Rac1 Disrupts p67phox/p40phox Binding: A Novel Role for Rac in NADPH Oxidase Activation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

NADPH Oxidase Activity Is Independent of p47

1996 • 154 citations

Cytosolic Phox proteins interact with and regulate the assembly of coronin in neutrophils

1997 • 152 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system.

1992 • 150 citations

The Cytosolic Component p47 Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

1996 • 150 citations

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

1996 • 138 citations

Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.

1991 • 124 citations

p40 Down-regulates NADPH Oxidase Activity through Interactions with Its SH3 Domain

1997 • 113 citations

A Novel Cytosolic Component, p40phox, of Respiratory Burst Oxidase Associates with p67phox and Is Absent in Patients with Chronic Granulomatous Disease Who Lack p67phox

1994 • 113 citations

Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.

1995 • 106 citations

The Cytosolic Activating Factors p47phox and p67phox Have Distinct Roles in the Regulation of Electron Flow in NADPH Oxidase

1995 • 104 citations

Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox.

1996 • 96 citations

Isolation of a Complex of Respiratory Burst Oxidase Components from Resting Neutrophil Cytosol

1994 • 96 citations

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

1995 • 93 citations

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

1998 • 84 citations

Purification of the 260 kDa cytosolic complex involved in the Superoxide production of guinea pig neutrophils

1993 • 83 citations

Kinase-dependent Activation of the Leukocyte NADPH Oxidase in a Cell-free System

1997 • 81 citations

Mapping the Domains of Interaction of p40 with Both p47 and p67 of the Neutrophil Oxidase Complex Using the Two-hybrid System

1995 • 81 citations

The PC motif : a novel and evolutionarily conserved sequence involved in interaction between p40 ^phox and p67^phox, SH3 domain‐containing cytosolic factors of the phagocyte NADPH oxidase

1998 • 80 citations

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils

1995 • 80 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation

1995 • 74 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

Topological organization of the cytosolic activating complex of the superoxide-generating NADPH-oxidase. Pinpointing the sites of interaction between p47phox, p67phox and p40phox using the two-hybrid system

1996 • 51 citations

Evidence that Activation of the Respiratory Burst Oxidase in a Cell-Free System from Human Neutrophils is Accomplished in Part Through an Alteration of the Oxidase-Related 67-kDa Cytosolic Protein

1989 • 25 citations

Phagocyte NADPH Oxidase p67-phoxPossesses a Novel Carboxylterminal Binding Site for the GTPases Rac2 and Cdc42

1998 • 19 citations

Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein

1993 • 10 citations