Signaling pathways in phagocytosis

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody

1971 • 1,093 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.

1975 • 595 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

The when and how of Src regulation

1993 • 543 citations

Professional and non-professional phagocytes: an introduction

1995 • 521 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

1996 • 423 citations

Signal transduction in the mammalian cell during bacterial attachment and entry

1993 • 364 citations

Fc receptors: Rubor redux

1994 • 361 citations

Coronin involved in phagocytosis: Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag

1995 • 353 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages.

1995 • 303 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysis

1972 • 258 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

Aggregation of complement receptors on human neutrophils in the absence of ligand.

1987 • 250 citations

Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

1994 • 247 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.

1996 • 237 citations

Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils.

1990 • 229 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1994 • 212 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Ca2+-dependent and Ca2+-independent phagocytosis in human neutrophils

1985 • 211 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Signal transduction of phagocytosis

1995 • 190 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway.

1995 • 181 citations

Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages.

1991 • 175 citations

Tyrosine Phosphorylation and Translocation of the c-Cbl Protein after Activation of Tyrosine Kinase Signaling Pathways

1995 • 171 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

Isolation and characterization of beta-glucan receptors on human mononuclear phagocytes.

1991 • 161 citations

CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway

1998 • 145 citations

Rho-dependent membrane folding causes Shigella entry into epithelial cells.

1996 • 141 citations

Clustered syk tyrosine kinase domains trigger phagocytosis.

1996 • 140 citations

Talin-Null Cells of Dictyostelium Are Strongly Defective in Adhesion to Particle and Substrate Surfaces and Slightly Impaired in Cytokinesis

1997 • 138 citations

Multiple systems for recognition of apoptotic lymphocytes by macrophages.

1997 • 133 citations

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

1995 • 125 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases

1998 • 120 citations

Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.

1992 • 115 citations

Phagosome-lysosome fusion is a calcium-independent event in macrophages.

1996 • 115 citations

Phosphoinositide 3-Kinase and p72 Noncovalently Associate with the Low Affinity Fcγ Receptor on Human Platelets through an Immunoreceptor Tyrosine-based Activation Motif

1996 • 111 citations

Differential localization of Acanthamoeba myosin I isoforms.

1992 • 110 citations

Inhibition of endosome fusion by phospholipase A2 (PLA2) inhibitors points to a role for PLA2 in endocytosis.

1993 • 109 citations

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.

1996 • 108 citations

Activation of phospholipase D is tightly coupled to the phagocytosis of Mycobacterium tuberculosis or opsonized zymosan by human macrophages.

1996 • 108 citations

Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium.

1993 • 88 citations

Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis [published erratum appears in Blood 1994 Nov 1;84(9):3252]

1994 • 88 citations

Tyrosine phosphorylation and Fcγ receptor‐mediated phagocytosis

1997 • 79 citations

Macrophages lacking scavenger receptor A show a decrease in binding and uptake of acetylated low-density lipoprotein and of apoptotic thymocytes, but not of oxidatively damaged red blood cells

1997 • 75 citations

MacMARCKS Mutation Blocks Macrophage Phagocytosis of Zymosan

1995 • 75 citations

Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

1998 • 69 citations

Fusion between large phagocytic vesicles: Targeting of yeast and other particulates to phagolysosomes that shelter the bacterium Coxiella burnetii or the protozoan Leishmania amazonensis in chinese hamster ovary cells

1994 • 69 citations

Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.

1996 • 65 citations

Signal transduction by the SRC family of tyrosine protein kinases in hemopoietic cells.

1991 • 64 citations

Fc receptor-directed phagocytic stimuli induce transient actin assembly at an early stage of phagocytosis in neutrophil leukocytes.

1984 • 61 citations

Protein kinase C activation precedes arachidonic acid release during IgG-mediated phagocytosis.

1995 • 60 citations

Bromophenacyl bromide binding to the actin-bundling protein l-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils.

1994 • 56 citations

In Vivo and In Vitro Specificity of Protein Tyrosine Kinases for Immunoglobulin G Receptor (FcγRII) Phosphorylation

1996 • 56 citations

The Ca2+ Dependence of Human Fcγ Receptor-initiated Phagocytosis

1995 • 55 citations

Phospholipase A2 inhibition results in sequestration of plasma membrane into electronlucent vesicles during IgG-mediated phagocytosis

1997 • 52 citations

Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

1997 • 45 citations

Specific association of phosphatidylinositol 3‐kinase with the protooncogene product Cbl in Fcγ receptor signaling

1996 • 44 citations

The Role of Tyrosine Phosphorylation and Ca2+ Accumulation in Fcγ-Receptor-Mediated Phagocytosis of Human Neutrophils1

1995 • 42 citations

Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src.

1993 • 34 citations

Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function

1994 • 34 citations

Syk kinase, tyrosine-phosphorylated proteins and actin filaments accumulate at forming phagosomes during Fcγ receptor-mediated phagocytosis

1997 • 33 citations

Tyrosine phosphorylation/dephosphorylation controls capping of Fc? receptor II in U937 cells

1999 • 13 citations

PARTICIPATION OF MYOSIN I, SPECTRIN ANALOGUE AND TYROSINE-PHOSPHORYLATED PROTEINS AT EARLY STAGES OF PHAGOCYTOSIS IN ACANTHAMOEBA CASTELLANII

1998 • 5 citations

Deleted Work

1955 • 0 citations