Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

1976 • 2,658 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

Essential Role for Cholesterol in Entry of Mycobacteria into Macrophages

2000 • 610 citations

Gap43, Marcks, and Cap23 Modulate Pi(4,5)p2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism

2000 • 591 citations

Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

2000 • 537 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension

1999 • 414 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

1998 • 331 citations

Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides

2000 • 300 citations

Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton's Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells

1999 • 291 citations

A contractile activity that closes phagosomes in macrophages

1999 • 279 citations

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

2000 • 246 citations

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1994 • 212 citations

Nonopsonic Phagocytosis of Mycobacterium kansasii by Human Neutrophils Depends on Cholesterol and Is Mediated by CR3 Associated with Glycosylphosphatidylinositol-Anchored Proteins

2000 • 203 citations

Compartmentalized IgE Receptor–mediated Signal Transduction in Living Cells

1997 • 189 citations

Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages

2000 • 180 citations

A Regulatory Role for Src Homology 2 Domain–Containing Inositol 5′-Phosphatase (Ship) in Phagocytosis Mediated by Fcγ Receptors and Complement Receptor 3 (αMβ2; Cd11b/Cd18)

2000 • 157 citations

Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.

1992 • 145 citations

Interaction of the EEA1 FYVE Finger with Phosphatidylinositol 3-Phosphate and Early Endosomes

2000 • 145 citations

A versatile microporation technique for the transfection of cultured CNS neurons

1999 • 139 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.

1992 • 108 citations

Differential Involvement of Src Family Kinases in Fcγ Receptor-Mediated Phagocytosis

2000 • 100 citations

Dynamics of rab5 activation in endocytosis and phagocytosis

2000 • 93 citations

Asymmetric lateral mobility of phospholipids in the human erythrocyte membrane.

1986 • 81 citations

Annexin IV Reduces the Rate of Lateral Lipid Diffusion and Changes the Fluid Phase Structure of the Lipid Bilayer When It Binds to Negatively Charged Membranes in the Presence of Calcium

1994 • 67 citations

Phospholipid transmembrane domains and lateral diffusion in fibroblasts.

1993 • 49 citations

Chimeric Receptors Composed of Phosphoinositide 3-Kinase Domains and Fcγ Receptor Ligand-binding Domains Mediate Phagocytosis in COS Fibroblasts

1998 • 42 citations

Insufficient Phosphorylation Prevents FcγRIIB from Recruiting the SH2 Domain-containing Protein-tyrosine Phosphatase SHP-1

2001 • 42 citations

Diversity in phagocytic signalling

2001 • 39 citations

Deleted Work

1955 • 0 citations