Chronic granulomatous disease

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood *

1967 • 932 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease

1991 • 785 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Atomic Structure of Ferredoxin-NADP ⁺ Reductase: Prototype for a Structurally Novel Flavoenzyme Family

1991 • 532 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

The signal for capacitative calcium entry

1993 • 423 citations

Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation

1991 • 416 citations

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

1987 • 405 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation

1991 • 344 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

1985 • 334 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

A Fatal Granulomatous Disease of Childhood

1959 • 297 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b−245

1987 • 292 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

Incidence, severity, and prevention of infections in chronic granulomatous disease

1989 • 272 citations

Protein kinase C and the activation of the human neutrophil NADPH- oxidase

1987 • 268 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes.

1975 • 265 citations

Partial Correction of the Phagocyte Defect in Patients with X-Linked Chronic Granulomatous Disease by Subcutaneous Interferon Gamma

1988 • 264 citations

Bacterial cytochrome oxidases a structurally and functionally diverse group of electron-transfer protein

1983 • 263 citations

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

1984 • 262 citations

Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

1989 • 258 citations

Trimethoprim-Sulfamethoxazole Prophylaxis in the Management of Chronic Granulomatous Disease

1990 • 257 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

A SYNDROME OF RECURRENT INFECTION AND INFILTRATION OF VISCERA BY PIGMENTED LIPID HISTIOCYTES

1957 • 251 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

The enzymic reduction and kinetics of oxidation of cytochrome b.245 of neutrophils

1982 • 247 citations

Ras-related GTPases and the cytoskeleton.

1992 • 232 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

AFFINITY LABELING OF PURINE NUCLEOTIDE SITES IN PROTEINS

1983 • 216 citations

Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.

1989 • 213 citations

Deficiency of Reduced Nicotinamide-Adenine Dinucleotide Oxidase in Chronic Granulomatous Disease

1968 • 201 citations

Chronic Granulomatous Disease: The Solving of a Clinical Riddle at the Molecular Level

1993 • 185 citations

Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst ¹

1993 • 184 citations

Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils. Defects in the phosphorylation of a group of closely related 48-kDa proteins in two forms of chronic granulomatous disease.

1988 • 181 citations

Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor

1982 • 177 citations

Enzymatic Basis of the Respiratory Stimulation During Phagocytosis

1964 • 176 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.

1987 • 172 citations

The NBT slide test: A simple screening method for detecting chronic granulomatous disease and female carriers

1973 • 171 citations

Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease

1989 • 163 citations

Exposure of human neutrophils to chemotactic factors potentiates activation of the respiratory burst enzyme.

1983 • 157 citations

Phagolysosomal pH of human neutrophils

1984 • 154 citations

Prenatal Diagnosis of Chronic Granulomatous Disease

1979 • 153 citations

The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system.

1992 • 150 citations

A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.

1989 • 148 citations

Respiratory burst oxidase and three of four oxidase-related polypeptides are associated with the cytoskeleton of human neutrophils.

1991 • 148 citations

Chemiluminescence detection of H2O2 produced by human neutrophils during the respiratory burst

1987 • 148 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18

1993 • 143 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines.

1989 • 140 citations

Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease

1987 • 137 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chediak-Higashi syndrome.

1984 • 132 citations

Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase

1990 • 129 citations

The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase.

1993 • 128 citations

Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease.

1988 • 127 citations

Chronic Granulomatous Disease Presenting in a 69-Year-Old Man

1991 • 127 citations

Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH

1985 • 126 citations

Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

1993 • 125 citations

A structural model for the nucleotide binding domains of the flavocytochrome b_–245 β‐chain

1993 • 124 citations

Inhibition of Rap1A Binding to Cytochrome b ₅₅₈ of NADPH Oxidase by Phosphorylation of Rap1A

1991 • 120 citations

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

1992 • 120 citations

Point mutations in the beta-subunit of cytochrome b558 leading to X- linked chronic granulomatous disease

1991 • 120 citations

Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.

1991 • 119 citations

Stimulation and priming of human neutrophils by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: Qualitative and quantitative differences

1990 • 118 citations

Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein

1992 • 118 citations

Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease

1980 • 117 citations

Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells

1989 • 117 citations

NITROBLUE-TETRAZOLIUM TESTS

1974 • 116 citations

A Novel Cytosolic Component, p40phox, of Respiratory Burst Oxidase Associates with p67phox and Is Absent in Patients with Chronic Granulomatous Disease Who Lack p67phox

1994 • 113 citations

The association of FAD with the cytochrome b–245 of human neutrophils

1982 • 112 citations

Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils

1986 • 111 citations

Kinetics of activation of the respiratory burst oxidase in a fully soluble system from human neutrophils.

1988 • 111 citations

Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils.

1987 • 111 citations

Topology of cytochrome b558 in neutrophil membrane analyzed by anti-peptide antibodies and proteolysis.

1992 • 110 citations

Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

1982 • 109 citations

Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.

1990 • 108 citations

Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin. Implications for regulation of the respiratory burst.

1987 • 108 citations

The neutrophil

1989 • 104 citations

Cytochrome b-245 from human neutrophils is a glycoprotein

1985 • 103 citations

Chronic granulomatous disease due to a defect in the cytosolic factor required for nicotinamide adenine dinucleotide phosphate oxidase activation.

1988 • 103 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Purification and partial characterization of the b-type cytochrome from human polymorphonuclear leukocytes.

1985 • 97 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

Prognosis of chronic granulomatous disease.

1990 • 93 citations

Characterization of the 47-Kilodalton Autosomal Chronic Granulomatous Disease Protein: Tissue-Specific Expression and Transcriptional Control by Retinoic Acid

1990 • 93 citations

Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease.

1988 • 93 citations

1-O-Hexadecyl-2-O-methylglycerol, a Novel Inhibitor of Protein Kinase C, Inhibits the Respiratory Burst in Human Neutrophils

1989 • 89 citations

The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.

1990 • 89 citations

Electron spin resonance studies on a flavoprotein in neutrophil plasma membranes. Redox potentials of the flavin and its participation in NADPH oxidase.

1986 • 89 citations

Purification of cytochrome b-245 from human neutrophils

1984 • 88 citations

A phosphoprotein of Mr 47,000, defective in autosomal chronic granulomatous disease, copurifies with one of two soluble components required for NADPH:O2 oxidoreductase activity in human neutrophils.

1989 • 87 citations

Resonance Raman and electron paramagnetic resonance structural investigations of neutrophil cytochrome b558

1991 • 84 citations

Purification of the 260 kDa cytosolic complex involved in the Superoxide production of guinea pig neutrophils

1993 • 83 citations

The two redox potentials for oxygen reduction to superoxide

1987 • 82 citations

CHARACTERISATION OF THE ENZYME DEFECT IN CHRONIC GRANULOMATOUS DISEASE

1976 • 81 citations

Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases

1980 • 79 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 78 citations

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.

1991 • 78 citations

Phosphorylation of the oxidase-related 48K phosphoprotein family in the unusual autosomal cytochrome-negative and X-linked cytochrome-positive types of chronic granulomatous disease

1988 • 76 citations

Production of recombinant cytochrome b558 allows reconstitution of the phagocyte NADPH oxidase solely from recombinant proteins

1993 • 76 citations

Prolonged recombinant interferon-gamma therapy in chronic granulomatous disease: evidence against enhanced neutrophil oxidase activity

1992 • 75 citations

Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.

1984 • 75 citations

Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein

1991 • 73 citations

Production of superoxide and hydrogen peroxide by an NADH-oxidase in guinea pig polymorphonuclear leukocytes. Modulation by nucleotides and divalent cations.

1979 • 73 citations

Affinity Labeling of the Cytosolic and Membrane Components of the Respiratory Burst Oxidase by the 2′,3′-Dialdehyde Derivative of NADPH

1989 • 72 citations

In vitro molecular reconstitution of the respiratory burst in B lymphoblasts from p47-phox-deficient chronic granulomatous disease.

1993 • 70 citations

Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL-60) cell line

1982 • 67 citations

Deficient flavoprotein component of the NADPH-dependent O2-.-generating oxidase in the neutrophils from three male patients with chronic granulomatous disease.

1984 • 67 citations

Reevaluation of cytochrome b and flavin adenine dinucleotide in neutrophils from patients with chronic granulomatous disease and description of a family with probable autosomal recessive inheritance of cytochrome b deficiency

1986 • 66 citations

A study of 25 patients with chronic granulomatous disease: A new classification by correlating respiratory burst, cytochrome b, and flavoprotein

1986 • 63 citations

The cytochrome b and flavin content and properties of the O2−-forming NADPH oxidase solubilized from activated neutrophils

1983 • 63 citations

Clinical differences in chronic granulomatous disease in patients with cytochrome b-negative or cytochrome b-positive neutrophils

1985 • 62 citations

Interferon Gamma-1b

1992 • 62 citations

NADPH binding component of neutrophil superoxide-generating oxidase.

1986 • 61 citations

Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor

1992 • 61 citations

Marrow transplantation in chronic granulomatous disease: An update, with 6-year follow-up

1988 • 60 citations

The activity of one soluble component of the cell-free NADPH:O2 oxidoreductase of human neutrophils depends on guanosine 5'-O-(3-thio)triphosphate.

1990 • 60 citations

Chronic granulomatous disease with partial deficiency of cytochrome b558 and incomplete respiratory burst: variants of the X-linked, cytochrome b558-negative form of the disease

1992 • 60 citations

The management of chronic granulomatous disease

1993 • 59 citations

Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox).

1992 • 59 citations

Studies on neutrophil b-type cytochrome in situ by low temperature absorption spectroscopy.

1985 • 59 citations

Splice site mutations are a common cause of X-linked chronic granulomatous disease

1992 • 59 citations

Characterization of the NADPH-dependent superoxide production activated by sodium dodecyl sulfate in a cell-free system of pig neutrophils

1987 • 58 citations

The inhibitory effects of some iodonium compounds on the superoxide generating system of neutrophils and their failure to inhibit diaphorase activity

1987 • 58 citations

Restoration of superoxide generation to a chronic granulomatous disease- derived B-cell line by retrovirus mediated gene transfer

1992 • 57 citations

Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.

1988 • 57 citations

A New Cytochrome in Neutrophilic Granules of Rabbit Leucocyte

1966 • 55 citations

Purification and some properties of the small subunit of cytochrome b558 from human neutrophils

1989 • 53 citations

Bone Marrow Transplantation in Practice

1992 • 52 citations

Changes in the subcellular distribution of the cytochrome b-245 on stimulation of human neutrophils

1984 • 51 citations

Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes.

1991 • 51 citations

Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid.

1990 • 50 citations

A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation

1991 • 50 citations

X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox

1993 • 50 citations

Activation of the superoxide-forming NADPH oxidase of macrophages requires two cytosolic components--one of them is also present in certain nonphagocytic cells.

1989 • 49 citations

Identification of the haem-binding subunit of cytochrome b−245

1989 • 49 citations

Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers

1994 • 49 citations

Critical assessment of the presence of an NADPH binding site on neutrophil cytochrome b558 by photoaffinity and immunochemical labeling

1993 • 47 citations

Identification of the NADPH-binding subunit of the respiratory burst oxidase.

1991 • 47 citations

Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils

1990 • 47 citations

Isolation from neutrophil membranes of a complex containing active NADPH oxidase and cytochrome b-245

1984 • 44 citations

Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Relationship with the activation of the NADPH oxidase by different stimuli

1992 • 43 citations

Evidence for the involvement of distinct signal transduction pathways in the regulation of constitutive and interferon gamma-dependent gene expression of NADPH oxidase components (gp91-phox, p47-phox, and p22- phox) and high-affinity receptor for IgG (Fc gamma R-I) in human polymorphonuclear leukocytes

1992 • 42 citations

Identification of the defective NADPH‐oxidase component in Chronic Granulomatous Disease: a study of 57 European families

1992 • 42 citations

Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils

1991 • 39 citations

Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease

1993 • 38 citations

Phorbol myristate acetate stimulated NBT test: a simple method suitable for antenatal diagnosis of chronic granulomatous disease.

1983 • 38 citations

Detection of carriers of the autosomal form of chronic granulomatous disease

1988 • 38 citations

Production of superoxide by neutrophils: a reappraisal

1979 • 37 citations

Superoxide-producing cytochrome b. Enzymatic and electron paramagnetic resonance properties of cytochrome b558 purified from neutrophils.

1993 • 36 citations

The 47-kDa protein involved in the NADPH:O2 oxidoreductase activity of human neutrophils is phosphorylated by cyclic AMP-dependent protein kinase without induction of a respiratory burst

1988 • 36 citations

Chronic granulomatous disease 100% corrected by displacement bone marrow transplantation from a volunteer unrelated donor

1992 • 36 citations

Activation of superoxide radical anion generating oxidase of bovine neutrophils in a cell-free system. Interaction of a cytosolic factor with the plasma membrane and control by G nucleotides

1989 • 36 citations

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

1988 • 36 citations

Synthesis and properties of 2-azido-NAD+. A study of interaction with glutamate dehydrogenase.

1990 • 36 citations

Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels

1993 • 32 citations

Superoxide production by normal and chronic granulomatous disease (CGD) patient-derived EBV-transformed B cell lines measured by chemiluminescence-based assays

1992 • 32 citations

Characterization of neutrophil b‐type cytochrome in situ by electron paramagnetic resonance spectroscopy

1991 • 31 citations

Cytosolic factors in bovine neutrophil oxidase activation. Partial purification and demonstration of translocation to a membrane fraction

1990 • 31 citations

Purification and characterization of an oxidase activating factor of 63-kilodaltons from bovine neutrophils

1991 • 29 citations

The development of cytochrome b-245 in maturing human macrophages

1986 • 29 citations

EPR signals of cytochrome b558 purified from porcine neutrophils.

1992 • 28 citations

A 63-kilodalton cytosolic polypeptide involved in superoxide generation in porcine neutrophils. Purification and characterization.

1990 • 28 citations

Defining a new GAP family

1992 • 28 citations

Properties of NADH-cytochrome-b5 reductase from human neutrophils

1983 • 27 citations

Two cytosolic components of the neutrophil NADPH oxidase, P47-PHOX and P67-PHOX, are not flavoproteins

1990 • 26 citations

Nsi I RFLP at the X-linked chronic granulomatous disease locus (CYBB)

1989 • 25 citations

Nucleotide binding properties of cytosolic components required for expression of activity of the superoxide generating NADPH oxidase

1990 • 24 citations

Prenatal diagnosis in a family with X‐linked chronic granulomatous disease with the use of the polymerase chain reaction

1992 • 23 citations

A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease

1993 • 23 citations

Studies on the Superoxide Releasing Site in Plasma Membranes of Neutrophils with ESR Spin-Labels

1990 • 22 citations

RFLP and deletion analysis for X-linked chronic granulomatous disease using the cDNA probe: potential for improved prenatal diagnosis and carrier determination

1990 • 20 citations

Purification and Characterization of NADPH-Cytochrome c Reductase from Porcine Polymorphonuclear Leukocytes1

1987 • 20 citations

Chronic granulomatous disease of childhood

1993 • 20 citations

RFLP and deletion analysis for X-linked chronic granulomatous disease using the cDNA probe: potential for improved prenatal diagnosis and carrier determination

1990 • 19 citations

Decreased CD4+CD29+ (Memory T) Cells in Patients with Chronic Granulomatous Disease

1993 • 19 citations

Chronic Granulomatous Disease: Diagnosis and Classification at the Molecular Level

1992 • 19 citations

[17] Respiratory burst during phagocytosis: An overview

1986 • 16 citations

The reduction of cytochrome b558 and the activity of the respiratory burst oxidase from human neutrophils.

1992 • 15 citations

Improvement of superoxide production in monocytes from patients with chronic granulomatous disease by recombinant cytokines

1993 • 15 citations

Itraconazole in Neutropenic Patients

1992 • 15 citations

A second Nsil RFLP at the CYBB locus

1990 • 13 citations

Altered antigen-presentation in the induction of the in-vitro antigen-specific T helper cell function in patients with chronic granulomatous disease.

1986 • 13 citations

Molecular characteristics of cytochrome b558 isolated from human granulocytes, monocytes and HL60 and U937 cells differentiated into monocyte/macrophages

1991 • 10 citations

Granulocyte-macrophage colony stimulating factor does not improve neutrophil oxidative metabolism in a patient with variant X-linked chronic granulomatous disease

1991 • 9 citations

Chronic granulomatous disease: mutations in cytochrome b558.

1993 • 9 citations

ESR signals from stimulated and resting porcine blood neutrophils

1987 • 9 citations

Chronic Granulomatous Disease in Japan: A Summary of the Clinical Features of 84 Registered Patients

1985 • 5 citations