Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67phoxhomolog

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2000 • 1,104 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Redox‐dependent signal transduction

2000 • 558 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

1997 • 463 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Novel homologs of gp91phox

2000 • 356 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Role of NADPH Oxidase in the Vascular Hypertrophic and Oxidative Stress Response to Angiotensin II in Mice

2001 • 336 citations

Calcineurin: From structure to function

2001 • 298 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p47 as Determined by Two-dimensional Phosphopeptide Mapping

1996 • 241 citations

Cabin 1, A Negative Regulator for Calcineurin Signaling in T Lymphocytes

1998 • 235 citations

Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase

1999 • 230 citations

Angiotensin II Induces p67 ^phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts

1998 • 228 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.

2000 • 203 citations

The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

1995 • 184 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Impaired Superoxide Production Due to a Deficiency in Phagocyte NADPH Oxidase Fails to Inhibit Atherosclerosis in Mice

2000 • 175 citations

Activation of the Neutrophil Respiratory Burst Oxidase

1999 • 174 citations

Topological Mapping of Neutrophil Cytochrome b Epitopes with Phage-display Libraries

1995 • 162 citations

Vascular Effects Following Homozygous Disruption of p47 ^phox

2000 • 158 citations

Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries.

1995 • 148 citations

A central role for the endothelial NADPH oxidase in atherosclerosis

2000 • 147 citations

Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67 ^PHOX and cytochrome b ₅₅₈ II

2002 • 140 citations

Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils

1994 • 136 citations

Assembly of the Human Neutrophil NADPH Oxidase Involves Binding of p67 and Flavocytochrome to a Common Functional Domain in p47

1996 • 124 citations

The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct

1993 • 119 citations

Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.

1996 • 116 citations

p40 Down-regulates NADPH Oxidase Activity through Interactions with Its SH3 Domain

1997 • 113 citations

The molecular basis of chronic granulomatous disease

1998 • 112 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Molecular cloning of the fMet-Leu-Phe receptor from neutrophils

1990 • 101 citations

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

1997 • 100 citations

Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67 ^PHOX and cytochrome b ₅₅₈

2001 • 95 citations

Oxidase activation in individual neutrophils is dependent on the onset and magnitude of the Ca2+ signal

1990 • 93 citations

Follow up of patients with chronic granulomatous disease diagnosed since 1990

2000 • 92 citations

The NADPH‐Dependent Oxidase of Phagocytes

1999 • 89 citations

Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox

1996 • 89 citations

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

1998 • 84 citations

The PC motif : a novel and evolutionarily conserved sequence involved in interaction between p40 ^phox and p67^phox, SH3 domain‐containing cytosolic factors of the phagocyte NADPH oxidase

1998 • 80 citations

Watanabe rabbits with heritable hypercholesterolaemia: a model of atherosclerosis.

1998 • 76 citations

p40phox participates in the activation of NADPH oxidase by increasing the affinity of p47phox for flavocytochrome b558

2000 • 76 citations

The calcium signal and neutrophil activation

1990 • 75 citations

Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control

2001 • 73 citations

Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils.

1994 • 70 citations

Separation of neutrophils from blood in human and laboratory animals and comparison of the chemotaxis

1995 • 69 citations

Cloning and sequencing of the bovine flavocytochrome b subunit proteins, gp91-phox and p22-phox: comparison with other known flavocytochrome b sequences

1998 • 52 citations

The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.

1996 • 49 citations

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233

1999 • 44 citations

p40phox participates in the activation of NADPH oxidase by increasing the affinity of p47phox for flavocytochrome b558

2000 • 42 citations

Sequential generation of cytokines during the initiative phase of inflammation, with reference to neutrophils

1998 • 42 citations

The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications.

1993 • 41 citations

Rabbit Models of Pneumonia, Peritoneal Sepsis, and Lung Injury

2003 • 12 citations

Cloning and expression of bovine p47-phoxand p67-phox: comparison with the human and murine homologs

2000 • 12 citations

Identification of neutrophil NADPH oxidase proteins gp91-phox, p22-phox, p67-phox, and p47-phox in mammalian species.

1996 • 8 citations

Identification of neutrophil NADPH oxidase proteins gp91-phox, p22-phox, p67-phox, and p47-phox in mammalian species

1996 • 7 citations