in the pathogenesis of atherosclerosis

1987 • 94 citations

The oxidative modification of low density lipoprotein by human lymphocytes

1992 • 74 citations

Rapid preparative isolation of concentrated low density lipoproteins and of lipoprotein-deficient serum using vertical rotor gradient ultracentrifugation.

1985 • 70 citations

Cellular mechanisms for the oxidative modification of lipoproteins

1994 • 40 citations

Protection by Ca²⁺ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized low density lipoprotein to cultured lymphoid cells

1992 • 32 citations

Mitochondrial membrane potential monitored in situ within isolated guinea pig brown adipocytes by a styryl pyridinium fluorescent indicator

1984 • 30 citations

New pathogenetic hypothesis for Wolman disease: possible role of oxidized low-density lipoproteins in adrenal necrosis and calcification

1994 • 22 citations