NADPH oxidase of neutrophils

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

1980 • 2,158 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Molecular biology of the cell

1983 • 1,007 citations

Intracellular phospholipases A

1980 • 989 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood *

1967 • 932 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

Human Leukemic Models of Myelomonocytic Development: A Review of the HL-60 and U937 Cell Lines

1985 • 649 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

1986 • 551 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

ORIGIN OF GRANULES IN POLYMORPHONUCLEAR LEUKOCYTES

1966 • 476 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

1993 • 424 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

1987 • 405 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

1982 • 316 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b−245

1987 • 292 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

GTP-binding proteins in intracellular transport

1992 • 277 citations

Gaining access to the cytosol: the technique and some applications of electropermeabilization

1986 • 275 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system.

1987 • 266 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Identification of a superoxide-generating NADPH oxidase system in human fibroblasts

1991 • 233 citations

Functional activity of enucleated human polymorphonuclear leukocytes.

1983 • 230 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Chronic granulomatous disease

1994 • 223 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Characterization of a new human diploid myeloid leukemia cell line (PLB- 985) with granulocytic and monocytic differentiating capacity

1987 • 219 citations

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

1985 • 216 citations

The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages

1987 • 211 citations

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.

1981 • 208 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Use of lipophilic probes of membrane potential to assess human neutrophil activation. Abnormality in chronic granulomatous disease.

1980 • 203 citations

Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

1980 • 198 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Biochemistry and Physiology of the Neutrophil

1994 • 189 citations

Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells.

1987 • 188 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel

1988 • 178 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils

1993 • 170 citations

Intracellular phospholipases A

1980 • 165 citations

Small GTP-binding proteins and their role in transport

1991 • 164 citations

An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

1994 • 160 citations

Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.

1988 • 153 citations

A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.

1989 • 148 citations

Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils

1992 • 145 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines.

1989 • 140 citations

The Genetic Basis of Chronic Granulomatous Disease

1994 • 139 citations

Hydrogen ion currents in rat alveolar epithelial cells

1991 • 137 citations

Involvement of phenyl radicals in iodonium inhibition of flavoenzymes.

1994 • 137 citations

Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression.

1990 • 137 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chediak-Higashi syndrome.

1984 • 132 citations

Voltage-activated hydrogen ion currents

1994 • 132 citations

Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge.

1988 • 132 citations

A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages.

1993 • 132 citations

Activation of the superoxide radical generating oxidase in plasma membrane from bovine polymorphonuclear neutrophils by arachidonic acid, a cytosolic factor of protein nature, and nonhydrolyzable analogs of GTP

1988 • 127 citations

Cytoplasmic pH regulation in phorbol ester-activated human neutrophils

1986 • 126 citations

Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH

1985 • 126 citations

Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

1993 • 125 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

1993 • 124 citations

Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells

1989 • 117 citations

Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium

1977 • 116 citations

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.

1993 • 115 citations

Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase

1989 • 112 citations

Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils

1986 • 111 citations

Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils.

1987 • 111 citations

Topology of cytochrome b558 in neutrophil membrane analyzed by anti-peptide antibodies and proteolysis.

1992 • 110 citations

Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.

1994 • 108 citations

Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium

1990 • 106 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

Role of p67-phox SH3 domains in assembly of the NADPH oxidase system.

1994 • 106 citations

Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.

1995 • 106 citations

Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications

1993 • 105 citations

Cytochrome b-245 from human neutrophils is a glycoprotein

1985 • 103 citations

Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins

1993 • 101 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig.

1988 • 100 citations

Generation of Superoxide by purified and relipidated cytochrome b₅₅₉ in the absence of cytosolic activators

1993 • 99 citations

Fatty‐acid‐induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides

1987 • 97 citations

Human Neutrophil Heterogeneity Identified Using Flow Microfluorometry to Monitor Membrane Potential

1981 • 96 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

Simultaneous measurement of stimulus-induced changes in cytoplasmic Ca2+ and in membrane potential of human neutrophils.

1986 • 93 citations

The functional expression of p47‐phox and p67‐phox may contribute to the generation of superoxide by an NADPH oxidase‐like system in human fibroblasts

1994 • 93 citations

Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2)

1993 • 93 citations

Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease.

1988 • 93 citations

The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.

1990 • 89 citations

Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.

1992 • 89 citations

Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line.

1984 • 87 citations

Resonance Raman and electron paramagnetic resonance structural investigations of neutrophil cytochrome b558

1991 • 84 citations

Purification of the 260 kDa cytosolic complex involved in the Superoxide production of guinea pig neutrophils

1993 • 83 citations

The immediate activator of the NADPH oxidase is arachidonate not phosphorylation

1993 • 82 citations

The two redox potentials for oxygen reduction to superoxide

1987 • 82 citations

Mapping the Domains of Interaction of p40 with Both p47 and p67 of the Neutrophil Oxidase Complex Using the Two-hybrid System

1995 • 81 citations

The respiratory burst oxidase of neutrophils. Separation of an FAD enzyme and its characterization.

1987 • 80 citations

Complementation in monocyte hybrids revealing genetic heterogeneity in chronic granulomatous disease

1984 • 80 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 78 citations

Production of recombinant cytochrome b558 allows reconstitution of the phagocyte NADPH oxidase solely from recombinant proteins

1993 • 76 citations

Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages.

1994 • 75 citations

Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component.

1987 • 73 citations

The respiratory burst of bovine neutrophilis

1985 • 73 citations

Phorbol 12-myristate 13-acetate activates an electrogenic H+-conducting pathway in the membrane of neutrophils

1992 • 72 citations

The NADPH-oxidase-associated H+ channel is opened by arachidonate

1992 • 69 citations

SH3-dependent assembly of the phagocyte NADPH oxidase.

1994 • 68 citations

Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL-60) cell line

1982 • 67 citations

p22-phox-deficient chronic granulomatous disease: reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox

1994 • 67 citations

Superoxide production by cytochrome b₅₅₉

1994 • 66 citations

Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils

1990 • 66 citations

Phorbol ester-induced changes of cytoplasmic pH in neutrophils: role of exocytosis in Na+-H+ exchange

1985 • 64 citations

1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms

1989 • 58 citations

Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes

1993 • 58 citations

The inhibitory effects of some iodonium compounds on the superoxide generating system of neutrophils and their failure to inhibit diaphorase activity

1987 • 58 citations

Activation of O₂⁻‐generating oxidase in an heterologous cell‐free system derived from Epstein‐Barr‐virus‐transformed human B lymphocytes and bovine neutrophils

1991 • 56 citations

Differentiation of human promyelocytic HL 60 cells by retinoic acid is accompanied by an increase in the intracellular pH. The role of the Na+/H+ exchange system.

1987 • 55 citations

Phosphorylation of the subunits of cytochrome b-245 upon triggering of the respiratory burst of human neutrophils and macrophages

1988 • 53 citations

Purification and some properties of the small subunit of cytochrome b558 from human neutrophils

1989 • 53 citations

NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes.

1980 • 51 citations

Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA.

1993 • 50 citations

Examination of the oxidase function of the b-type cytochrome in human polymorphonuclear leucocytes

1984 • 49 citations

Identification of the haem-binding subunit of cytochrome b−245

1989 • 49 citations

Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils

1990 • 47 citations

Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.

1994 • 47 citations

Critical assessment of the presence of an NADPH binding site on neutrophil cytochrome b558 by photoaffinity and immunochemical labeling

1993 • 47 citations

Growth and differentiation of human myeloid leukemia cell line HL60

1990 • 47 citations

Photoaffinity Labeling and Photoinactivation of the O2--Generating Oxidase of Neutrophils by an Azido Derivative of FAD

1995 • 42 citations

Reconstitution of superoxide-forming NADPH oxidase activity with cytochrome b558 purified from porcine neutrophils. Requirement of a membrane-bound flavin enzyme for reconstitution of activity.

1992 • 42 citations

Morphologic and cytochemical studies of rabbit heterophilic leukocytes. Evidence for tertiary granules.

1973 • 41 citations

Dissociation of human neutrophil membrane depolarization, respiratory burst stimulation and phospholipid metabolism by quinacrine

1983 • 41 citations

Increase in the expression of a family of small guanosine triphosphate-binding proteins, rab proteins, during induced phagocyte differentiation.

1991 • 41 citations

The p67-phox cytosolic peptide of the respiratory burst oxidase from human neutrophils. Functional aspects.

1990 • 40 citations

Rapid incorporation of the human neutrophil plasma membrane cytochrome b into phagocytic vacuoles

1980 • 40 citations

Intracellular pH Changes During Neutrophil Activation: Na+ /H+ Antiport

1987 • 40 citations

Paradoxical Effects of Retinal in Neutrophil Stimulation

1989 • 39 citations

Asparagine-linked glycosylation of cytochrome b558 large subunit varies in different human phagocytic cells.

1989 • 37 citations

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

1988 • 36 citations

Induction of Essential Components of the Superoxide Generating System in Human Monoblastic Leukemia U937 Cells1

1994 • 35 citations

Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.

1994 • 35 citations

Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils

1989 • 34 citations

Parameters of activation of the membrane-bound O2• generating oxidase from bovine neutrophils in a cell-free system

1989 • 33 citations

Transmembrane potential changes during phagocytosis in rat alveolar macrophages

1981 • 33 citations

Characterization of neutrophil b‐type cytochrome in situ by electron paramagnetic resonance spectroscopy

1991 • 31 citations

Chemotactic factor-induced membrane potential changes in rabbit neutrophils monitored by the fluorescent dye 3,3′-dipropylthiadicarbocyanine iodide

1980 • 29 citations

Purification and characterization of an oxidase activating factor of 63-kilodaltons from bovine neutrophils

1991 • 29 citations

A 63-kilodalton cytosolic polypeptide involved in superoxide generation in porcine neutrophils. Purification and characterization.

1990 • 28 citations

Activation of electropermeabilized neutrophils by adenosine 5′-[γ-thio]triphosphate (ATP[S]). Role of phosphatases in stimulus-response coupling

1989 • 27 citations

Activation of NADPH oxidase in human neutrophils permeabilized with Staphylococcus aureus alpha-toxin. A lower Km when the enzyme is activated in situ.

1992 • 26 citations

Two cytosolic components of the neutrophil NADPH oxidase, P47-PHOX and P67-PHOX, are not flavoproteins

1990 • 26 citations

Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells

1994 • 26 citations

Biochemistry and physiology of the neutrophil

1995 • 26 citations

Inhibition of O2⨪ generating oxidase of neutrophils by iodonium biphenyl in a cell free system: Effect of the redox state of the oxidase complex

1991 • 25 citations

Superoxide generation by EBV-transformed B lymphocytes. Activation by IL-1 beta, TNF-alpha and receptor independent stimuli.

1990 • 24 citations

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

1988 • 20 citations

Regulation of phagocyte function by low molecular weight GTP-binding proteins

1993 • 19 citations

Phagocyte NADPH-oxidase. Studies with flavin analogues as active site probes in triton X-100-solubilized preparations.

1988 • 18 citations

Cytosolic components involved in porcine neutrophil oxidase activation. Purification of a 47-kilodalton protein and reconstitution of the activation system.

1992 • 13 citations

Purification and properties of a functional 47-kilodalton cytosolic factor required for NADPH-oxidase activation in bovine neutrophils

1992 • 12 citations

Lymphocytes possess an electrogenic H+-transporting pathway in their plasma membrane

1994 • 12 citations