The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE

1997 • 3,171 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Identification of Renox, an NAD(P)H oxidase in kidney

2000 • 824 citations

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

2001 • 794 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family

2000 • 611 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

2001 • 598 citations

A Plant Homolog of the Neutrophil NADPH Oxidase gp91^phox Subunit Gene Encodes a Plasma Membrane Protein with Ca²⁺ Binding Motifs

1998 • 590 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Phagocytosis and innate immunity

2002 • 579 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

1986 • 551 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Atomic Structure of Ferredoxin-NADP ⁺ Reductase: Prototype for a Structurally Novel Flavoenzyme Family

1991 • 532 citations

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

2001 • 531 citations

Localization of hydrogen peroxide accumulation during the hypersensitive reaction of lettuce cells to Pseudomonas syringae pv phaseolicola.

1997 • 522 citations

A Novel Superoxide-producing NAD(P)H Oxidase in Kidney

2001 • 508 citations

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

2001 • 478 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Reactive oxygen generated by Nox1 triggers the angiogenic switch

2002 • 473 citations

Oxygen sensing in airway chemoreceptors

1993 • 467 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells.

1991 • 448 citations

Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

1999 • 445 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Function of the oxidative burst in hypersensitive disease resistance.

1995 • 417 citations

Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91^phox)

1998 • 415 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

2001 • 373 citations

Regulation of phospholipase D

1999 • 369 citations

Novel homologs of gp91phox

2000 • 356 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

2000 • 335 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors

1990 • 323 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

2001 • 300 citations

Structure of the TPR Domain of p67phox in Complex with Rac·GTP

2000 • 300 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

A Mammalian H ⁺ Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1

2000 • 295 citations

The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b−245

1987 • 292 citations

Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis

2001 • 286 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

2002 • 281 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate

2001 • 273 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA

1990 • 254 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

The enzymic reduction and kinetics of oxidation of cytochrome b.245 of neutrophils

1982 • 247 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p47 as Determined by Two-dimensional Phosphopeptide Mapping

1996 • 241 citations

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91- phox and p22- phox in Endothelial Cells

2000 • 235 citations

Arachidonic Acid and Phosphorylation Synergistically Induce a Conformational Change of p47 to Activate the Phagocyte NADPH Oxidase

2000 • 235 citations

Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase

1999 • 230 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Chronic granulomatous disease

1994 • 223 citations

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 221 citations

A New Superoxide-generating Oxidase in Murine Osteoclasts

2001 • 218 citations

Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase

1996 • 209 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

NADPH oxidase of neutrophils

1996 • 208 citations

Electron currents generated by the human phagocyte NADPH oxidase

1998 • 206 citations

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways

2001 • 202 citations

Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase

1998 • 199 citations

Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body

1990 • 199 citations

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

2000 • 198 citations

The Respiratory Burst Oxidase

1992 • 198 citations

Gp91 ^phox is the heme binding subunit of the superoxide-generating NADPH oxidase

1998 • 198 citations

The p67 Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochromeb 558

1999 • 194 citations

NADPH oxidase is an O ₂ sensor in airway chemoreceptors: Evidence from K ⁺ current modulation in wild-type and oxidase-deficient mice

2000 • 194 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

The PX domain: a new phosphoinositide-binding module

2002 • 184 citations

The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

1995 • 184 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Characterization of ThOX Proteins as Components of the Thyroid H2O2-Generating System

2002 • 182 citations

Signaling pathways in phagocytosis

1999 • 178 citations

PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 Expression

1998 • 178 citations

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes

2001 • 178 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Activation of the Neutrophil Respiratory Burst Oxidase

1999 • 174 citations

Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

1998 • 173 citations

Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils

1993 • 170 citations

The effect of the NADPH oxidase inhibitor diphenyleneiodonium on aerobic and anaerobic microbicidal activities of human neutrophils

1988 • 167 citations

Solution structure of the PX domain, a target of the SH3 domain.

2001 • 165 citations

Processing and Maturation of Flavocytochromeb 558 Include Incorporation of Heme as a Prerequisite for Heterodimer Assembly

2000 • 163 citations

Topological Mapping of Neutrophil Cytochrome b Epitopes with Phage-display Libraries

1995 • 162 citations

An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

1994 • 160 citations

The Two Calcium-binding Proteins, S100A8 and S100A9, Are Involved in the Metabolism of Arachidonic acid in Human Neutrophils

1999 • 159 citations

NADPH Oxidase Activity Is Independent of p47

1996 • 154 citations

Cytosolic Phox proteins interact with and regulate the assembly of coronin in neutrophils

1997 • 152 citations

Architecture of the p40-p47-p67 Complex in the Resting State of the NADPH Oxidase

2002 • 152 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

The Cytosolic Component p47 Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

1996 • 150 citations

Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries.

1995 • 148 citations

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1994 • 148 citations

NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells

2000 • 148 citations

Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells.

1991 • 146 citations

The FRE1 Ferric Reductase of Is a Cytochrome Similar to That of NADPH Oxidase

1996 • 146 citations

Phoxy Lipids

2001 • 145 citations

Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils

1992 • 145 citations

Modular components of phagocytosis

1999 • 142 citations

Activation of p47 , a Cytosolic Subunit of the Leukocyte NADPH Oxidase

1998 • 141 citations

Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67 ^PHOX and cytochrome b ₅₅₈ II

2002 • 140 citations

Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines.

1989 • 140 citations

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

1996 • 138 citations

Identification of a Functional Leukocyte-Type NADPH Oxidase in Human Endothelial Cells : A Potential Atherogenic Source of Reactive Oxygen Species

1999 • 138 citations

Plant and human neutrophil oxidative burst complexes contain immunologically related proteins

1996 • 137 citations

Rac Binding to p67

1997 • 135 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

Enhanced Host Defense After Gene Transfer in the Murine p47phox-Deficient Model of Chronic Granulomatous Disease

1997 • 133 citations

B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chediak-Higashi syndrome.

1984 • 132 citations

Targeting of Rac1 to the Phagocyte Membrane Is Sufficient for the Induction of NADPH Oxidase Assembly

2000 • 131 citations

Identification of intracellular sites of superoxide production in stimulated neutrophils

1998 • 131 citations

The Respiratory Burst Oxidase and the Molecular Genetics of Chronic Granulomatous Disease

1993 • 130 citations

Oxidation-Reduction Properties of Flavodoxin from Peptostreptococcus elsdenii

1969 • 128 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH

1985 • 126 citations

A structural model for the nucleotide binding domains of the flavocytochrome b_–245 β‐chain

1993 • 124 citations

Assembly of the Human Neutrophil NADPH Oxidase Involves Binding of p67 and Flavocytochrome to a Common Functional Domain in p47

1996 • 124 citations

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease

1997 • 124 citations

Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system

2002 • 122 citations

Inhibition of Rap1A Binding to Cytochrome b ₅₅₈ of NADPH Oxidase by Phosphorylation of Rap1A

1991 • 120 citations

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

1992 • 120 citations

The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct

1993 • 119 citations

Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.

1991 • 119 citations

Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein

1992 • 118 citations

Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.

1996 • 116 citations

Membrane Association of Rac Is Required for High Activity of the Respiratory Burst Oxidase

1996 • 116 citations

Repressor Activity of CCAAT Displacement Protein in HL-60 Myeloid Leukemia Cells

1995 • 115 citations

Rac Activation Induces NADPH Oxidase Activity in Transgenic COS Cells, and the Level of Superoxide Production Is Exchange Factor-dependent

2002 • 115 citations

Molecular Genetics of Chronic Granulomatous Disease

1989 • 114 citations

Cytochrome b−245 of the Neutrophil Superoxide-generating System Contains Two Nonidentical Hemes

1995 • 114 citations

Recombination events between the p47-phoxgene and its highly homologous pseudogenes are the main cause of autosomal recessive chronic granulomatous disease

2000 • 113 citations

p40 Down-regulates NADPH Oxidase Activity through Interactions with Its SH3 Domain

1997 • 113 citations

The p40 and p47 PX Domains of NADPH Oxidase Target Cell Membranes via Direct and Indirect Recruitment by Phosphoinositides

2002 • 110 citations

Topology of cytochrome b558 in neutrophil membrane analyzed by anti-peptide antibodies and proteolysis.

1992 • 110 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

Selective Role for β-Protein Kinase C in Signaling for O⨪2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells

1998 • 110 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 109 citations

Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation

1995 • 109 citations

p40 Is Phosphorylated on Threonine 154 and Serine 315 during Activation of the Phagocyte NADPH Oxidase

1998 • 109 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

Role of p67-phox SH3 domains in assembly of the NADPH oxidase system.

1994 • 106 citations

Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.

1995 • 106 citations

A Noninvasive Fluorimetric Procedure for Measurement of Membrane Potential

1999 • 106 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

1995 • 104 citations

The NADPH oxidase complex of phagocytic leukocytes: a biochemical and cytochemical view

1995 • 103 citations

PU.1 as an essential activator for the expression of gp91^phoxgene in human peripheral neutrophils, monocytes, and B lymphocytes

1998 • 103 citations

Cytochrome b-245 from human neutrophils is a glycoprotein

1985 • 103 citations

Structure and Function of Leukocyte Chemoattractant Receptors

1997 • 102 citations

Heme-ligating Histidines in Flavocytochromeb 558

2001 • 102 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

The Heme Component of the Neutrophil NADPH Oxidase Complex Is a Target for Aryliodonium Compounds

1999 • 101 citations

Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 100 citations

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

1997 • 100 citations

The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig.

1988 • 100 citations

Generation of Superoxide by purified and relipidated cytochrome b₅₅₉ in the absence of cytosolic activators

1993 • 99 citations

Analysis of glycosylation sites on gp91phox, the flavocytochrome of the NADPH oxidase, by site-directed mutagenesis and translation in vitro

1997 • 99 citations

Activation of the Small GTPase Rap1 in Human Neutrophils

1998 • 98 citations

A novel protein kinase target for the lipid second messenger phosphatidic acid

1999 • 97 citations

Interactions of granulocyte-macrophage colony-stimulating factor (CSF), granulocyte CSF, and tumor necrosis factor alpha in the priming of the neutrophil respiratory burst

1992 • 96 citations

Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 • 96 citations

Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox.

1996 • 96 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

A Heterocomplex Formed by the Calcium-binding Proteins MRP8 (S100A8) and MRP14 (S100A9) Binds Unsaturated Fatty Acids with High Affinity

1997 • 94 citations

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

1995 • 93 citations

Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils

1986 • 92 citations

Mechanism of NADPH Oxidase Activation by the Rac/Rho-GDI Complex

2001 • 92 citations

Complete and Reversible Inhibition of NADPH Oxidase in Human Neutrophils by Phenylarsine Oxide at a Step Distal to Membrane Translocation of the Enzyme Subunits

1995 • 91 citations

Specificity of p47^phox SH3 Domain Interactions in NADPH Oxidase Assembly and Activation

1997 • 91 citations

Electron spin resonance studies on a flavoprotein in neutrophil plasma membranes. Redox potentials of the flavin and its participation in NADPH oxidase.

1986 • 89 citations

Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox

1996 • 89 citations

The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.

1990 • 89 citations

Phosphorylation of p22 Is Mediated by Phospholipase D-dependent and -independent Mechanisms

2000 • 88 citations

Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate

1979 • 88 citations

The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox.

1994 • 86 citations

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

1998 • 84 citations

Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in theNCF-1 pseudogenes

2001 • 84 citations

The Active N-terminal Region of p67

2001 • 83 citations

Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils

1999 • 83 citations

Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous Disease

1999 • 82 citations

The two redox potentials for oxygen reduction to superoxide

1987 • 82 citations

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils

1995 • 80 citations

Mapping of Functional Domains in the p22 Subunit of Flavocytochrome b 559 Participating in the Assembly of the NADPH Oxidase Complex by “Peptide Walking”

2002 • 80 citations

The PC motif : a novel and evolutionarily conserved sequence involved in interaction between p40 ^phox and p67^phox, SH3 domain‐containing cytosolic factors of the phagocyte NADPH oxidase

1998 • 80 citations

Different Subcellular Localization of Cytochrome b and the Dormant NADPH-Oxidase in Neutrophils and Macrophages: Effect on the Production of Reactive Oxygen Species during Phagocytosis

1995 • 79 citations

The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox

1997 • 79 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 78 citations

Direct evidence for interaction between COOH-terminal regions of cytochrome b558 subunits and cytosolic 47-kDa protein during activation of an O(2-)-generating system in neutrophils.

1992 • 78 citations

Functional modules and expression of mouse p40 ^phox and p67^phox, SH3‐domain‐containing proteins involved in the phagocyte NADPH oxidase complex

1998 • 77 citations

p40phox participates in the activation of NADPH oxidase by increasing the affinity of p47phox for flavocytochrome b558

2000 • 76 citations

Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex

1996 • 76 citations

The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain

2001 • 74 citations

Biosynthesis of Flavocytochrome b 558

1999 • 74 citations

Evaluation of the expression of NADPH oxidase components during maturation of HL-60 cells to neutrophil lineage

2000 • 74 citations

The respiratory burst of bovine neutrophilis

1985 • 73 citations

A Prenylated p67 -Rac1 Chimera Elicits NADPH-dependent Superoxide Production by Phagocyte Membranes in the Absence of an Activator and of p47

2002 • 73 citations

PU.1 Is Essential for p47 Promoter Activity in Myeloid Cells

1997 • 73 citations

Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein

1991 • 73 citations

P67-phox-Mediated NADPH Oxidase Assembly: Imaging of Cytochrome b₅₅₈ Liposomes by Atomic Force Microscopy

2000 • 72 citations

Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558.

1994 • 72 citations

The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils

2002 • 72 citations

Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils.

1994 • 70 citations

The NADPH-oxidase-associated H+ channel is opened by arachidonate

1992 • 69 citations

Thyroid Oxidase (THOX2) Gene Expression in the Rat Thyroid Cell Line FRTL-5

2000 • 68 citations

The gp91 Component of NADPH Oxidase Is Not the Voltage-gated Proton Channel in Phagocytes, but It Helps

2001 • 67 citations

Phage Display Epitope Mapping of Human Neutrophil Flavocytochromeb 558

2001 • 67 citations

Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL-60) cell line

1982 • 67 citations

p22-phox-deficient chronic granulomatous disease: reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox

1994 • 67 citations

Superoxide production by cytochrome b₅₅₉

1994 • 66 citations

A Variant X-linked Chronic Granulomatous Disease Patient (X91+) with Partially Functional Cytochrome b

1995 • 66 citations

Electron Transfer Across the O₂^- Generating Flavocytochrome b of Neutrophils. Evidence for a Transition from a Low-Spin State to a High-Spin State of the Heme Iron Component

1996 • 65 citations

Stoichiometry of p22-phox and gp91-phox in phagocyte cytochrome b558

1995 • 65 citations

Cloning of murine gp91phox cDNA and functional expression in a human X- linked chronic granulomatous disease cell line

1996 • 65 citations

The heterodimer of the Ca²⁺‐binding proteins MRP8 and MRP14 binds arachidonic acid

1997 • 64 citations

" Peptide Walking" Is a Novel Method for Mapping Functional Domains in Proteins

1995 • 63 citations

Activation of the Superoxide-Generating NADPH Oxidase by Chimeric Proteins Consisting of Segments of the Cytosolic Component p67^phoxand the Small GTPase Rac1

2001 • 62 citations

Heme Histidine Ligands within gp91 Modulate Proton Conduction by the Phagocyte NADPH Oxidase

2001 • 61 citations

Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.

1994 • 60 citations

Mutational Analysis of Novel Effector Domains in Rac1 Involved in the Activation of Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase

1998 • 60 citations

Complementation of NADPH oxidase in p67‐phox‐deficient CGD patients

2000 • 59 citations

Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro

1997 • 58 citations

The Mechanism of Electron Donation to Molecular Oxygen by Phagocytic Cytochrome b558

1995 • 57 citations

Essential Requirement of Cytosolic Phospholipase A2for Activation of the H+ Channel in Phagocyte-like Cells

1999 • 57 citations

Role of Histidines Identified by Mutagenesis in the NADPH Oxidase-associated H+ Channel

1998 • 56 citations

Activation of O₂⁻‐generating oxidase in an heterologous cell‐free system derived from Epstein‐Barr‐virus‐transformed human B lymphocytes and bovine neutrophils

1991 • 56 citations

Pyridine and imidazole reversibly inhibit the respiratory burst in porcine and human neutrophils: Evidence for the involvement of cytochrome in the reaction

1985 • 55 citations

Antibody Imprint of a Membrane Protein Surface

1998 • 54 citations

Direct Interaction of Actin with p47phox of Neutrophil NADPH Oxidase

2000 • 52 citations

Cloning and sequencing of the bovine flavocytochrome b subunit proteins, gp91-phox and p22-phox: comparison with other known flavocytochrome b sequences

1998 • 52 citations

Topological organization of the cytosolic activating complex of the superoxide-generating NADPH-oxidase. Pinpointing the sites of interaction between p47phox, p67phox and p40phox using the two-hybrid system

1996 • 51 citations

Mutation at Histidine 338 of gp91 Depletes FAD and Affects Expression of Cytochrome b 558 of the Human NADPH Oxidase

1998 • 51 citations

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte–macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

1999 • 51 citations

Phosphorylation of the leucocyte NADPH oxidase subunit p47phox by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity

2001 • 49 citations

Examination of the oxidase function of the b-type cytochrome in human polymorphonuclear leucocytes

1984 • 49 citations

The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.

1996 • 49 citations

Mapping of Functional Domains in p47 Involved in the Activation of NADPH Oxidase by “Peptide Walking”

1998 • 49 citations

The 40‐kDa Component of the Phagocyte NADPH Oxidase (p40phox) is Phosphorylated during Activation in Differentiated HL60 Cells

1997 • 49 citations

Ras effector-homolog region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex

1994 • 48 citations

Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.

1994 • 47 citations

Critical assessment of the presence of an NADPH binding site on neutrophil cytochrome b558 by photoaffinity and immunochemical labeling

1993 • 47 citations

Rac1 Disrupts p67phox/p40phox Binding: A Novel Role for Rac in NADPH Oxidase Activation

1999 • 46 citations

Phenylarsine oxide as an inhibitor of the activation of the neutrophil NADPH oxidase

1998 • 46 citations

Mutagenesis of an Arginine- and Lysine-rich Domain in the gp91 Subunit of the Phagocyte NADPH-oxidase Flavocytochromeb 558

1999 • 45 citations

Properties of the superoxide-generating oxidase of B-lymphocyte cell lines. Determination of Michaelis parameters

1989 • 45 citations

Probing the Role of the Carboxyl Terminus of the gp91 Subunit of Neutrophil Flavocytochromeb 558 using Site-directed Mutagenesis

1998 • 44 citations

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233

1999 • 44 citations

PU.1 and hematopoiesis: Lessons learned from gene targeting experiments

1998 • 43 citations

Fused p47 and p67 Truncations Efficiently Reconstitute NADPH Oxidase with Higher Activity and Stability Than the Individual Components

2001 • 43 citations

Photoaffinity Labeling and Photoinactivation of the O2--Generating Oxidase of Neutrophils by an Azido Derivative of FAD

1995 • 42 citations

Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase

1989 • 42 citations

Reconstitution of Flavin-depleted Neutrophil Flavocytochrome b558 with 8-Mercapto-FAD and Characterization of the Flavin-reconstituted Enzyme

1995 • 40 citations

A Fusion Protein between Rac and p67^phox (1−210) Reconstitutes NADPH Oxidase with Higher Activity and Stability than the Individual Components

2001 • 39 citations

Asparagine-linked glycosylation of cytochrome b558 large subunit varies in different human phagocytic cells.

1989 • 37 citations

Evidence for participation of vicinal dithiols in the activation sequence of the respiratory burst of human neutrophils

1995 • 36 citations

Kinetic Study of the Activation of the Neutrophil NADPH Oxidase by Arachidonic Acid. Antagonistic Effects of Arachidonic Acid and Phenylarsine Oxide

1999 • 36 citations

Structure of human phagocyte cytochrome b and its relationship to microbicidal superoxide production.

1995 • 35 citations

NADPH oxidase of Epstein–Barr‐virus immortalized B lymphocytes.

2001 • 34 citations

Tyrosine kinases in neutrophils

1999 • 33 citations

Detection of gp91-phox precursor protein in B-cell lines from patients with X-linked chronic granulomatous disease as an indicator for mutations impairing cytochrome b558 biosynthesis

1996 • 31 citations

Characterization of membrane-localized and cytosolic Rac-GTPase-activating proteins in human neutrophil granulocytes: contribution to the regulation of NADPH oxidase

2001 • 30 citations

Binding of Nicotinamide Adenine Dinucleotide Phosphate to the Tetratricopeptide Repeat Domains at the N-Terminus of p67^PHOX, a Subunit of the Leukocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase

2000 • 30 citations

Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D

2002 • 29 citations

Purification and characterization of an oxidase activating factor of 63-kilodaltons from bovine neutrophils

1991 • 29 citations

Small Angle Neutron Scattering and Gel Filtration Analyses of Neutrophil NADPH Oxidase Cytosolic Factors Highlight the Role of the C-Terminal End of p47^phox in the Association with p40^phox

2001 • 29 citations

A Phenylarsine Oxide-Binding Protein of Neutrophil Cytosol, Which Belongs to the S100 Family, Potentiates NADPH Oxidase Activation

2001 • 29 citations

EPR signals of cytochrome b558 purified from porcine neutrophils.

1992 • 28 citations

Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients.

1998 • 27 citations

Transcriptional Regulation of the p67 Gene

2001 • 27 citations

Hematologically Important Mutations: X-Linked Chronic Granulomatous Disease

1996 • 27 citations

Affinity-Labeling of an NADPH-Binding Site on the Heavy Subunit of Flavocytochrome b558 in Particulate NADPH Oxidase from Activated Human Neutrophils

1993 • 26 citations

The O2− generating oxidase of B lymphocytes: Epstein-Barr virus-immortalized B lymphocytes as a tool for the identification of defective components of the oxidase in chronic granulamatous disease

1993 • 26 citations

Regulation of the redox potentials of flavodoxins: Modification of the flavin binding site

1996 • 25 citations

Activation of cytosolic phospholipase A2 in permeabilized human neutrophils

1996 • 25 citations

Inhibition of O2⨪ generating oxidase of neutrophils by iodonium biphenyl in a cell free system: Effect of the redox state of the oxidase complex

1991 • 25 citations

Fluorescent Labeling of the Leukocyte NADPH Oxidase Subunit p47phox: Evidence for Amphiphile-Induced Conformational Changes

1998 • 24 citations

Overexpression of CCAAT Displacement Protein Represses the Promiscuously Active Proximal gp91phox Promoter

1999 • 23 citations

The Ku70 autoantigen interacts with p40phox in B lymphocytes

1999 • 23 citations

Electron Spin Resonance Studies on Neutrophil Cytochrome b558.

1995 • 19 citations

Identification of a Spectrally Stable Proteolytic Fragment of Human Neutrophil Flavocytochrome b Composed of the NH2-terminal Regions of gp91 and p22

2001 • 19 citations

Exploration of the diaphorase activity of neutrophil NADPH oxidase

2002 • 19 citations

Inhibition of the neutrophil NADPH oxidase and associated H+ channel by diethyl pyrocarbonate (DEPC), a histidine-modifying agent: evidence for at least two target sites

2001 • 17 citations

The Rap1A Protein Enhances Protein Kinase C Activity in Vitro

1993 • 17 citations

Aerobic and anaerobic functioning of superoxide-producing cytochrome b-559 reconstituted with phospholipids

1995 • 15 citations

Electron paramagnetic resonance studies on cytochrome b-558 and peroxidases of pig blood granulocytes

1992 • 14 citations

Oxidant-Dependent Phosphorylation of p40phox in B Lymphocytes

2001 • 13 citations

Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67phoxhomolog

2002 • 13 citations

Possible role of RAC-GTPASE-activating protein in the termination of superoxide production in phagocytic cells

1999 • 11 citations

Correction of genetic blood defects by gene transfer

2001 • 11 citations

Structure of the NADPH-oxidase: membrane components.

1993 • 10 citations

X-linked chronic granulomatous disease: from chromosomal position to the in vivo gene product

1987 • 10 citations

PU.l Is Dominant and HAF-1 Supplementary for Activation of the gp91Phox Promoter in Human Monocytic PLB-985 Cells

2002 • 8 citations

Assessment of the Flavoprotein Nature of the Redox Core of Neutrophil NADPH Oxidase

1996 • 6 citations

Inactivation of NADPH oxidase from human neutrophils by affinity labelling with pyridoxal 5′-diphospho-5′-adenosine

1991 • 4 citations

Molecular genetic analysis of phagocyte oxidase cytochrome b558 mutations leading to chronic granulomatous disease.

1993 • 3 citations